Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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IT1t dihydrochloride
CAS:<p>IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.</p>Fórmula:C21H36Cl2N4S2Pureza:99.91%Cor e Forma:SolidPeso molecular:479.57Cysmethynil
CAS:<p>Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.</p>Fórmula:C25H32N2OPureza:99%Cor e Forma:SolidPeso molecular:376.53Laduviglusib trihydrochloride
CAS:<p>Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.</p>Fórmula:C22H20Cl5N8Pureza:99.34%Cor e Forma:SolidPeso molecular:573.71Elubrixin
CAS:<p>Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).</p>Fórmula:C17H17Cl2FN4O4SPureza:98.65% - 99.78%Cor e Forma:SolidPeso molecular:463.31Dactolisib Tosylate
CAS:<p>Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.</p>Fórmula:C37H31N5O4SPureza:99.91%Cor e Forma:SolidPeso molecular:641.74XRK3F2
CAS:<p>XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.</p>Fórmula:C23H24ClF2NO3Pureza:98.75% - 98.91%Cor e Forma:SolidPeso molecular:435.89Tin-protoporphyrin IX dichloride
CAS:<p>Tin-protoporphyrin IX inhibits HO-1, enhancing chemo efficacy in mouse PDAC.</p>Fórmula:C34H32Cl2N4O4SnPureza:98%Cor e Forma:SolidPeso molecular:750.26CHIR-99021 HCl
CAS:<p>CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.</p>Fórmula:C22H19Cl3N8Pureza:98.07% - 98.14%Cor e Forma:SolidPeso molecular:501.8Cytarabine hydrochloride
CAS:<p>Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.</p>Fórmula:C9H14ClN3O5Pureza:98.46%Cor e Forma:White PowderPeso molecular:279.68ITX5061
CAS:<p>ITX5061 is a type II inhibitor of p38 MAPK and scavenger receptor B1 (SRB1) antagonist for the study of hepatitis C virus infection.</p>Fórmula:C30H38ClN3O7SPureza:98.35%Cor e Forma:SolidPeso molecular:620.16LRRK2-IN-7
CAS:<p>LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.</p>Fórmula:C24H26N6OPureza:99.26%Cor e Forma:SolidPeso molecular:414.5AZD8797
CAS:<p>AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.</p>Fórmula:C19H25N5OS2Pureza:98.73% - 99.68%Cor e Forma:SolidPeso molecular:403.56Mavorixafor
CAS:<p>Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.</p>Fórmula:C21H27N5Pureza:98.56%Cor e Forma:SolidPeso molecular:349.47AZD8309
CAS:<p>AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.</p>Fórmula:C15H14F2N4O2S2Pureza:98.35% - 99.67%Cor e Forma:SolidPeso molecular:384.42FMK 9a
CAS:<p>FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.</p>Fórmula:C23H21FN2O3Pureza:98.97%Cor e Forma:SolidPeso molecular:392.42MTK458
CAS:<p>MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.</p>Fórmula:C17H15F3N4Pureza:98.36%Cor e Forma:SolidPeso molecular:332.32Cosalane
CAS:<p>Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.</p>Fórmula:C45H60Cl2O6Pureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:767.86DCAP
CAS:<p>DCAP, a broad-spectrum antibiotic, disrupts the membranes of both Gram-positive and Gram-negative bacteria. Additionally, it inhibits late-stage autophagy by blocking autophagolysosome maturation and interrupting autophagic flux [1].</p>Fórmula:C19H22Cl2N2O4Cor e Forma:SolidPeso molecular:413.3XIE62-1004
CAS:<p>XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.</p>Fórmula:C23H25NO3·HClCor e Forma:SolidPeso molecular:399.91p38-α MAPK-IN-1
CAS:<p>p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.</p>Fórmula:C27H35N5O3Pureza:99.93%Cor e Forma:SolidPeso molecular:477.6
