Proteassoma
Os inibidores de proteassoma são compostos que inibem o proteassoma, um grande complexo proteico responsável pela degradação de proteínas indesejadas ou danificadas dentro da célula. A inibição do proteassoma leva ao acúmulo de proteínas, o que pode induzir a parada do ciclo celular e a apoptose, especialmente em células de rápida divisão, como as células cancerosas. Os inibidores de proteassoma são cruciais na pesquisa e terapia do câncer, especialmente no tratamento do mieloma múltiplo e outras malignidades hematológicas. Na CymitQuimica, oferecemos inibidores de proteassoma para apoiar sua pesquisa em oncologia, biologia celular e desenvolvimento de fármacos.
Foram encontrados 72 produtos para "Proteassoma".
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Gabexate mesylate
CAS:Gabexate mesylate (FOY) inhibits thrombin, plasmin, kallikrein; used for pancreatitis, DIC, hemodialysis anticoagulant.Fórmula:C17H27N3O7SPureza:99.2% - 99.64%Cor e Forma:White CrystalPeso molecular:417.48UT-34
CAS:UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wildFórmula:C15H12F4N4O2Pureza:98.12%Cor e Forma:SolidPeso molecular:356.275RAMB4
CAS:RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.Fórmula:C19H13Cl4NOPureza:98.89% - 99.38%Cor e Forma:Yellow SolidPeso molecular:413.12RA190
CAS:RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.Fórmula:C28H23Cl5N2O2Pureza:97.7%Cor e Forma:SolidPeso molecular:596.759Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.44% - 99.98%Cor e Forma:SolidPeso molecular:429.852Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Fórmula:C34H63N5O9Pureza:96.74% - 99.94%Cor e Forma:SolidPeso molecular:685.8921ML604440
CAS:ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.Fórmula:C17H24BF3N2O4Pureza:97.06%Cor e Forma:SolidPeso molecular:388.19Protease Inhibitor Library
A unique collection of xnum protease and proteasome inhibitors for research in chemical genomics, and drug screening;Cor e Forma:Odour SolidPhepropeptin B
CAS:Phepropeptin B is a secondary metabolite derived from microorganisms, functioning as a proteasome (proteasome) inhibitor with an IC50 value of 11 μg/mL.Fórmula:C40H56N6O6Cor e Forma:SolidPeso molecular:716.91Phepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Fórmula:C38H60N6O6Cor e Forma:SolidPeso molecular:696.92Z-Leu-Leu-Tyr-COCHO
CAS:Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].Fórmula:C30H39N3O7Pureza:98%Cor e Forma:SolidPeso molecular:553.65Dazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Cor e Forma:SolidPeso molecular:395.3837Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Fórmula:C48H56N6O10SCor e Forma:SolidPeso molecular:909.06Iso-VQA-ACC acetate
Iso-VQA-ACC acetate serves as a substrate for the constitutive proteasome.Cor e Forma:Odour SolidBortezomib analog
Bortezomibanalog (Compound 13) is an analog of Bortezomib, functioning as an active control ligand for the 20S proteasome subunit β5.Cor e Forma:Odour SolidLXE408 fumarate
LXE408 fumarate: orally available, selective kinetoplastid proteasome inhibitor with IC50/EC50 of 0.04 μM for L. donovani; potentially aids in VL research.Fórmula:C27H22FN7O6Pureza:99.89%Cor e Forma:SolidPeso molecular:559.51Ac-Nle-Pro-Nle-Asp-AMC
CAS:Ac-Nle-Pro-Nle-Asp-AMC: 26S proteasome substrate for caspase-like activity analysis.Fórmula:C33H45N5O9Peso molecular:655.7385Z-Gly-Pro-Phe-Leu-CHO
CAS:Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) ofFórmula:C30H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:550.65Suc-Leu-Leu-Val-Tyr-AMC
CAS:Suc-Leu-Leu-Val-Tyr-AMC is a fluorogenic tetrapeptide substrate for 20S proteasome and chymotrypsin-like proteases, used in drug screening.Fórmula:C40H53N5O10Pureza:98%Cor e Forma:SolidPeso molecular:763.8763Phepropeptin A
CAS:Phepropeptin A is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 21 μg/mL.Fórmula:C37H58N6O6Cor e Forma:SolidPeso molecular:682.89
