ALK
Os inibidores de ALK são compostos que especificamente visam e inibem a quinase do linfoma anaplásico (ALK), uma tirosina quinase receptora envolvida no desenvolvimento e progressão de certos cânceres, incluindo o câncer de pulmão de células não pequenas e o neuroblastoma. Ao inibir ALK, esses compostos bloqueiam vias de sinalização que promovem o crescimento e a sobrevivência das células tumorais. Na CymitQuimica, oferecemos inibidores de ALK para apoiar sua pesquisa em oncologia, terapias direcionadas contra o câncer e transdução de sinal.
Foram encontrados 146 produtos para "ALK".
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ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Fórmula:C32H28F2N4O3Cor e Forma:SolidPeso molecular:554.586EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Fórmula:C23H18N8Pureza:99.98%Cor e Forma:White SolidPeso molecular:406.44Ref: TM-T38752
1mg124,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg507,00€25mg1.009,00€50mg1.648,00€100mg2.602,00€LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Fórmula:C25H26Cl4N6Pureza:98.21%Cor e Forma:SolidPeso molecular:552.33Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Fórmula:C21H23Cl3FN5OPureza:98.73% - 98.87%Cor e Forma:SolidPeso molecular:486.8Ref: TM-T8399
5mg34,00€1mL*10mM (DMSO)35,00€10mg50,00€25mg78,00€50mg94,00€100mg131,00€200mg162,00€500mg215,00€A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Fórmula:C18H14N4Pureza:98.82% - ≥95%Cor e Forma:SolidPeso molecular:286.33Ref: TM-T2098
1mg40,00€2mg52,00€5mg86,00€1mL*10mM (DMSO)95,00€10mg118,00€25mg200,00€50mg280,00€100mg394,00€200mg580,00€DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Fórmula:C24H20N4OPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:380.44Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Fórmula:C29H39ClN7O2PPureza:97.18% - >99.99%Cor e Forma:White SolidPeso molecular:584.09Ref: TM-T3621
2mg34,00€5mg48,00€1mL*10mM (DMSO)62,00€10mg63,00€25mg92,00€50mg108,00€100mg158,00€200mg227,00€500mg385,00€Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H34N4O2Pureza:98% - 99.94%Cor e Forma:White SolidPeso molecular:482.62Ref: TM-T1936
2mg44,00€5mg65,00€1mL*10mM (DMSO)70,00€10mg82,00€50mg100,00€100mg159,00€200mg245,00€500mg414,00€LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.Fórmula:C25H29N3O3Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:419.52CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Cor e Forma:White SolidPeso molecular:454.56Ref: TM-T9224
1mg124,00€5mg271,00€1mL*10mM (DMSO)324,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Fórmula:C17H13N5Pureza:99.10% - 99.86%Cor e Forma:Gray SolidPeso molecular:287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Cor e Forma:SolidPeso molecular:406.485-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Fórmula:C12H9N3SPureza:97%Cor e Forma:Yellow SolidPeso molecular:227.29Ref: TM-T50042
2mg43,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg90,00€25mg138,00€50mg200,00€100mg301,00€200mg432,00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13% - 99.97%Cor e Forma:Cyan SolidPeso molecular:448.95CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Cor e Forma:White SolidPeso molecular:580.12Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Cor e Forma:SolidPeso molecular:560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Fórmula:C31H34N4O2Pureza:99.45% - 99.79%Cor e Forma:SolidPeso molecular:494.63Ref: TM-T5197
1mg40,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg128,00€25mg205,00€50mg288,00€100mg414,00€200mg578,00€Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Fórmula:C23H26Cl2FN5O3Cor e Forma:SolidPeso molecular:510.39ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Fórmula:C22H16N4OPureza:99.30% - ≥95%Cor e Forma:SolidPeso molecular:352.39ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Fórmula:C22H18BrN7Pureza:99.93%Cor e Forma:SolidPeso molecular:460.33Ref: TM-T9837
1mg93,00€5mg182,00€1mL*10mM (DMSO)215,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€
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