Receptor do Factor de Crescimento Fibroblasto (FGFR)
Os inibidores de FGFR (receptores do fator de crescimento de fibroblastos) são terapias direcionadas que bloqueiam a atividade dos FGFRs, que estão envolvidos na proliferação celular, diferenciação e angiogênese. A sinalização de FGFR contribui para a formação de novos vasos sanguíneos em tumores, promovendo seu crescimento e sobrevivência. Inibir FGFR pode, portanto, reduzir a angiogênese e a progressão tumoral. Na CymitQuimica, oferecemos uma gama de inibidores de FGFR de alta qualidade para apoiar sua pesquisa em câncer, biologia do desenvolvimento e angiogênese.
Foram encontrados 180 produtos de "Receptor do Factor de Crescimento Fibroblasto (FGFR)"
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MAX-40279 hemifumarate
CAS:MAX-40279 hemifumarate inhibits FLT3 and FGFR kinases, showing promise for AML treatment.Fórmula:C48H50F2N12O6S2Cor e Forma:SolidPeso molecular:993.12ARQ 069
CAS:ARQ 069 inhibits FGFR2 phosphorylation concentration-dependently (IC50: 9.7 µM), without affecting β-actin. Preferentially binds inactive FGFR1/2.Fórmula:C18H15N3Pureza:98%Cor e Forma:SolidPeso molecular:273.33FGFR3-IN-2
CAS:FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).Fórmula:C28H39N9O4SCor e Forma:SolidPeso molecular:597.73Rogaratinib
CAS:Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).Fórmula:C23H26N6O3SPureza:99.54%Cor e Forma:SolidPeso molecular:466.56SSR128129E free acid
CAS:SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).Fórmula:C18H16N2O4Pureza:98%Cor e Forma:SolidPeso molecular:324.33FGFR-IN-9
FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).Fórmula:C25H28N6O3SCor e Forma:SolidPeso molecular:492.59FGFR-IN-3
CAS:FGFR-IN-3: potent, oral FGFR modulator, BBB-penetrating, neuroprotective, potential in neurodegeneration study.Fórmula:C18H27F2N5O2Cor e Forma:SolidPeso molecular:383.44Derazantinib Racemate
CAS:Derazantinib Racemate is an oral ATP competitive kinase inhibitor targeting FGFR1/2/3 (IC50s: 4.5/1.8/4.5 nM).Fórmula:C29H29FN4OPureza:98%Cor e Forma:SolidPeso molecular:468.57SUN13837
CAS:SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.Fórmula:C21H29N5O2Cor e Forma:SolidPeso molecular:383.49FGFR3-IN-1
CAS:FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).Fórmula:C28H39N9O3SCor e Forma:SolidPeso molecular:581.73FGFR-IN-7
CAS:FGFR-IN-7: Oral FGFR modulator, crosses blood-brain barrier, neuroprotective, phospholipidosis-resistant, useful for neurodegeneration study.Fórmula:C16H21ClF2N4O2Cor e Forma:SolidPeso molecular:374.81FIIN-4
CAS:FIIN-4 is a covalent inhibitor of FGFR and can be used in studies about metastatic breast cancer.Fórmula:C35H38N8O4Pureza:99.99%Cor e Forma:SolidPeso molecular:634.73TG 100801 Hydrochloride
CAS:TG 100801: prodrug for macular degeneration. TG 100572: inhibits kinases (VEGFRs, FGFRs, PDGFRβ, Src family), with varying IC50s.Fórmula:C33H31Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:616.54FGFR4-IN-11
CAS:FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.Fórmula:C29H29N5O5Cor e Forma:SolidPeso molecular:527.57Infigratinib phosphate
CAS:Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFórmula:C26H34Cl2N7O7PPureza:99.24% - 99.6%Cor e Forma:SolidPeso molecular:658.47MAX-40279 hydrochloride
CAS:MAX-40279 HCl: potent FLT3/FGFR inhibitor; potential in AML research.Fórmula:C22H24ClFN6OSCor e Forma:SolidPeso molecular:474.98FGFR3-IN-5
CAS:FGFR3-IN-5: potent, selective FGFR3 inhibitor. IC50: 3 nM FGFR3, 44 nM FGFR2, 289 nM FGFR1. For cancer research.Fórmula:C24H24FN7O3Cor e Forma:SolidPeso molecular:477.49CAY10583
CAS:CAY10583 is a selective BLT2 agonist that increases TGF-β1 and bFGF, promotes keratinocyte migration, accelerates wound healing in diabetic mice.Fórmula:C25H25NO3Pureza:>99.99% - >99.99%Cor e Forma:SolidPeso molecular:387.47TYRA-200
CAS:TYRA-200, Oral FGFR1/2/3 inhibitor, induces tumor regression in wild-type/mutant FGFR2 models, for intrahepatic cholangiocarcinoma.Fórmula:C23H24FN7O2Cor e Forma:SolidPeso molecular:449.48Atrinositol
CAS:Atrinositol improves energy homeostasis in a mouse model of pancreatic cancer.Fórmula:C6H15O15P3Cor e Forma:SolidPeso molecular:420.1
