c-Kit
Os inibidores de c-Kit são compostos que bloqueiam a atividade do Receptor do Fator de Células-Tronco (c-Kit), uma tirosina quinase que desempenha um papel crucial na sobrevivência, proliferação e diferenciação celular, particularmente em células hematopoéticas. As mutações em c-Kit estão ligadas a vários tipos de câncer, incluindo tumores estromais gastrointestinais (GIST) e leucemia. Na CymitQuimica, oferecemos inibidores de c-Kit para apoiar sua pesquisa em oncologia, hematologia e biologia de células-tronco.
Foram encontrados 101 produtos de "c-Kit"
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c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells.</p>Cor e Forma:Lyophilized PowderPeso molecular:58.60 kDa (predicted). Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.Anti-Mouse CD117 Antibody
<p>Anti-Mouse CD117 Antibody, a rat-derived IgG2b isotype, acts as an inhibitor specific to the mouse CD117 antigen.</p>Pureza:98%Cor e Forma:Odour SolidBarzolvolimab
CAS:<p>Barzolvolimab (CDX 0159), a humanized IgG1 monoclonal antibody, blocks KIT activation and treats chronic urticaria.</p>Cor e Forma:LiquidBriquilimab
CAS:<p>Briquilimab is a humanized antibody that inhibits the SCF-KIT interaction, inducing mast cell apoptosis for research into inflammatory diseases.</p>Pureza:95% - 95%Cor e Forma:LiquidGW694590A
CAS:<p>GW694590A (UNC10112731) functions as a MYC protein stabilizer that enhances the levels of endogenous MYC protein. It also acts on receptor tyrosine kinases, inhibiting DDR2, KIT, and PDGFRα by 81%, 68%, and 67% at a concentration of 1 μM, respectively. As a protein kinase inhibitor, GW694590A affects both ATP-dependent and ATP-independent luciferases, potentially influencing the Fluc reporter gene [1].</p>Fórmula:C22H19N5O4Cor e Forma:SolidPeso molecular:417.42APcK110
CAS:<p>"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."</p>Fórmula:C20H16FN3O2Cor e Forma:SolidPeso molecular:349.36Bezuclastinib
CAS:<p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>Fórmula:C19H17N5OPureza:99.55%Cor e Forma:SolidPeso molecular:331.37AC710
CAS:<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Fórmula:C31H42N6O4Pureza:99.67%Cor e Forma:SolidPeso molecular:562.7c-Kit-IN-3
CAS:<p>c-Kit-IN-3 is a selective inhibitor of c-KIT kinase with IC50s of 4 nM and 8 nM for c-Kit (wt) and c-Kit (T670I).</p>Fórmula:C26H20ClF3N2O4Pureza:99.94%Cor e Forma:SolidPeso molecular:516.9c-Kit-IN-2
CAS:<p>c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (</p>Fórmula:C25H29N9O2SPureza:98%Cor e Forma:SolidPeso molecular:519.62KBP-7018
CAS:<p>KBP-7018: potent tyrosine kinase inhibitor targeting c-KIT, RET, PDGFR with IC50s of 10, 7.6, 25nM.</p>Fórmula:C31H30N4O5Cor e Forma:SolidPeso molecular:538.59Sitravatinib malate
CAS:<p>Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5</p>Fórmula:C37H35F2N5O9SPureza:98%Cor e Forma:SolidPeso molecular:763.76Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47Tafetinib
CAS:<p>Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.</p>Fórmula:C24H29FN4O2Pureza:96.23%Cor e Forma:SolidPeso molecular:424.51Agerafenib hydrochloride
CAS:<p>Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).</p>Fórmula:C24H23ClF3N5O5Pureza:98%Cor e Forma:SolidPeso molecular:553.92Henatinib
CAS:<p>Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.</p>Fórmula:C25H29FN4O4Cor e Forma:SolidPeso molecular:468.52c-Kit-IN-8
CAS:<p>C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.</p>Fórmula:C24H26FN5O4Cor e Forma:SolidPeso molecular:467.49AMG-25
CAS:<p>AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.</p>Fórmula:C23H17N5O2Pureza:98.16%Cor e Forma:SolidPeso molecular:395.41Protein kinase inhibitor 10
CAS:<p>Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.</p>Fórmula:C14H9FN6S2Cor e Forma:SolidPeso molecular:344.39c-Kit/CD117 Protein, Human, Recombinant (His & Avi), Biotinylated
<p>c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:58.50 kDa (predicted); 87.1 kDa (reducing conditions)
