ALK
Os inibidores de ALK são compostos que especificamente visam e inibem a quinase do linfoma anaplásico (ALK), uma tirosina quinase receptora envolvida no desenvolvimento e progressão de certos cânceres, incluindo o câncer de pulmão de células não pequenas e o neuroblastoma. Ao inibir ALK, esses compostos bloqueiam vias de sinalização que promovem o crescimento e a sobrevivência das células tumorais. Na CymitQuimica, oferecemos inibidores de ALK para apoiar sua pesquisa em oncologia, terapias direcionadas contra o câncer e transdução de sinal.
Foram encontrados 112 produtos de "ALK"
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LDN-212854
CAS:<p>LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.</p>Fórmula:C25H22N6Pureza:98% - 98.71%Cor e Forma:SolidPeso molecular:406.48Blu-782
CAS:<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Fórmula:C31H42N6O4Pureza:99.51%Cor e Forma:SolidPeso molecular:562.7SB 525334
CAS:<p>SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).</p>Fórmula:C21H21N5Pureza:98.39% - ≥95%Cor e Forma:SolidPeso molecular:343.42LDN-193189 HCl
CAS:<p>LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.</p>Fórmula:C25H22N6·HClPureza:99.49% - 99.53%Cor e Forma:SolidPeso molecular:442.94Vactosertib Hydrochloride
CAS:<p>Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.</p>Fórmula:C22H19ClFN7Pureza:98.03%Cor e Forma:SolidPeso molecular:435.89A 83-01 sodium salt
CAS:<p>A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.</p>Fórmula:C25H19N5NaSCor e Forma:SolidPeso molecular:444.51AZ 12799734
CAS:<p>AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.</p>Fórmula:C18H18N4O3SPureza:98.23%Cor e Forma:SolidPeso molecular:370.43SB-505124 hydrochloride
CAS:<p>SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.</p>Fórmula:C20H22ClN3O2Pureza:98.71%Cor e Forma:SolidPeso molecular:371.86Itacnosertib
CAS:<p>Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells,antitumor and antileukemic.</p>Fórmula:C26H28N8OPureza:99.38%Cor e Forma:SolidPeso molecular:468.55ALK5-IN-79
CAS:<p>ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.</p>Fórmula:C23H27N7OCor e Forma:SolidPeso molecular:417.51KRCA-0713
CAS:<p>KRCA-0713 is a ALK inhibitor.</p>Fórmula:C26H32ClN5O3SPureza:98%Cor e Forma:SolidPeso molecular:530.08WY-135
CAS:<p>WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).</p>Fórmula:C28H34ClN9O3SPureza:98%Cor e Forma:SolidPeso molecular:612.15ALK2-IN-5
CAS:<p>ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].</p>Fórmula:C24H32N8O2Cor e Forma:SolidPeso molecular:464.56ALK-IN-5
CAS:<p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>Fórmula:C24H25FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:464.49TGFBR1-IN-1
CAS:<p>TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).</p>Fórmula:C23H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:427.48EML4-ALK kinase inhibitor 1
CAS:<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Fórmula:C31H48N8O3Pureza:99.62%Cor e Forma:SolidPeso molecular:580.76ALK2-IN-2
CAS:<p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>Fórmula:C28H27N5O2SPureza:99.55%Cor e Forma:SolidPeso molecular:497.61OD36
CAS:<p>OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.</p>Fórmula:C16H15ClN4O2Pureza:99.89%Cor e Forma:SolidPeso molecular:330.77OD36 hydrochloride
CAS:<p>OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently</p>Fórmula:C16H16Cl2N4O2Pureza:99.85%Cor e Forma:SolidPeso molecular:367.23J-1048
CAS:<p>J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/</p>Fórmula:C23H17FN6S2Cor e Forma:SolidPeso molecular:460.55
