Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1489 produtos de "Autofagia"
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Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Cor e Forma:Odour SolidPBA-1105b
CAS:PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.Fórmula:C47H64N2O10Cor e Forma:SolidPeso molecular:817.02Cabergoline
CAS:<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Fórmula:C26H37N5O2Pureza:97.69% - 99.86%Cor e Forma:White Crystalline SolidPeso molecular:451.6Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Fórmula:C20H24ClNO4Cor e Forma:SolidPeso molecular:377.86MRL828
MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.Fórmula:C46H51FN14O5SCor e Forma:SolidPeso molecular:930.38716Tigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Fórmula:C30H43N5O11SPureza:98%Cor e Forma:SolidPeso molecular:681.75Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Fórmula:C53H66N4O16S4Cor e Forma:SolidPeso molecular:1143.37Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Fórmula:C27H45NO3Cor e Forma:SolidPeso molecular:431.65LC3B recruiter 2
CAS:LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.Fórmula:C10H9ClN2O2Cor e Forma:SolidPeso molecular:224.644Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Fórmula:C44H36Cl5FeN8Cor e Forma:SolidPeso molecular:909.92Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Fórmula:C38H42Cl2N6O2Cor e Forma:SolidPeso molecular:685.69NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Fórmula:C56H68ClN9O5S2Cor e Forma:SolidPeso molecular:1046.78Autophagy agonist-1
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.Fórmula:C33H41N3O5Cor e Forma:SolidPeso molecular:559.7ATRA-biotin
CAS:ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues.Fórmula:C36H55N3O4SCor e Forma:SolidPeso molecular:625.91MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Fórmula:C26H38Cl2N6O2Pureza:99.75%Cor e Forma:SoildPeso molecular:537.53IMCTA-C14 TFA
IMCTA-C14, a detergent and derivative of the microbial metabolite 4-trehalosamine, exhibits a critical micelle concentration (CMC) of 0.11 mM and a hydrophilic-Fórmula:C26H51NO10·CF3COOHCor e Forma:SolidPeso molecular:651.71Lipophagy inducer 1
Lipophagy inducer 1 (Compound 2726.007) is an agent that induces lipophagy. It primarily acts to reduce lipid droplet accumulation and prevent podocyte death. The compound operates by activating lipophagy and regulating the LXR signaling pathway. Lipophagy inducer 1 is useful for research into diabetic kidney disease (DKD) and other disorders related to lipid metabolism.Cor e Forma:Odour SolidG-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Fórmula:C27H31IN2O3Cor e Forma:SolidPeso molecular:558.45Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Fórmula:C43H52N6O19P3Cor e Forma:SolidPeso molecular:1049.82
