c-Kit
Os inibidores de c-Kit são compostos que bloqueiam a atividade do Receptor do Fator de Células-Tronco (c-Kit), uma tirosina quinase que desempenha um papel crucial na sobrevivência, proliferação e diferenciação celular, particularmente em células hematopoéticas. As mutações em c-Kit estão ligadas a vários tipos de câncer, incluindo tumores estromais gastrointestinais (GIST) e leucemia. Na CymitQuimica, oferecemos inibidores de c-Kit para apoiar sua pesquisa em oncologia, hematologia e biologia de células-tronco.
Foram encontrados 118 produtos para "c-Kit".
Filtrar por
Percentagem de pureza
0
100
|
0
|
50
|
90
|
95
|
100
- Preços em ordem crescente
- Preços em ordem decrescente
- Menor grau de pureza
- Maior grau de pureza
- Estimativa de entrega mais rápida
APcK110
CAS:"APcK110, a potent novel Kit inhibitor, outperforms imatinib/dasatinib in halting OCI/AML3 and HMC1.2 cell growth, also inhibiting Kit-signaling."Fórmula:C20H16FN3O2Cor e Forma:SolidPeso molecular:349.36NN-2101
NN-2101 is a human monoclonal antibody (mAb) that targets c-Kit/CD117. It is applicable in research related to retinal diseases and diabetic macular edema.c-Kit-IN-2
CAS:c-Kit-IN-2 is a c-KIT inhibitor (IC₅₀=82 nM) with anti-proliferative effects on GIST882, GIST430, GIST48 (GI₅₀=3,1,2 nM respectively).Fórmula:C25H29N9O2SPureza:98.68% - 98.95%Cor e Forma:White SolidPeso molecular:519.62Bezuclastinib
CAS:Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.Fórmula:C19H17N5OPureza:99.55%Cor e Forma:SolidPeso molecular:331.3712Tafetinib
CAS:Tafetinib (SIM-010603) is a novel potent and orally available tyrosine kinase inhibitor with anti-angiogenic and anti-tumour activity.Fórmula:C24H29FN4O2Pureza:96.23%Cor e Forma:SolidPeso molecular:424.5111Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.4739Agerafenib hydrochloride
CAS:Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).Fórmula:C24H23ClF3N5O5Pureza:98%Cor e Forma:SolidPeso molecular:553.918SIM010603
CAS:SIM010603, an oral RTK inhibitor, targets Kit, VEGFR-2, PDGFR-β, RET, FLT3 (IC50: 5.0-68.1 nmol/l), inhibits cell proliferation and angiogenesis.Fórmula:C22H25FN4O2Cor e Forma:SolidPeso molecular:396.46Henatinib
CAS:Henatinib: orally active multi-kinase inhibitor targeting VEGFR-2, c-kit, PDGFR with antitumor effects.Fórmula:C25H29FN4O4Cor e Forma:SolidPeso molecular:468.52N-desmethyl Regorafenib N-oxide
CAS:N-Desmethyl Regorafenib N-oxide, an active metabolite of the multi-kinase inhibitor regorafenib, originates through the action of the cytochrome P450 (CYP) isoform CYP3A4. This compound demonstrates efficacy in vitro by inhibiting key enzymes such as VEGFR2, Tie2, c-Kit, and B-RAF, and it exhibits tumor growth inhibition in HT-29 and MDA-MB-231 mouse xenograft models at a dosage of 1 mg/kg.Fórmula:C20H13ClF4N4O4Cor e Forma:SolidPeso molecular:484.79Labuxtinib
CAS:Labutinib is a selective inhibitor of the c-kit tyrosine kinase [1].Fórmula:C20H16FN5O2Pureza:99.95%Cor e Forma:SolidPeso molecular:377.37c-Kit-IN-7
CAS:c-Kit-IN-7 (compound 104) serves as an effective inhibitor of c-Kit, exhibiting an IC50 of 10 nM or less. It plays a crucial role in cancer research.Fórmula:C27H32FN7O3Cor e Forma:SolidPeso molecular:521.59AMG-25
CAS:AMG-25 (c-Kit-IN-5-1) is a c-Kit inhibitor that inhibits c-Kit, KDR, p38, Lck, and Src, and can be used for the study of mast cell-associated fibrotic diseases.Fórmula:C23H17N5O2Pureza:98.16%Cor e Forma:Yellow SolidPeso molecular:395.4134c-Kit-IN-8
CAS:C-Kit-IN-8 (Compound 53) acts as an inhibitor of c-Kit kinase, hampering uKIT kinase activity with an IC50 greater than 1 μM. Additionally, it inhibits the proliferation of both wild-type and mutant GIST430 and BaF3 cancer cells, exhibiting an IC50 greater than 0.1 μM.Fórmula:C24H26FN5O4Cor e Forma:SolidPeso molecular:467.49Henatinib maleate
CAS:Henatinib maleate is an orally active small-molecule multi-kinase inhibitor. It inhibits the activity of VEGFR-2, c-kit, and PDGFR with IC50 values of 0.6 nM, 3.3 nM, and 41.5 nM, respectively. Henatinib maleate significantly suppresses VEGFR-2 phosphorylation and its downstream signaling pathways, and it possesses extensive antitumor activity.Fórmula:C29H33FN4O8Peso molecular:584.6Protein kinase inhibitor 10
CAS:Protein kinase inhibitor 10 is a protein kinase inhibitor with IC50 values of 28.9 μM, 13.6 μM, and 2.41 μM for TAM receptors, FAK, and KIT, respectively. It can inhibit abnormal and excessive cell proliferation, showing potential for research in the field of cancer treatment.Fórmula:C14H9FN6S2Cor e Forma:SolidPeso molecular:344.39Anti-C-Kit Antibody (9Y519)
Anti-C-Kit Antibody (9Y519) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (9Y519) can be used in ELISA.Cor e Forma:Odour LiquidAnti-C-Kit Antibody (7P530)
Anti-C-Kit Antibody (7P530) is a Mouse antibody targeting C-Kit. Anti-C-Kit Antibody (7P530) can be used in FCM.Cor e Forma:Odour Liquid
