Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1494 produtos de "Autofagia"
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Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Fórmula:C39H59N13O8S2Cor e Forma:SolidPeso molecular:902.1Microcolin H
CAS:Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].Fórmula:C38H63N5O9Cor e Forma:SolidPeso molecular:733.93Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFórmula:C32H38Cl3N7Cor e Forma:SolidPeso molecular:627.05cGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Fórmula:C31H51ClN7O14PSCor e Forma:SolidPeso molecular:844.27Salinomycin sodium salt
CAS:Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.Fórmula:C42H69NaO11Pureza:98.76% - 99.11%Cor e Forma:White Or Light Yellow Crystalline Powder With Special SmelPeso molecular:772.98Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidPBA-1105b
CAS:PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.Fórmula:C47H64N2O10Cor e Forma:SolidPeso molecular:817.02PTX80
CAS:PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.Fórmula:C26H26N4O3SCor e Forma:SolidPeso molecular:474.58Sulfadiazine
CAS:Sulfadiazine, a short-acting sulfonamide, blocks bacterial folic acid synthesis; used with pyrimethamine to treat toxoplasmosis in AIDS, newborns.Fórmula:C10H10N4O2SPureza:99.32%Cor e Forma:White To Slightly Yellow Crystalline PowderPeso molecular:250.28ABX-IL8
ABX-IL8 is a humanized antibody targeting IL-8, capable of interfering with tube formation in human umbilical vein endothelial cells.Pureza:>95%Cor e Forma:LiquidPeso molecular:143.94 kDaNictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.
Fórmula:C123H193N45O28Cor e Forma:SolidPeso molecular:2750.13MRT 67307 dihydrochloride
CAS:MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.
Fórmula:C26H38Cl2N6O2Pureza:99.75%Cor e Forma:SoildPeso molecular:537.53Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Fórmula:C27H45NO3Cor e Forma:SolidPeso molecular:431.65CXM102
CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.Fórmula:C28H27NO3Cor e Forma:SolidPeso molecular:425.52Tigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Fórmula:C30H43N5O11SPureza:98%Cor e Forma:SolidPeso molecular:681.75Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Fórmula:C38H42Cl2N6O2Cor e Forma:SolidPeso molecular:685.69Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Fórmula:C53H66N4O16S4Cor e Forma:SolidPeso molecular:1143.37Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Fórmula:C23H26ClI2NO3Pureza:98%Cor e Forma:SolidPeso molecular:653.72NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Fórmula:C56H68ClN9O5S2Cor e Forma:SolidPeso molecular:1046.78SGLT2-IN-2
SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2 and significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activities. It provides protection against myocardial cell damage induced by glucose-free DMEM. Additionally, SGLT2-IN-2 markedly improves cardiac function in TAC-induced heart failure (HF) mice, suppressing myocardial cell hypertrophy and collagen deposition. It reduces myocardial tissue damage and boosts autophagy in damaged myocardial cells, increasing the survival rate of HF mice.Cor e Forma:Odour Solid
