ALK
Os inibidores de ALK são compostos que especificamente visam e inibem a quinase do linfoma anaplásico (ALK), uma tirosina quinase receptora envolvida no desenvolvimento e progressão de certos cânceres, incluindo o câncer de pulmão de células não pequenas e o neuroblastoma. Ao inibir ALK, esses compostos bloqueiam vias de sinalização que promovem o crescimento e a sobrevivência das células tumorais. Na CymitQuimica, oferecemos inibidores de ALK para apoiar sua pesquisa em oncologia, terapias direcionadas contra o câncer e transdução de sinal.
Foram encontrados 154 produtos para "ALK".
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F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Fórmula:C22H27ClN8O3SPureza:97.66%Cor e Forma:SolidPeso molecular:519.02LDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Fórmula:C25H24Cl2N6Pureza:99.87%Cor e Forma:SolidPeso molecular:479.4Ref: TM-T35348
5mg70,00€1mL*10mM (DMSO)74,00€10mg90,00€25mg138,00€50mg213,00€100mg318,00€500mg753,00€ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Fórmula:C23H28ClN7O3SPureza:99.51%Cor e Forma:SolidPeso molecular:518.03Ref: TM-T13416
1mg96,00€5mg219,00€1mL*10mM (DMSO)250,00€10mg344,00€25mg587,00€50mg803,00€100mg1.063,00€200mg1.431,00€MS4078
CAS:MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Fórmula:C45H52ClN9O8SPureza:98.74%Cor e Forma:Yellow SolidPeso molecular:914.47Ref: TM-T16153
1mg49,00€2mg66,00€5mg90,00€10mg152,00€1mL*10mM (DMSO)152,00€25mg260,00€50mg416,00€100mg615,00€Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Pureza:SDS-PAGE:95% SEC-HPLC:98.18%Cor e Forma:Transparent LiquidPeso molecular:150 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Fórmula:C23H28BrN7O3SPureza:98.27%Cor e Forma:White SolidPeso molecular:562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Fórmula:C23H28ClN7O3SPureza:99.77% - >99.99%Cor e Forma:SolidPeso molecular:518.03CEP-28122 mesylate salt
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Fórmula:C29H39ClN6O6SPureza:99.79%Cor e Forma:SolidPeso molecular:635.17ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Fórmula:C24H23NO3SPureza:99.83%Cor e Forma:SolidPeso molecular:405.51Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Pureza:98%Cor e Forma:Odour SolidALK-IN-12
CAS:ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Fórmula:C24H30ClN6O2PCor e Forma:SolidPeso molecular:500.97ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Fórmula:C13H13NO3Pureza:99.54%Cor e Forma:SolidPeso molecular:231.25Ref: TM-T203011
5mg34,00€10mg46,00€1mL*10mM (DMSO)49,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Fórmula:C43H47ClN8O7SCor e Forma:SolidPeso molecular:855.4TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Fórmula:C49H60ClN9O10SPureza:98%Cor e Forma:SolidPeso molecular:1002.57SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Fórmula:C43H49Cl2N10O7PPureza:98%Cor e Forma:SolidPeso molecular:919.79ALK-IN-9
CAS:ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Fórmula:C20H21FN6O3Cor e Forma:SolidPeso molecular:412.425Zilurgisertib fumarate
CAS:Zilurgisertib fumarate is a selective ALK2 inhibitor that modulates iron metabolism and improves anemia by inhibiting SMAD phosphorylation and hepcidin production.Fórmula:C30H38N4O3·xC4H4O4Pureza:99.96%Cor e Forma:Yellow SolidPeso molecular:502.66 (free base)ALK2-IN-6
CAS:ALK2-IN-6 is a potent and selective ALK2 inhibitor with an IC50 of 9 nM. ALK2-IN-6 exhibits excellent brain permeability and effectively suppresses bone morphogenetic protein signaling across various preclinical cancer models for the treatment of diffuse intrinsic pontine glioma.Fórmula:C26H31N3O3Pureza:99.97%Cor e Forma:Gray SolidPeso molecular:433.54ALK degrader 2
ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50= 102 nM). It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC).Cor e Forma:Odour SolidFDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Cor e Forma:LiquidRef: TM-L1610
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