Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Foram encontrados 170 produtos de "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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Infigratinib-Boc
CAS:<p>Infigratinib-Boc, a derivative of the ATP-competitive pan-FGFR inhibitor Infigratinib, incorporates a Boc (t-Butyloxy carbonyl) group [1].</p>Fórmula:C29H35Cl2N7O5Cor e Forma:SolidPeso molecular:632.54FGFR4-IN-8
CAS:<p>FGFR4-IN-8 is a selective, ATP-competitive FGFR4 inhibitor with IC50s as low as 0.25 nM, halting growth of Hep3B cells at 29 nM and showing in vivo efficacy.</p>Fórmula:C32H34Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:654.56FGFR-IN-11
CAS:<p>FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (</p>Fórmula:C28H29ClN4O4Pureza:98%Cor e Forma:SolidPeso molecular:521.01Resigratinib
CAS:<p>Resigratinib (KIN-3248) is an oral, irreversible pan-FGFR family protein inhibitor, covalently binds to and inhibits all four FGFR isoforms(FGFR1/2/3/4).</p>Fórmula:C26H27F2N7O3Pureza:98.58%Cor e Forma:SolidPeso molecular:523.53FGFR3-IN-6
CAS:<p>FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Fórmula:C25H23FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:486.5FGFR3-IN-7
CAS:<p>FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].</p>Fórmula:C25H24FN9OPureza:98%Cor e Forma:SolidPeso molecular:485.52FGFR4-IN-16
CAS:<p>FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].</p>Fórmula:C35H30Cl2N6O5Pureza:98%Cor e Forma:SolidPeso molecular:685.56Irpagratinib
CAS:<p>Irpagratinib (ABSK011) is an FGFR4 antagonist with anticancer activity, inhibiting FGFR4 autophosphorylation and blocking downstream signaling pathways.</p>Fórmula:C28H32F2N6O5Pureza:99.08% - 99.38%Cor e Forma:SolidPeso molecular:570.59FIIN-1
CAS:<p>FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3,</p>Fórmula:C32H39Cl2N7O4Pureza:98.75%Cor e Forma:SolidPeso molecular:656.6FGFR3-IN-4
CAS:<p>FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM.</p>Fórmula:C26H24ClN7OCor e Forma:SolidPeso molecular:485.97FGFR4-IN-9
<p>FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.</p>Fórmula:C24H22ClF3N4O4Cor e Forma:SolidPeso molecular:522.9FGFR-IN-5
CAS:<p>FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.</p>Fórmula:C25H22N6O3Cor e Forma:SolidPeso molecular:454.48FGFR-IN-6
CAS:<p>FGFR-IN-6 (Compound 5) is an FGFR inhibitor.</p>Fórmula:C23H22N6O3Cor e Forma:SolidPeso molecular:430.46FGFR4-IN-6
<p>FGFR4-IN-6: covalent, reversible FGFR4 blocker, 5.4 nM IC50, good oral bioavailability, reduces Hep3B2.1-7 tumors in mice, low toxicity.</p>Fórmula:C31H33N7O4Cor e Forma:SolidPeso molecular:567.64E7090 succinate
CAS:<p>E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.</p>Fórmula:C76H92N10O24Cor e Forma:SolidPeso molecular:1529.60FGFR1 inhibitor-6
<p>FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.</p>Fórmula:C27H19N5O4S2Cor e Forma:SolidPeso molecular:541.6CEP-11981
CAS:<p>CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.</p>Fórmula:C28H27N7OPureza:99.58%Cor e Forma:SolidPeso molecular:477.56FGFR4-IN-10
<p>FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.</p>Fórmula:C20H19F3N6O3Cor e Forma:SolidPeso molecular:448.4AZ8010
CAS:<p>AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.</p>Fórmula:C27H34N4O3Cor e Forma:SolidPeso molecular:462.58FGFR1 inhibitor-17
CAS:<p>FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.</p>Fórmula:C16H13ClN2O3Cor e Forma:SolidPeso molecular:316.739
