Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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6CEPN
CAS:<p>6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.</p>Fórmula:C23H18O5Cor e Forma:SolidPeso molecular:374.39CXCR4 antagonist 6
CAS:<p>CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.</p>Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Cor e Forma:SolidPeso molecular:687.7AEW541 HCl
CAS:<p>AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.</p>Fórmula:C27H31Cl2N5OCor e Forma:SolidPeso molecular:512.47Antitumor agent-82
<p>Antitumor agent-82: potent, anti-proliferative, induces autophagy via ATG5/ATG7.</p>Fórmula:C32H42N6Cor e Forma:SolidPeso molecular:510.72KN-93 Phosphate
CAS:<p>KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.</p>Fórmula:C26H32ClN2O8PSPureza:99.58% - 99.93%Cor e Forma:SolidPeso molecular:599.03RK-682
CAS:<p>RK-682 is a natural selective inhibitor of protein tyrosine phosphatases (PTPases).</p>Fórmula:C21H36O5Cor e Forma:SolidPeso molecular:368.51AGN-195183
CAS:<p>AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.</p>Fórmula:C22H22ClF2NO4Cor e Forma:SolidPeso molecular:437.86Di-N-desethyl amiodarone hydrochloride
CAS:<p>Di-N-desethyl Amiodarone hydrochloride, a metabolite of Amiodarone, functions as a potent inhibitor of the respiratory chain [1].</p>Fórmula:C21H22ClI2NO3Pureza:98%Cor e Forma:SolidPeso molecular:625.67LY2955303
CAS:<p>LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).</p>Fórmula:C36H42N4O3Pureza:98.56% - 99.85%Cor e Forma:SolidPeso molecular:578.74E6130
CAS:<p>E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.</p>Fórmula:C28H37ClF3N3O3Cor e Forma:SolidPeso molecular:556.06(3R,5R)-Rosuvastatin
CAS:<p>(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Fórmula:C22H28FN3O6SPureza:98%Cor e Forma:SolidPeso molecular:481.544E2RCat
CAS:<p>4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expression</p>Fórmula:C22H14ClNO4S2Pureza:98.44%Cor e Forma:SolidPeso molecular:455.93Beclin1-ATG14L interaction inhibitor 1
CAS:<p>Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.</p>Fórmula:C23H24N4O5SPureza:98%Cor e Forma:SolidPeso molecular:468.53INT-767
CAS:<p>INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial function</p>Fórmula:C25H43NaO6SPureza:98%Cor e Forma:SolidPeso molecular:494.66CXCR4 antagonist 7
CAS:<p>Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.</p>Fórmula:C15H17N5O3Cor e Forma:SolidPeso molecular:315.33Ruxolitinib sulfate
CAS:<p>Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.</p>Fórmula:C17H20N6O4SCor e Forma:SolidPeso molecular:404.45Gly-β-MCA
CAS:<p>Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.</p>Fórmula:C26H43NO6Pureza:≥98.0%Cor e Forma:SolidPeso molecular:465.62Butylate
CAS:<p>Butylate is a herbicide of thiocarbamate.</p>Fórmula:C11H23NOSCor e Forma:Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoisturePeso molecular:217.37CXCR2-IN-2
CAS:<p>CXCR2-IN-2: A selective, brain-penetrant, oral CXCR2 inhibitor (IC50: 5.2 nM/1 nM). ~730x selectivity vs CXCR1, >1900x vs other chemokine receptors.</p>Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9
