c-RET
Os inibidores de c-RET têm como alvo o proto-oncogene RET (Rearranged during Transfection), que codifica uma tirosina quinase receptora envolvida no crescimento, diferenciação e sobrevivência celular. A ativação anormal da sinalização RET pode levar à proliferação celular descontrolada e à resistência à apoptose, contribuindo para o desenvolvimento de cânceres como o carcinoma medular da tireoide e o câncer de pulmão de células não pequenas. A inibição de c-RET pode induzir apoptose em células cancerígenas e é uma abordagem promissora na terapia oncológica direcionada. Na CymitQuimica, oferecemos uma variedade de inibidores de c-RET de alta qualidade para apoiar sua pesquisa em oncologia, transdução de sinais e apoptose.
Foram encontrados 60 produtos de "c-RET"
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RET-IN-9
CAS:RET-IN-9 is a potent RET kinase inhibitor, potentially useful for studying RET-related diseases, including lung and thyroid cancer.Fórmula:C26H27N9OCor e Forma:SolidPeso molecular:481.55FHND5071 (1H)
CAS:FHND5071 (1H) is a selective inhibitor of RET (rearranged during transfection) tyrosine kinase. It shows potential for research applications in RET-driven cancers, such as thyroid and lung cancer.Fórmula:C30H33N9OCor e Forma:SolidPeso molecular:535.64LRRK2-IN-17
CAS:LRRK2-IN-17 is an orally active LRRK2 inhibitor with IC50 values of 3.5 nM for WT and 3.3 nM for G2019S, and it also inhibits RET kinase with an IC50 of 59 nM. LRRK2-IN-17 is utilized in research related to cancer and Parkinson's disease (PD).Fórmula:C18H18N8Cor e Forma:SolidPeso molecular:346.39RET-IN-10
CAS:RET-IN-10: Potent RET inhibitor, may treat congenital megacolon and tumors (Patent WO2021135938A1, compound 18).Fórmula:C29H28N8OSCor e Forma:SolidPeso molecular:536.65TAS05567
CAS:TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM).Fórmula:C21H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:439.51RET-IN-30
CAS:RET-IN-30 (Compound 28) is a RET inhibitor that exhibits inhibitory activity against both wild-type RET and some of its mutants. It is capable of inhibiting the proliferation of A549 cells and demonstrates antitumor properties.Fórmula:C26H26FN5OCor e Forma:SolidPeso molecular:443.52RET-IN-7
CAS:RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice throughFórmula:C22H24ClFN6O2Cor e Forma:SolidPeso molecular:458.92RET-IN-1
CAS:RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).Fórmula:C29H31N9O3Pureza:98%Cor e Forma:SolidPeso molecular:553.61WF-47-JS03
WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.
Fórmula:C30H38N6O2Cor e Forma:SolidPeso molecular:514.66Enbezotinib
CAS:Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.Fórmula:C21H21FN6O3Pureza:99.84%Cor e Forma:SolidPeso molecular:424.43Ref: TM-T62285
1mg77,00€5mg166,00€10mg253,00€25mg414,00€50mg567,00€100mg745,00€1mL*10mM (DMSO)182,00€
