c-Kit
Os inibidores de c-Kit são compostos que bloqueiam a atividade do Receptor do Fator de Células-Tronco (c-Kit), uma tirosina quinase que desempenha um papel crucial na sobrevivência, proliferação e diferenciação celular, particularmente em células hematopoéticas. As mutações em c-Kit estão ligadas a vários tipos de câncer, incluindo tumores estromais gastrointestinais (GIST) e leucemia. Na CymitQuimica, oferecemos inibidores de c-Kit para apoiar sua pesquisa em oncologia, hematologia e biologia de células-tronco.
Foram encontrados 101 produtos de "c-Kit"
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Ki20227
CAS:<p>Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).</p>Fórmula:C24H24N4O5SPureza:98.97% - 99.88%Cor e Forma:SolidPeso molecular:480.54Flumatinib
CAS:<p>Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.</p>Fórmula:C29H29F3N8OPureza:99.39% - 99.95%Cor e Forma:SolidPeso molecular:562.59AZD2932
CAS:<p>AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.</p>Fórmula:C24H25N5O4Pureza:97.71% - 98.37%Cor e Forma:SolidPeso molecular:447.49AZD3229 Tosylate
CAS:<p>AZD3229 Tosylate is a highly potent inhibitor targeting mutant forms of the pan-KIT enzyme, with a primary application in the treatment of gastrointestinal</p>Fórmula:C31H34FN7O6SCor e Forma:SolidPeso molecular:651.71Midostaurin
CAS:<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Fórmula:C35H30N4O4Pureza:97.61% - >99.99%Cor e Forma:SolidPeso molecular:570.64Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Fórmula:C24H27FN6O4Pureza:99.54% - 99.77%Cor e Forma:SolidPeso molecular:482.51Tandutinib
CAS:<p>Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3</p>Fórmula:C31H42N6O4Pureza:99.45% - ≥98%Cor e Forma:White SolidPeso molecular:562.7Vimseltinib
CAS:<p>Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).</p>Fórmula:C23H25N7O2Pureza:99.05% - 99.57%Cor e Forma:SolidPeso molecular:431.49SKLB4771
CAS:<p>SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.</p>Fórmula:C25H27N7O3S2Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:537.66AZD3229
CAS:<p>AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.</p>Fórmula:C24H26FN7O3Pureza:98.83%Cor e Forma:SolidPeso molecular:479.51c-Kit-IN-1
CAS:<p>c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).</p>Fórmula:C26H21F2N5O3Pureza:98.72% - 98.73%Cor e Forma:SolidPeso molecular:489.47Imatinib
CAS:<p>Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit</p>Fórmula:C29H31N7OPureza:99.42% - 99.94%Cor e Forma:Off White PowderPeso molecular:493.6Telatinib
CAS:<p>Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.</p>Fórmula:C20H16ClN5O3Pureza:97.61% - 99.81%Cor e Forma:SolidPeso molecular:409.83Linifanib
CAS:<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Fórmula:C21H18FN5OPureza:98% - 98.24%Cor e Forma:SolidPeso molecular:375.4GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Fórmula:C21H23N7O2S·HClPureza:99.87%Cor e Forma:SolidPeso molecular:473.98N-Desethylsunitinib hydrochloride
CAS:<p>N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.</p>Fórmula:C20H24ClFN4O2Pureza:99.42%Cor e Forma:SolidPeso molecular:406.88Motesanib
CAS:<p>Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.</p>Fórmula:C22H23N5OPureza:98% - 99.09%Cor e Forma:SolidPeso molecular:373.45Regorafenib
CAS:<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Fórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:482.82Lenvatinib mesylate
CAS:<p>Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.</p>Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Cor e Forma:SolidPeso molecular:522.96Tyrphostin AG1296
CAS:<p>Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.</p>Fórmula:C16H14N2O2Pureza:99.94% - >99.99%Cor e Forma:SolidPeso molecular:266.29Dovitinib lactate hydrate
CAS:<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Fórmula:C24H27FN6O4Pureza:99.82%Cor e Forma:SolidPeso molecular:482.51Amuvatinib
CAS:<p>Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.</p>Fórmula:C23H21N5O3SPureza:99.38% - >99.99%Cor e Forma:SolidPeso molecular:447.51Pexidartinib
CAS:<p>Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential</p>Fórmula:C20H15ClF3N5Pureza:98.34% - 99.45%Cor e Forma:SolidPeso molecular:417.81Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Fórmula:C28H24FN3O5Pureza:99.68% - 99.88%Cor e Forma:SolidPeso molecular:501.51Flumatinib mesylate
CAS:<p>Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.</p>Fórmula:C30H33F3N8O4SPureza:99.82%Cor e Forma:SolidPeso molecular:658.69Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Fórmula:C28H25ClFN3O5Pureza:99.97%Cor e Forma:SolidPeso molecular:537.96Dovitinib
CAS:<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Fórmula:C21H21FN6OPureza:99.35% - 99.92%Cor e Forma:SolidPeso molecular:392.43Sitravatinib
CAS:<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>Fórmula:C33H29F2N5O4SPureza:98.9% - 99.85%Cor e Forma:SolidPeso molecular:629.68Masitinib mesylate
CAS:<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Fórmula:C29H34N6O4S2Pureza:97.67% - 98.44%Cor e Forma:SolidPeso molecular:594.75Toceranib
CAS:<p>Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.</p>Fórmula:C22H25FN4O2Pureza:97.14%Cor e Forma:SolidPeso molecular:396.46c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.</p>Cor e Forma:Lyophilized PowderPeso molecular:58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-Mouse CD117 Antibody
<p>Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.</p>Pureza:98%Cor e Forma:Odour SolidBarzolvolimab
CAS:<p>Barzolvolimab (CDX 0159), a humanized IgG1 monoclonal antibody, blocks KIT activation and treats chronic urticaria.</p>Cor e Forma:LiquidBriquilimab
CAS:<p>Briquilimab is a humanized antibody that inhibits the SCF-KIT interaction, inducing mast cell apoptosis for research into inflammatory diseases.</p>Pureza:95% - 95%Cor e Forma:LiquidGW694590A
CAS:<p>GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].</p>Fórmula:C22H19N5O4Cor e Forma:SolidPeso molecular:417.42APcK110
CAS:<p>"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."</p>Fórmula:C20H16FN3O2Cor e Forma:SolidPeso molecular:349.36Bezuclastinib
CAS:<p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>Fórmula:C19H17N5OPureza:99.55%Cor e Forma:SolidPeso molecular:331.37AC710
CAS:<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Fórmula:C31H42N6O4Pureza:99.67%Cor e Forma:SolidPeso molecular:562.7c-Kit-IN-3
CAS:<p>c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).</p>Fórmula:C26H20ClF3N2O4Pureza:99.94%Cor e Forma:SolidPeso molecular:516.9c-Kit-IN-2
CAS:<p>c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (</p>Fórmula:C25H29N9O2SPureza:98%Cor e Forma:SolidPeso molecular:519.62KBP-7018
CAS:<p>KBP-7018: potent tyrosine kinase inhibitor targeting c-KIT, RET, PDGFR with IC50s of 10, 7.6, 25nM.</p>Fórmula:C31H30N4O5Cor e Forma:SolidPeso molecular:538.59Sitravatinib malate
CAS:<p>Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5</p>Fórmula:C37H35F2N5O9SPureza:98%Cor e Forma:SolidPeso molecular:763.76Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47Tafetinib
CAS:<p>Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.</p>Fórmula:C24H29FN4O2Pureza:96.23%Cor e Forma:SolidPeso molecular:424.51Agerafenib hydrochloride
CAS:<p>Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).</p>Fórmula:C24H23ClF3N5O5Pureza:98%Cor e Forma:SolidPeso molecular:553.92Henatinib
CAS:<p>Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.</p>Fórmula:C25H29FN4O4Cor e Forma:SolidPeso molecular:468.52c-Kit-IN-8
CAS:<p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>Fórmula:C24H26FN5O4Cor e Forma:SolidPeso molecular:467.49AMG-25
CAS:<p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>Fórmula:C23H17N5O2Pureza:98.16%Cor e Forma:SolidPeso molecular:395.41Protein kinase inhibitor 10
CAS:<p>Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.</p>Fórmula:C14H9FN6S2Cor e Forma:SolidPeso molecular:344.39c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:58.50 kDa (predicted); 87.1 kDa (reducing conditions)
