Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1507 produtos para "Autofagia".
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Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidTigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Fórmula:C30H43N5O11SPureza:98%Cor e Forma:SolidPeso molecular:681.75Autocamtide 2, amide
Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.Fórmula:C65H119N23O19Pureza:98%Cor e Forma:SolidPeso molecular:1526.79(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Fórmula:C16H18F6N5O5PCor e Forma:SolidPeso molecular:505.314Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Fórmula:C20H24ClNO4Cor e Forma:SolidPeso molecular:377.86Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Fórmula:C43H52N6O19P3Cor e Forma:SolidPeso molecular:1049.826-Mercaptopurine-13C2,15N
CAS:6-Mercaptopurine-13C2,15N is a 6-Mercaptopurine (T0010) labeled with 13C and 15N. This compound is a purine analog that acts as an antagonist to endogenous purines and is widely used for its anti-leukemic and immunosuppressive properties.Fórmula:C5H4N4SCor e Forma:SolidPeso molecular:155.16Obeticholic acid-D5
CAS:Obeticholic acid-D5 is the deuterated form of Obeticholic acid. Obeticholic acid (T1789) (INT-747) acts as a potent, selective, and orally active FXR agonist with an EC50 of 99 nM, exhibiting both anticholeretic and anti-inflammatory properties. Additionally, Obeticholic acid (T1789) can induce autophagy (autophagy).Fórmula:C26H44O4Cor e Forma:SolidPeso molecular:425.66RK-682 (calcium salt)
CAS:RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Fórmula:C42H74CaO10Cor e Forma:SolidPeso molecular:779.122Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83OsMo
OsMo is a lysosomal-targeting hNEU1 inhibitor utilized in the study of myocardial injury.Cor e Forma:Odour Solid(R)-Hydroxychloroquine phosphate
CAS:(R)-Hydroxychloroquine ((R)-HCQ) phosphate is an isomer of Hydroxychloroquine. It inhibits insulin-metabolizing enzymes in the cytosolic fraction of liver homogenates in both healthy and diabetic rats.Fórmula:C18H28ClN3O5SCor e Forma:SolidPeso molecular:433.95Cisatracurium besylate
CAS:Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.Fórmula:C53H72N2O12·2C6H5O3SPureza:97.89% - 99.85%Cor e Forma:SolidPeso molecular:1243.48Ref: TM-T1459
10mg44,00€1mL*10mM (DMSO)57,00€25mg66,00€50mg105,00€100mg170,00€200mg250,00€500mg427,00€Binimetinib-13C-D3
Binimetinib-13C-d3 (MEK162) is an isotopically labelled compound of Binimetinib.Binimetinib (ARRY-162) is a selective MEK1/2 inhibitor melanoma.Fórmula:C17H15BrF2N4O3Cor e Forma:SolidPeso molecular:445.24LG100268
CAS:LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.Fórmula:C24H29NO2Pureza:99.83%Cor e Forma:SolidPeso molecular:363.49TRAF6 peptide TFA
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.Fórmula:C145H238N34O44·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:3161.64 (free acid)Rosuvastatin-D3 Sodium
CAS:Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).Fórmula:C22H24D3FN3NaO6SPureza:98%Cor e Forma:SolidPeso molecular:506.54KN-93 hydrochloride
CAS:KN-93 hydrochloride is a reversible, competitive CaMKII inhibitor inducing reversible G1 arrest, supporting cell cycle and signaling pathway studies.Fórmula:C26H30Cl2N2O4SPureza:99.99%Cor e Forma:White SolidPeso molecular:537.5Loperamide hydrochloride (Standard)
CAS:Loperamide hydrochloride (Standard) is the standard substance of Loperamide hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.Fórmula:C29H34Cl2N2O2Peso molecular:513.50Wortmannin (Standard)
CAS:Wortmannin (Standard) is the standard substance of Wortmannin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.Fórmula:C23H24O8Peso molecular:428.43Nitrendipine (Standard)
CAS:Nitrendipine (Standard) is the standard substance of Nitrendipine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.Fórmula:C18H20N2O6Peso molecular:360.36Imiquimod (Standard)
CAS:Imiquimod (Standard) is the standard substance of Imiquimod, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Imiquimod (R 837) is an immune response modifier and a toll-like receptor 7 (TLR7) agonist with antiviral and antitumor effects. It is used in the study of external genital warts, perianal warts, cancer, and COVID-19, and is commonly employed to induce psoriasis models.Fórmula:C14H16N4Peso molecular:240.30Ezetimibe-D4
CAS:Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activationFórmula:C24H21F2NO3Pureza:98%Cor e Forma:SolidPeso molecular:413.45Rapalink-1
CAS:Rapalink-1 is an mTOR inhibitor that inhibits the mTORC1-4E-BP1 pathway in mice.Fórmula:C91H138N12O24Pureza:98%Cor e Forma:White ViscousPeso molecular:1784.14BI-9627 hydrochloride
CAS:BI-9627 hydrochloride is a potent NHE1 inhibitor (IC₅₀ 6 nM, 31 nM), highly selective over NHE2, inactive on NHE3, regulating pH and autophagy.Fórmula:C16H20ClF3N4O2Pureza:99.91%Cor e Forma:White SolidPeso molecular:392.8Pemetrexed disodium heptahydrate
CAS:Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits TS, DHFR and GARFT, inhibits precursor purine and pyrimidine nucleotides.Fórmula:C20H33N5Na2O13Pureza:99.78%Cor e Forma:White SolidPeso molecular:597.49Erlotinib-D6 hydrochloride
CAS:Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.Fórmula:C22H24ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:435.93PS372424 hydrochloride
CAS:PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Fórmula:C33H45ClN6O4Pureza:95.03%Cor e Forma:Transparent ViscousPeso molecular:625.2Ponatinib-D8
CAS:Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).Fórmula:C29H27F3N6OPureza:98%Cor e Forma:SolidPeso molecular:540.61Guanidine hydrochloride (Standard)
CAS:Guanidine hydrochloride (Standard) is the standard substance of Guanidine hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.Fórmula:CH6ClN3Cor e Forma:SolidPeso molecular:95.53Clotrimazole (Standard)
CAS:Clotrimazole (Standard) is the standard substance of Clotrimazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.Fórmula:C22H17ClN2Cor e Forma:SolidPeso molecular:344.84Colistin sulfate (Standard)
CAS:Colistin sulfate (Standard) is the standard substance of Colistin sulfate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Colistin sulfate (Colistin sulfate (1066-17-7 free base)) is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.Cor e Forma:SolidAtorvastatin hemicalcium salt (Standard)
CAS:Atorvastatin hemicalcium salt (Standard) is the standard substance of Atorvastatin hemicalcium salt, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol.Fórmula:C33H34FN2O5CaCor e Forma:SolidPeso molecular:577.67Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Cor e Forma:Odour LiquidBergapten (Standard)
CAS:Bergapten (Standard) is the standard substance of Bergapten, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.Fórmula:C12H8O4Cor e Forma:SolidPeso molecular:216.19Tetrahydrocurcumin-D6
CAS:Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.Fórmula:C21H24O6Pureza:98%Cor e Forma:SolidPeso molecular:378.45Idelalisib-D5
CAS:Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.Fórmula:C22H18FN7OPureza:98%Cor e Forma:SolidPeso molecular:420.45Ladarixin
CAS:Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis.Fórmula:C11H12F3NO6S2Pureza:99.36%Cor e Forma:White SolidPeso molecular:375.34ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.Fórmula:C27H28F2N6O3Pureza:98.31%Cor e Forma:SolidPeso molecular:522.55Olaparib-D5
CAS:Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP.Fórmula:C24H23FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:439.49Levomepromazine
CAS:Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.Fórmula:C19H24N2OSPureza:99.15%Cor e Forma:White SolidPeso molecular:328.47Curcumin-D6
CAS:Curcumin-D6 is deuterium-labeled curcumin (Turmeric yellow). Curcumin (T1516) (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-angiogenic activities. Curcumin (T1516) is an inhibitor of p300 histone acetyltransferases (HATs), and also shows inhibitory effects on NF-κB and MAPKs.Fórmula:C21H20O6Pureza:98%Cor e Forma:SolidPeso molecular:374.422ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Fórmula:C104H178N26O25S2Cor e Forma:SolidPeso molecular:2256.82Loperamide-D6 hydrochloride
CAS:Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.Fórmula:C29H34Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:519.54CXCR2 antagonist 8
CAS:CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Fórmula:C14H13N3O5Cor e Forma:Yellow SolidPeso molecular:303.27THZ-P1-2
CAS:THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.Fórmula:C31H29N7O2Pureza:99.79%Cor e Forma:Yellow SolidPeso molecular:531.61Ref: TM-T39459
1mg71,00€2mg92,00€5mg152,00€1mL*10mM (DMSO)172,00€10mg205,00€25mg331,00€50mg467,00€100mg655,00€200mg884,00€Br-DAPI
CAS:IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.Fórmula:C16H14BrN5Pureza:100%Cor e Forma:SolidPeso molecular:356.22(R)-BPO-27
CAS:(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.Fórmula:C26H18BrN3O6Pureza:99.1%Cor e Forma:SolidPeso molecular:548.34Desethyl chloroquine diphosphate
CAS:Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.Fórmula:C16H28ClN3O8P2Pureza:99.72%Cor e Forma:SolidPeso molecular:487.81Regorafenib-D3
CAS:Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.Fórmula:C21H15ClF4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:485.83
