Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
(R,R)-CXCR2-IN-2
CAS:<p>'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'</p>Fórmula:C18H23ClN2O5SCor e Forma:SolidPeso molecular:414.9TIQ-15
CAS:<p>TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.</p>Fórmula:C23H32N4Pureza:98%Cor e Forma:SolidPeso molecular:364.53p38 MAPK-IN-1
CAS:<p>p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.</p>Fórmula:C21H14F2N2OPureza:98%Cor e Forma:SolidPeso molecular:348.35CXCR2 antagonist 3
CAS:<p>Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.</p>Fórmula:C17H15FN2O4SCor e Forma:SolidPeso molecular:362.38(±)-AMG 487
<p>AMG 487 is an effective and selective antagonist of chemokine receptor 3.</p>Fórmula:C32H28F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:603.59BPO-27 racemate
CAS:<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Cor e Forma:SolidPeso molecular:548.34Ladarixin Sodium
CAS:<p>Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.</p>Fórmula:C11H12F3NNaO6S2Cor e Forma:SolidPeso molecular:398.32SR10067
CAS:<p>SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.</p>Fórmula:C31H31NO3Pureza:99.57%Cor e Forma:SolidPeso molecular:465.58Acitretin sodium
CAS:<p>Acitretin sodium is a second-generation, systemic retinoid. It is also has been used in the treatment of psoriasis.</p>Fórmula:C21H26NaO3Pureza:98%Cor e Forma:SolidPeso molecular:349.42AGN 194078
CAS:<p>AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).</p>Fórmula:C22H23F2NO4Cor e Forma:SolidPeso molecular:403.42Pentixafor
CAS:<p>Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission</p>Fórmula:C60H80N14O14Pureza:98%Cor e Forma:SolidPeso molecular:1221.36Cisd2 agonist 1
CAS:<p>Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).</p>Fórmula:C14H13FN2O3SPureza:99.06%Cor e Forma:SolidPeso molecular:308.33AGN 194310
CAS:<p>AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].</p>Fórmula:C28H24O2SCor e Forma:SolidPeso molecular:424.55ATG12-ATG3 inhibitor 1
CAS:<p>ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].</p>Fórmula:C18H17NO3SCor e Forma:SolidPeso molecular:327.4EACC
CAS:<p>EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.</p>Fórmula:C13H11N3O6S2Pureza:99.8%Cor e Forma:SolidPeso molecular:369.37NUCC-390 dihydrochloride (1060524-97-1 free base)
<p>NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.</p>Fórmula:C23H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:468.46SLLN-15
CAS:<p>SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.</p>Fórmula:C19H23N7Se2Pureza:98%Cor e Forma:SolidPeso molecular:507.35CXCR2 antagonist 2
CAS:<p>CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.</p>Fórmula:C17H17FN2O4SCor e Forma:SolidPeso molecular:364.39SAFit2
CAS:<p>SAFit2 is a highly potent and selective inhibitor of fk506 binding protein 51 (FKBP51).Cost-effective and quality-assured</p>Fórmula:C46H62N2O10Pureza:98.16% - >99.99%Cor e Forma:SolidPeso molecular:802.99PHY34
CAS:<p>PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.</p>Fórmula:C30H30O12Pureza:98.71%Cor e Forma:SolidPeso molecular:582.55
