ALK
Os inibidores de ALK são compostos que especificamente visam e inibem a quinase do linfoma anaplásico (ALK), uma tirosina quinase receptora envolvida no desenvolvimento e progressão de certos cânceres, incluindo o câncer de pulmão de células não pequenas e o neuroblastoma. Ao inibir ALK, esses compostos bloqueiam vias de sinalização que promovem o crescimento e a sobrevivência das células tumorais. Na CymitQuimica, oferecemos inibidores de ALK para apoiar sua pesquisa em oncologia, terapias direcionadas contra o câncer e transdução de sinal.
Foram encontrados 146 produtos para "ALK".
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F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Fórmula:C22H27ClN8O3SPureza:97.66%Cor e Forma:SolidPeso molecular:519.02LDN-193189 2HCl
CAS:LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Fórmula:C25H24Cl2N6Pureza:99.87%Cor e Forma:SolidPeso molecular:479.4Ref: TM-T35348
5mg70,00€1mL*10mM (DMSO)74,00€10mg90,00€25mg138,00€50mg213,00€100mg318,00€500mg753,00€ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Fórmula:C23H28ClN7O3SPureza:98.32%Cor e Forma:SolidPeso molecular:518.03Ref: TM-T13416
1mg96,00€5mg219,00€1mL*10mM (DMSO)250,00€10mg344,00€25mg587,00€50mg803,00€100mg1.063,00€200mg1.431,00€MS4078
CAS:MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Fórmula:C45H52ClN9O8SPureza:98.74%Cor e Forma:Yellow SolidPeso molecular:914.47Ref: TM-T16153
1mg49,00€2mg66,00€5mg90,00€10mg152,00€1mL*10mM (DMSO)152,00€25mg260,00€50mg416,00€100mg615,00€Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Pureza:SDS-PAGE:95% SEC-HPLC:98.18%Cor e Forma:Transparent LiquidPeso molecular:150 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Fórmula:C23H28BrN7O3SPureza:98.27%Cor e Forma:White SolidPeso molecular:562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Fórmula:C23H28ClN7O3SPureza:99.77% - >99.99%Cor e Forma:SolidPeso molecular:518.03CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Fórmula:C29H39ClN6O6SPureza:99.79%Cor e Forma:SolidPeso molecular:635.17ALK-IN-26
CAS:ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Fórmula:C24H23NO3SPureza:99.83%Cor e Forma:SolidPeso molecular:405.51Ref: TM-T77754
10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar1mg39,00€5mg82,00€TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Fórmula:C49H60ClN9O10SPureza:98%Cor e Forma:SolidPeso molecular:1002.57ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Fórmula:C32H28F2N4O3Cor e Forma:SolidPeso molecular:554.586ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Fórmula:C13H13NO3Pureza:99.54%Cor e Forma:SolidPeso molecular:231.25Ref: TM-T203011
5mg34,00€10mg46,00€1mL*10mM (DMSO)49,00€25mg84,00€50mg120,00€100mg178,00€200mg268,00€CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Fórmula:C43H47ClN8O7SCor e Forma:SolidPeso molecular:855.4ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 for hALK5. Administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. This compound holds potential for research in developing inhalable ALK5 inhibitors.Fórmula:C20H20ClFN6OPeso molecular:414.86SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Fórmula:C43H49Cl2N10O7PPureza:98%Cor e Forma:SolidPeso molecular:919.79Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Pureza:98%Cor e Forma:Odour SolidTL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Fórmula:C45H53ClN10O10SPureza:98%Cor e Forma:SolidPeso molecular:961.49FDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Cor e Forma:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarZilurgisertib fumarate
CAS:Zilurgisertib fumarate is a selective ALK2 inhibitor that modulates iron metabolism and improves anemia by inhibiting SMAD phosphorylation and hepcidin production.Fórmula:C30H38N4O3·xC4H4O4Pureza:99.96%Cor e Forma:Yellow SolidPeso molecular:502.66 (free base)TL13-110
CAS:Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Fórmula:C49H62ClN9O9SCor e Forma:SolidPeso molecular:988.59
