ALK
Os inibidores de ALK são compostos que especificamente visam e inibem a quinase do linfoma anaplásico (ALK), uma tirosina quinase receptora envolvida no desenvolvimento e progressão de certos cânceres, incluindo o câncer de pulmão de células não pequenas e o neuroblastoma. Ao inibir ALK, esses compostos bloqueiam vias de sinalização que promovem o crescimento e a sobrevivência das células tumorais. Na CymitQuimica, oferecemos inibidores de ALK para apoiar sua pesquisa em oncologia, terapias direcionadas contra o câncer e transdução de sinal.
Foram encontrados 154 produtos para "ALK".
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LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Fórmula:C25H26Cl4N6Pureza:98.21%Cor e Forma:SolidPeso molecular:552.33RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Fórmula:C17H13N5Pureza:99.10% - 99.92%Cor e Forma:Gray SolidPeso molecular:287.32Ref: TM-T6337
1mg34,00€2mg46,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg80,00€25mg116,00€50mg169,00€100mg241,00€500mg597,00€GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Cor e Forma:Yellow SolidPeso molecular:532.57Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C30H34N4O2Pureza:98% - 99.94%Cor e Forma:White SolidPeso molecular:482.62Ref: TM-T1936
2mg44,00€5mg65,00€1mL*10mM (DMSO)70,00€10mg82,00€50mg100,00€100mg159,00€200mg245,00€500mg414,00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Cor e Forma:White SolidPeso molecular:580.12Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.67%Cor e Forma:SolidPeso molecular:560.64Ref: TM-T3678
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg84,00€25mg105,00€50mg159,00€100mg268,00€500mg655,00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Fórmula:C31H34N4O2Pureza:99.45% - 99.79%Cor e Forma:SolidPeso molecular:494.63Ref: TM-T5197
1mg40,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg128,00€25mg205,00€50mg288,00€100mg414,00€200mg578,00€LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Cor e Forma:SolidPeso molecular:406.48ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Fórmula:C22H16N4OPureza:99.30% - ≥95%Cor e Forma:SolidPeso molecular:352.39LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.Fórmula:C25H29N3O3Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:419.52ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Fórmula:C22H18BrN7Pureza:99.93%Cor e Forma:SolidPeso molecular:460.33AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13% - 99.97%Cor e Forma:Cyan SolidPeso molecular:448.95GW788388
CAS:GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.Fórmula:C25H23N5O2Pureza:98.03% - 99.58%Cor e Forma:SolidPeso molecular:425.48K02288
CAS:K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.Fórmula:C20H20N2O4Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:352.38CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Cor e Forma:White SolidPeso molecular:454.56Ref: TM-T9224
1mg124,00€5mg271,00€1mL*10mM (DMSO)324,00€10mg408,00€25mg672,00€50mg945,00€100mg1.279,00€5-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Fórmula:C12H9N3SPureza:97%Cor e Forma:Yellow SolidPeso molecular:227.29Ref: TM-T50042
2mg43,00€5mg60,00€1mL*10mM (DMSO)60,00€10mg90,00€25mg138,00€50mg200,00€100mg301,00€200mg432,00€CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Fórmula:C26H28N4O2Pureza:97.76%Cor e Forma:White SolidPeso molecular:428.53Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Fórmula:C21H23Cl3FN5OPureza:98.73% - 98.87%Cor e Forma:SolidPeso molecular:486.8Ref: TM-T8399
5mg34,00€1mL*10mM (DMSO)35,00€10mg50,00€25mg78,00€50mg94,00€100mg131,00€200mg162,00€500mg215,00€DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Fórmula:C24H20N4OPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:380.44Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Fórmula:C21H22Cl2FN5OPureza:99% - 99.87%Cor e Forma:White SolidPeso molecular:450.34
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