Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1489 produtos de "Autofagia"
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MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Fórmula:C26H38Cl2N6O2Pureza:99.75%Cor e Forma:SoildPeso molecular:537.53Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Fórmula:C53H66N4O16S4Cor e Forma:SolidPeso molecular:1143.37Atorvastatin Sodium
CAS:Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors onFórmula:C33H34FN2NaO5Pureza:99.88% - >99.99%Cor e Forma:SolidPeso molecular:580.63Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Fórmula:C8H15NaO2Pureza:98% - 99.78%Cor e Forma:White PowderPeso molecular:166.2Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Fórmula:C20H24ClNO4Cor e Forma:SolidPeso molecular:377.86Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Fórmula:C27H45NO3Cor e Forma:SolidPeso molecular:431.65Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Fórmula:C115H145ClN18O31S2Zn2Cor e Forma:SolidPeso molecular:2505.83PHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Fórmula:C51H50F6N4O7Cor e Forma:SolidPeso molecular:944.96E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFórmula:C108H178N34O28Pureza:98%Cor e Forma:SolidPeso molecular:2400.78Peptide 78
CAS:Peptide 78 is identical to peptide 74 except that serine replaces cysteine. It does not inhibit 72-kDa type IV collagenase.Fórmula:C62H107N23O21SPureza:98%Cor e Forma:SolidPeso molecular:1542.74SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFórmula:C356H578N106O93S4Pureza:98%Cor e Forma:SolidPeso molecular:7959.34Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Fórmula:C23H26ClI2NO3Pureza:98%Cor e Forma:SolidPeso molecular:653.72ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Fórmula:C94H82N4O2S4Pureza:98%Cor e Forma:SolidPeso molecular:1427.96Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Fórmula:C27H48F3N9O7Cor e Forma:SolidPeso molecular:667.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Fórmula:C27H31IN2O3Cor e Forma:SolidPeso molecular:558.45TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Fórmula:C32H55N3O10SCor e Forma:SolidPeso molecular:673.86Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Fórmula:C43H52N6O19P3Cor e Forma:SolidPeso molecular:1049.82VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Fórmula:C25H31BrINPureza:99.82%Cor e Forma:SolidPeso molecular:552.334-Amino-D-phenylalanine
CAS:4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.Fórmula:C9H12N2O2Cor e Forma:SolidPeso molecular:180.2Vimnerixin
CAS:Vimnerixin (AZD4721) is an orally administered CXCR2 antagonist for inflammation studies.Fórmula:C19H25FN4O5S2Cor e Forma:SolidPeso molecular:472.55
