c-Fms
Os inibidores de c-Fms têm como alvo o Receptor do Fator Estimulador de Colônias-1 (c-Fms), uma tirosina quinase envolvida na regulação de macrófagos e outras células imunológicas. A sinalização de c-Fms desempenha um papel na proliferação, diferenciação e sobrevivência dessas células. A desregulação do c-Fms está associada a doenças como câncer, condições inflamatórias e osteoporose. Na CymitQuimica, oferecemos inibidores de c-Fms para apoiar sua pesquisa em imunologia, oncologia e doenças inflamatórias.
Foram encontrados 105 produtos de "c-Fms"
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Edicotinib
CAS:Edicotinib (JNJ-527) is a blood-brain permeable, selective CSF-1R inhibitor, with lesser inhibitory effects on KIT and FLT3.Cost-effective and quality-assured.
Fórmula:C27H35N5O2Pureza:98.58% - 99.72%Cor e Forma:SolidPeso molecular:461.6Lacnotuzumab
CAS:Lacnotuzumab (MCS110) is a humanized monoclonal antibody targeting CSF-1, which can be used in research on retinal diseases.Pureza:>95%Cor e Forma:LiquidPeso molecular:144.8 kDaCSF1R-IN-2
CAS:CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).Fórmula:C20H20FN7O2Pureza:99.29%Cor e Forma:SolidPeso molecular:409.42CSF1R-IN-1
CAS:CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.Fórmula:C25H20F3N5O2Pureza:97.02% - 98.56%Cor e Forma:SolidPeso molecular:479.45Ref: TM-T10894
1mg88,00€5mg200,00€10mg309,00€25mg522,00€50mg747,00€100mg1.035,00€200mg1.378,00€1mL*10mM (DMSO)219,00€Emactuzumab
CAS:Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has
Pureza:SDS-PAGE:98.3%;SEC-HPLC:97.3%Cor e Forma:LiquidPeso molecular:144.4 kDaMavrilimumab
CAS:Mavrilimumab (CAM 3001), a monoclonal antibody, blocks GM-CSF signaling, potentially reducing inflammation in rheumatoid arthritis.
Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:143.2 kDaSotuletinib hydrochloride
CAS:Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM),for ALS and TNBC.Fórmula:C20H23ClN4O3SPureza:98.812%Cor e Forma:SolidPeso molecular:434.94PLX647 dihydrochloride
CAS:PLX647 dihydrochloride: potent FMS/KIT inhibitor (IC50: 28/16 nM), highly selective, limited FLT3/KDR activity, oral use.Fórmula:C21H19Cl2F3N4Cor e Forma:SolidPeso molecular:455.31Eflapegrastim
CAS:Eflapegrastim: humanized IgG4 antibody and G-CSF that boosts neutrophils and shortens neutropenia.Cor e Forma:LiquidGENZ-882706(Raceme)
CAS:GENZ-882706(Raceme) is the racemate of GENZ-882706.Fórmula:C26H25N5O3Pureza:98%Cor e Forma:SolidPeso molecular:455.51cFMS Receptor Inhibitor IV
CAS:cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.
Fórmula:C22H26N4O2Pureza:99.70%Cor e Forma:SolidPeso molecular:378.47AMG-820
AMG-820 is a human antibody targeting CSF-1R, inhibiting the binding of ligands CSF1 and IL34, and preventing subsequent ligand-induced receptor activation. For AMG-820's isotype control, refer to [Human IgG2 kappa, Isotype Control].Cor e Forma:Odour LiquidGimsilumab
CAS:Gimsilumab (MORAb-022) is an anti-c-Fms humanized monoclonal antibody for the study of inflammation and hypoxemia caused by COVID-19.Pureza:99.49% (SEC-HPLC) - 99.49% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.8 kDaM4205
CAS:M4205 is an inhibitor of c-Kit exhibiting high activity on c-Kit mutations in exons 11, 13, 17.Fórmula:C29H32N8OPureza:99.07%Cor e Forma:SolidPeso molecular:508.62Ref: TM-T9689
1mg50,00€5mg110,00€10mg170,00€25mg290,00€50mg414,00€100mg572,00€200mg772,00€1mL*10mM (DMSO)122,00€Antifibrotic agent 1
Antifibrotic agent 1 is an orally active medication designed to treat idiopathic pulmonary fibrosis (IPF). It effectively mitigates IPF-related processes, including TGF-β-induced epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT), as well as profibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α, and Src family kinases (SFKs), while sparing VEGFR, FGFR, and Abl to minimize off-target toxicity. In a bleomycin (BLM)-induced pulmonary fibrosis mouse model, it demonstrates strong antifibrotic activity.Fórmula:C27H23ClN6O2Cor e Forma:SolidPeso molecular:498.1571CSF1R-IN-17
CSF1R-IN-17 (compound 9) is a potent, selective antagonist of CSF1R, exhibiting an inhibition concentration half-maximum (IC50) of 0.2 nM.Fórmula:C20H25N5O2Pureza:98%Cor e Forma:SolidPeso molecular:367.44PXB17
PXB17 inhibits CSF1R activation (IC50= 1.7 nM) by blocking the PI3K/AKT/mTORC1 signaling pathway. It is effective orally, significantly suppresses the growth of colorectal cancer (CRC), enhances the efficacy of PD-1 monoclonal antibodies (PD-1mAb), and reduces the recurrence of CRC tumors.Fórmula:C29H35N7O4Peso molecular:545.27505Adrixetinib TFA
Adrixetinib (TFA) is a protein tyrosine kinase inhibitor that possesses antineoplastic properties [1] [2] [3].Cor e Forma:Odour SolidOtilimab
CAS:Otilimab, a humanized monoclonal antibody, blocks GM-CSF to reduce inflammation and may treat severe COVID-19 pneumonia.
Pureza:> 95%Cor e Forma:LiquidPeso molecular:142.22 kDaPyrithyldione
CAS:Pyrithyldione is a sedative-hypnotic agent known to potentially induce agranulocytosis.Fórmula:C9H13NO2Cor e Forma:SolidPeso molecular:167.21CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:57.4 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Ref: TM-TMPK-00415
5µg91,00€10µg150,00€20µg239,00€50µg471,00€100µg779,00€200µg1.410,00€500µg3.018,00€Anti-CSF1R Antibody (8O797)
Anti-CSF1R Antibody (8O797) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (8O797) can be used in ELISA.Cor e Forma:Odour LiquidCSF1R Protein, Human, Recombinant (His & GST)
CSF1R Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag.Cor e Forma:Lyophilized PowderPeso molecular:76 kDa (predicted); 75 kDa (reducing conditions)CSF1R Protein, Human, Recombinant (mFc)
CSF1R Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag.Cor e Forma:Lyophilized PowderPeso molecular:81.5 kDa (predicted)Ref: TM-TMPY-05264
1mg2.099,00€5µg47,00€10µg65,00€20µg94,00€50µg167,00€100µg334,00€200µg499,00€500µg1.046,00€CSF1R Protein, Human, Recombinant (Domain I&II&III, His)
CSF1R Protein, Human, Recombinant (Domain I&II&III, His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:31.1 kDa (predicted)CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated
CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:83.04 kDa (predicted); 110.87 kDa (reducing conditions)CSF1R Protein (Ala299-Glu512), Human, Recombinant (His)
CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:25.3 kDa (predicted)CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
CSF1R Protein (Met1-Glu512), Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:SDS-PAGE: 97.7%; SEC-HPLC: 99.7%Cor e Forma:Lyophilized PowderPeso molecular:56 kDa (predicted); 85-95 kDa (reducing condition, due to glycosylation)PLX647
CAS:PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).Fórmula:C21H17F3N4Pureza:99.38%Cor e Forma:SolidPeso molecular:382.38Ref: TM-T1925
2mg39,00€5mg57,00€10mg86,00€25mg127,00€50mg178,00€100mg264,00€200mg389,00€1mL*10mM (DMSO)60,00€CSF1R Protein, Human, Recombinant (His & Avi)
M-CSFR/CSF1R/CD115 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:57.4 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-CSF1R Antibody (4Y587)
Anti-CSF1R Antibody (4Y587) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (4Y587) can be used in FCM.Cor e Forma:Odour LiquidAnti-CSF1R Antibody (5C535)
Anti-CSF1R Antibody (5C535) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (5C535) can be used in ELISA.Cor e Forma:Odour LiquidAnti-CSF1R Antibody (1R707)
Anti-CSF1R Antibody (1R707) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (1R707) can be used in ELISA.Cor e Forma:Odour LiquidAnti-CSF1R Antibody (2I506)
Anti-CSF1R Antibody (2I506) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (2I506) can be used in ELISA.Cor e Forma:Odour LiquidAnti-CSF1R Antibody-FITC (4Y587)
Anti-CSF1R Antibody-FITC (4Y587) is a FITC-conjugated Mouse antibody targeting CSF1R. Anti-CSF1R Antibody-FITC (4Y587) can be used in FCM.Cor e Forma:Odour LiquidAnti-CSF1R Antibody (7V18)
Anti-CSF1R Antibody (7V18) is a Rabbit antibody targeting CSF1R. Anti-CSF1R Antibody (7V18) can be used in ELISA.Cor e Forma:Odour LiquidCSF1R Protein, Human, Recombinant
CSF1R Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 55.1 kDa and the accession number is P07333-1.Cor e Forma:Lyophilized PowderPeso molecular:55.1 kDa (predicted); 80-90 kDa (reducing condition, due to glycosylation)Anti-CSF1R Antibody (5B661)
Anti-CSF1R Antibody (5B661) is a Mouse antibody targeting CSF1R. Anti-CSF1R Antibody (5B661) can be used in ELISA,ELISA(Cap).Cor e Forma:Odour LiquidCSF1R Protein, Cynomolgus, Recombinant (His)
M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.Cor e Forma:Lyophilized PowderPeso molecular:56.3 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:57.76 kDa (predicted); 82.52 kDa (reducing conditions)CSF1R Protein, Human, Recombinant (hFc)
CSF1R Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:81.2 kDa (predicted)Ref: TM-TMPY-05429
1mg2.931,00€5µg57,00€10µg90,00€20µg126,00€50µg244,00€100µg472,00€200µg691,00€500µg1.488,00€Ki20227
CAS:Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).Fórmula:C24H24N4O5SPureza:98.97% - 99.88%Cor e Forma:SolidPeso molecular:480.54Ref: TM-T4315
1mg44,00€5mg90,00€10mg145,00€25mg268,00€50mg439,00€100mg700,00€200mg954,00€1mL*10mM (DMSO)90,00€Edicotinib HCl
CAS:Edicotinib (JNJ-40346527), an oral CSF1R inhibitor, may block FMS autophosphorylation, impeding tumor cell growth.Fórmula:C27H36ClN5O2Cor e Forma:SolidPeso molecular:498.07Sotuletinib
CAS:Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.Fórmula:C20H22N4O3SPureza:97.43% - 99.82%Cor e Forma:SolidPeso molecular:398.48Ref: TM-T6119
1mg37,00€5mg79,00€10mg111,00€25mg172,00€50mg216,00€100mg378,00€500mg868,00€1mL*10mM (DMSO)87,00€Dovitinib
CAS:Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.
Fórmula:C21H21FN6OPureza:99.35% - 99.92%Cor e Forma:SolidPeso molecular:392.43GW2580
CAS:GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.Fórmula:C20H22N4O3Pureza:99.48% - >99.99%Cor e Forma:SolidPeso molecular:366.41Nampt-IN-1
CAS:Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Fórmula:C20H25N3O5SPureza:99.28% - 99.4%Cor e Forma:SolidPeso molecular:419.49Ref: TM-T4376
1mg37,00€2mg49,00€5mg79,00€10mg130,00€25mg245,00€50mg409,00€100mg605,00€1mL*10mM (DMSO)87,00€OSI-930
CAS:OSI-930 is an oral c-Kit/VEGFR-2 inhibitor targeting tumor growth and angiogenesis.Fórmula:C22H16F3N3O2SPureza:99.67%Cor e Forma:SolidPeso molecular:443.44cFMS Receptor Inhibitor II
CAS:cFMS Receptor Inhibitor II is a CSF1R kinase inhibitorFórmula:C23H20N4OPureza:99.8%Cor e Forma:SolidPeso molecular:368.43Ref: TM-T5586
1mg49,00€2mg65,00€5mg97,00€10mg154,00€25mg255,00€50mg376,00€100mg547,00€1mL*10mM (DMSO)106,00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Cor e Forma:SolidPeso molecular:419.48GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Fórmula:C21H23N7O2S·HClPureza:99.87%Cor e Forma:SolidPeso molecular:473.98PRN1371
CAS:PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Fórmula:C26H30Cl2N6O4Pureza:98.65%Cor e Forma:SolidPeso molecular:561.46Ref: TM-TQ0015
1mg77,00€2mg100,00€5mg166,00€10mg289,00€25mg492,00€50mg710,00€100mg973,00€1mL*10mM (DMSO)200,00€PLX5622
CAS:PLX5622 is a selective, orally active and blood-brain barrier permeable CSF1R inhibitor. PLX5622 induces elimination of microglia. Cost effective and quality assured.Fórmula:C21H19F2N5OPureza:98% - 99.92%Cor e Forma:SolidPeso molecular:395.41Ref: TM-T7100
1mg43,00€5mg81,00€10mg118,00€25mg230,00€50mg385,00€100mg502,00€200mg710,00€1mL*10mM (DMSO)77,00€AZD7507
CAS:AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.Fórmula:C23H27FN6O3Pureza:99.55% - 99.78%Cor e Forma:SolidPeso molecular:454.5Ref: TM-T14380
1mg50,00€5mg110,00€10mg161,00€25mg289,00€50mg419,00€100mg583,00€200mg787,00€1mL*10mM (DMSO)127,00€Vimseltinib
CAS:Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Fórmula:C23H25N7O2Pureza:99.05% - 99.57%Cor e Forma:SolidPeso molecular:431.49Ref: TM-T10652
1mg87,00€5mg178,00€10mg295,00€25mg505,00€50mg690,00€100mg888,00€1mL*10mM (DMSO)203,00€Linifanib
CAS:Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFórmula:C21H18FN5OPureza:98% - 98.24%Cor e Forma:SolidPeso molecular:375.4Ref: TM-T2514
5mg48,00€10mg80,00€25mg119,00€50mg178,00€100mg259,00€200mg477,00€500mg772,00€1mL*10mM (DMSO)50,00€Pexidartinib
CAS:Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potentialFórmula:C20H15ClF3N5Pureza:98.34% - 99.45%Cor e Forma:SolidPeso molecular:417.81Ref: TM-T2115
5mg46,00€10mg58,00€25mg90,00€50mg114,00€100mg145,00€200mg192,00€500mg333,00€1mL*10mM (DMSO)49,00€Seralutinib
CAS:Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.Fórmula:C27H27N5O3Pureza:99.09%Cor e Forma:SolidPeso molecular:469.54Ref: TM-T8900
1mg47,00€2mg62,00€5mg92,00€10mg137,00€25mg236,00€50mg313,00€100mg497,00€1mL*10mM (DMSO)92,00€Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Fórmula:C20H28ClN7O3SPureza:99.85%Cor e Forma:SolidPeso molecular:482Cabiralizumab
CAS:Cabiralizumab is an anti-CSF1R monoclonal antibody that enhances T cell infiltration, inhibits osteoclasts, and is used in RA and immune-oncology research.Pureza:95% - 98.2% (SDS-PAGE); 98.1% (SEC-HPLC)Cor e Forma:LiquidTrabikibart
CAS:Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.Pureza:95% - 95.6% (SDS-PAGE); 99.3% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.64 kDaNamilumab
CAS:Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.Pureza:95%Cor e Forma:LiquidCSF1R-IN-19
CAS:CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].Fórmula:C20H27N7OCor e Forma:SolidPeso molecular:381.47Sotuletinib dihydrochloride
CAS:Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.Fórmula:C20H24Cl2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:471.4c-Fms-IN-9
CAS:c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45Leustroducsin A
CAS:Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.Fórmula:C32H52NO10PCor e Forma:SolidPeso molecular:641.73c-Fms-IN-7
CAS:c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).Fórmula:C26H24N6OSPureza:98%Cor e Forma:SolidPeso molecular:468.57c-Fms-IN-8
CAS:c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.Fórmula:C27H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:462.54JNJ-28312141
CAS:JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.Fórmula:C26H32N6O2Pureza:98%Cor e Forma:SolidPeso molecular:460.57CSF1R-IN-4
CAS:CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)Fórmula:C23H20N6O3Cor e Forma:SolidPeso molecular:428.44c-Fms-IN-10
CAS:c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.Fórmula:C22H19N7OSPureza:98%Cor e Forma:SolidPeso molecular:429.5CSF1R-IN-13
CAS:CSF1R-IN-13: potent cancer research CSF1R inhibitor impacting cell growth regulation.Fórmula:C21H20N4O3Cor e Forma:SolidPeso molecular:376.41CSF1R-IN-8
CAS:CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).Fórmula:C24H22N4O4Cor e Forma:SolidPeso molecular:430.46CSF1R-IN-10
CAS:CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).Fórmula:C25H22N4O3Cor e Forma:SolidPeso molecular:426.47Leustroducsin C
CAS:Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.Fórmula:C34H56NO10PCor e Forma:SolidPeso molecular:669.78CSF1R-IN-14
CAS:CSF1R-IN-14, an isoindolinone derivative, powerfully inhibits CSF1R, with potential in cancer research. See WO2019134662A1, compound 1.Fórmula:C23H22F3N5OCor e Forma:SolidPeso molecular:441.45CSF1R-IN-12
CAS:CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.Fórmula:C21H17F3N4OCor e Forma:SolidPeso molecular:398.38CSF1R-IN-7
CAS:CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.Fórmula:C22H22N6O3Pureza:99.41% - 99.93%Cor e Forma:SolidPeso molecular:418.45CSF1R-IN-9
CAS:CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).Fórmula:C26H26N4O2Cor e Forma:SolidPeso molecular:426.51CSF1R-IN-6
CAS:CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.
Fórmula:C20H18N8O3Cor e Forma:SolidPeso molecular:418.41c-Fms-IN-2
CAS:c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).Fórmula:C19H21N3O3Pureza:99.56%Cor e Forma:SolidPeso molecular:339.39Ref: TM-T10775
1mg92,00€5mg241,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€1mL*10mM (DMSO)180,00€ABD-295
CAS:ABD-295, a biphenylsulfide derivative, inhibits osteoclasts and prevents bone loss in vitro and in vivo.Fórmula:C17H19F2NO3SPureza:98%Cor e Forma:SolidPeso molecular:355.4c-Fms-IN-6
CAS:c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).Fórmula:C22H25N7O2Pureza:98%Cor e Forma:SolidPeso molecular:419.48IACS-9439
CAS:IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.Fórmula:C23H26ClN7O3SPureza:98%Cor e Forma:SolidPeso molecular:516.02c-Fms-IN-1
CAS:c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).Fórmula:C22H27N5O2Pureza:99.94%Cor e Forma:SolidPeso molecular:393.48Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.
Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47c-Fms-IN-3
CAS:c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.Fórmula:C23H30N6OPureza:99.87%Cor e Forma:SolidPeso molecular:406.52Ref: TM-T10649
1mg52,00€5mg105,00€10mg161,00€25mg264,00€50mg358,00€100mg522,00€1mL*10mM (DMSO)110,00€c-Fms-IN-13
CAS:c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.Fórmula:C22H26N4O2Pureza:99.93% - 99.97%Cor e Forma:SolidPeso molecular:378.47Pimicotinib
CAS:Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Fórmula:C22H24N6O3Pureza:99.8%Cor e Forma:SolidPeso molecular:420.46Ref: TM-T79157
1mg52,00€5mg111,00€10mg170,00€25mg329,00€50mg528,00€100mg843,00€1mL*10mM (DMSO)156,00€CSF1R-IN-3
CAS:CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.Fórmula:C30H38N8O4Pureza:98.4%Cor e Forma:SolidPeso molecular:574.67Ref: TM-T64066
1mg101,00€5mg245,00€10mg358,00€25mg665,00€50mg973,00€100mg1.395,00€1mL*10mM (DMSO)309,00€Ataquimast
CAS:Ataquimast is used in curing advanced receptor-positive breast cancer.Fórmula:C11H14ClN3OPureza:99.92%Cor e Forma:SolidPeso molecular:239.7Ref: TM-T30190
1mg64,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€1mL*10mM (DMSO)116,00€JTE-952
CAS:JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.Fórmula:C30H34N2O6Pureza:98%Cor e Forma:SolidPeso molecular:518.6c-Fms-IN-14
CAS:c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].Fórmula:C26H24N6OPureza:98%Cor e Forma:SolidPeso molecular:436.51Axl/Mer/CSF1R-IN-2
CAS:Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].Fórmula:C24H22F3N5O5Cor e Forma:SolidPeso molecular:517.46CSF1R-IN-5
CAS:CSF1R-IN-5: Potent CSF1R inhibitor, may alter TAM/glioma inflammatory exchanges, potential cancer research tool. (WO2021197276A1, Compound 11)Fórmula:C22H19N7O3Cor e Forma:SolidPeso molecular:429.43Axl/Mer/CSF1R-IN-1
CAS:Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds)Fórmula:C25H24F3N5O5Cor e Forma:SolidPeso molecular:531.48Adrixetinib
CAS:Adrixetinib is an inhibitor of protein tyrosine kinase with antineoplastic activity .Fórmula:C25H24F3N5O5Cor e Forma:SolidPeso molecular:531.48ARRY-382
CAS:ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.
Fórmula:C32H36N8O2Pureza:99.76%Cor e Forma:SolidPeso molecular:564.68Enrupatinib
CAS:Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.Fórmula:C27H26N6O3Cor e Forma:SolidPeso molecular:482.53c-Fms-IN-15
CAS:c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.Fórmula:C29H28F3N7O2Peso molecular:563.57
