Ubiquitinação
Os inibidores de ubiquitinação são compostos que interferem no processo de ubiquitinação, onde as proteínas são marcadas com moléculas de ubiquitina para degradação pelo proteassoma. Esses inibidores são críticos para o estudo da renovação de proteínas, transdução de sinais e regulação de vários processos celulares. A ubiquitinação desempenha um papel fundamental em muitas doenças, incluindo câncer, distúrbios neurodegenerativos e disfunções do sistema imunológico. Ao modular a ubiquitinação, esses inibidores podem fornecer insights sobre os mecanismos das doenças e abrir novas vias para intervenções terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de ubiquitinação de alta qualidade para apoiar sua pesquisa em biologia celular, proteômica e descoberta de medicamentos.
Subcategorias de "Ubiquitinação"
Foram encontrados 107 produtos de "Ubiquitinação"
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USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Fórmula:C26H28FN3O4SPureza:99.85%Cor e Forma:SolidPeso molecular:497.58Cbl-b-IN-13
CAS:<p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>Fórmula:C29H30F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:537.58Cbl-b-IN-6
CAS:<p>Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (</p>Fórmula:C30H32F5N5OPureza:98%Cor e Forma:SolidPeso molecular:573.6Cbl-b-IN-10
CAS:<p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>Fórmula:C31H37F3N6OPureza:98%Cor e Forma:SolidPeso molecular:566.66Cbl-b-IN-9
CAS:<p>Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal</p>Fórmula:C30H33F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:566.62Cbl-b-IN-12
CAS:<p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>Fórmula:C28H29F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:538.56Cbl-b-IN-7
CAS:<p>Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s</p>Fórmula:C29H31F4N5O2Pureza:98%Cor e Forma:SolidPeso molecular:557.58Skp2 inhibitor 2
CAS:<p>Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.</p>Fórmula:C27H32N4OPureza:98%Cor e Forma:SolidPeso molecular:428.57Cbl-b-IN-8
CAS:<p>Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5</p>Fórmula:C35H44F3N7O3Pureza:98%Cor e Forma:SolidPeso molecular:667.76Cbl-b-IN-11
CAS:<p>Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of</p>Fórmula:C31H35F5N6OPureza:98%Cor e Forma:SolidPeso molecular:602.64USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Fórmula:C23H24ClN3O3Pureza:99.82%Cor e Forma:SolidPeso molecular:425.91LDN-91946
CAS:<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Fórmula:C15H10N2O4SPureza:97.12%Cor e Forma:SolidPeso molecular:314.32UPCDC30766
CAS:<p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>Fórmula:C30H32F2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:594.68FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Fórmula:C24H23F4N7O3Pureza:98%Cor e Forma:SolidPeso molecular:533.48PYZD-4409
CAS:<p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>Fórmula:C14H7ClFN3O5Pureza:99.71%Cor e Forma:SolidPeso molecular:351.67CC0651
CAS:<p>CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).</p>Fórmula:C20H21Cl2NO6Pureza:99.03%Cor e Forma:SolidPeso molecular:442.29UC-764864
CAS:<p>UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in</p>Fórmula:C19H18N2OSPureza:99.3%Cor e Forma:SolidPeso molecular:322.42IMP-1710
CAS:<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Fórmula:C23H19N5OPureza:99.3%Cor e Forma:SolidPeso molecular:381.43BC-1293
CAS:<p>BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.</p>Fórmula:C26H28N4O4SPureza:98.40%Cor e Forma:SolidPeso molecular:492.59PRC1-IN-1
CAS:<p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>Fórmula:C24H19ClFN3O2Cor e Forma:SolidPeso molecular:435.878
