DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 110 produtos para "DUB".
Filtrar por
Percentagem de pureza
0
100
|
0
|
50
|
90
|
95
|
100
- Preços em ordem crescente
- Preços em ordem decrescente
- Menor grau de pureza
- Maior grau de pureza
- Estimativa de entrega mais rápida
T20-M
T20-M is a precursor peptide with strong binding affinity for UBE2C.Fórmula:C87H140N22O26SCor e Forma:SolidPeso molecular:1942.24USP7-IN-10 hydrochloride
USP7-IN-10 hydrochloride, also known as compound 1, is a potent inhibitor of the enzyme ubiquitin-specific protease 7 (USP7), exhibiting an IC50 value of 13.39Fórmula:C26H30Cl2N4O3SCor e Forma:SolidPeso molecular:549.51Ubiquitination Compound Library
A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；Cor e Forma:Odour SolidGK16S
GK16S, a UCHL1 chemogenomic probe, serves as a complementary tool to GK13S for the investigation of UCHL1 function in cellular studies [1].Fórmula:C11H15N3OCor e Forma:SolidPeso molecular:205.12151Ga-CY03
Ga-CY03 (compound) is a FAP-tracing molecule designed based on the FAP inhibitor QI-18 and labeled with [Ga].Fórmula:C53H63F2GaN13O15Cor e Forma:SolidPeso molecular:1229.87UBD1031
UBD1031 exhibits strong affinity for the ubiquitin-binding domain (UBD) of USP16, with a dissociation constant (KD) of 48 nM. It inhibits the interaction between USP16 and ISG15, displaying an effective concentration (EC50) of 1.7 nM. UBD1031 can serve as a chemical probe for investigating USP16 UBD.Cor e Forma:Odour SolidBAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective inhibitor of USP21 [1].Fórmula:C24H28F3N5O2SCor e Forma:SolidPeso molecular:507.57JAMM protein inhibitor 2
CAS:JAMM inhibitor 2 targets thrombin, Rpn11, MMP2 with IC50s 10, 46, 89 μM, aids cancer research.Fórmula:C21H26N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:338.4433MS7131
MS7131 is a DUBTAC inhibitor that recruits USP1. It effectively reduces histone H3 lysine 27 trimethylation and significantly inhibits the proliferation and colony-forming ability of cancer cells.Cor e Forma:Odour SolidVLX 1500
CAS:VLX 1500 is a potent DUBs inhibitor; blocks USP14/UCHL5; induces lethal ubiquitinated protein accumulation and ER stress apoptosis; overcomes proteasome resistance.Fórmula:C22H17N3O6Peso molecular:419.39USP7-IN-16
CAS:USP7-IN-16 (Compound 61) is a selective inhibitor of USP7, with IC50 values of 5.5 nM in the FLINT assay and 2.1 nM in MM.1S cells. This compound exhibits antitumor activity in mice and holds potential for research in the field of oncology.Fórmula:C43H45N7O6SCor e Forma:SolidPeso molecular:787.93USP7-055
CAS:USP7-055 is an inhibitor of USP7, utilized in cancer research.Fórmula:C27H29ClN4O2SCor e Forma:SolidPeso molecular:509.06Q14
Q14 is a polypeptide derived from the transmembrane (TM) domain of USP30 (ubiquitin specific peptidase30) and is capable of inhibiting the deubiquitination activity of USP30 (IC50=57.2 nM). By hindering the interaction between USP30’s transmembrane and catalytic domains, it lowers USP30 activity. The Q14 polypeptide contains an LC3 interaction region (LIR) motif, enabling it to bind with LC3, thereby accelerating autophagosome formation and promoting mitophagy. Q14 is applicable in the study of neurodegenerative diseases, mitochondrial quality control, and cellular metabolism.Fórmula:C101H168N32O23Cor e Forma:SolidPeso molecular:2197.29601EN523
CAS:EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.Fórmula:C12H14N2O3Pureza:99.5%Cor e Forma:White SolidPeso molecular:234.2512PROTAC USP7 Degrader-1
PROTACUSP7 Degrader-1 (Compound 40) is a PROTAC degrader specifically targeting ubiquitin-specific protease 7 (USP7) with a DC50 of 25 nM. It is utilized in cancer research, including studies on acute myeloid leukemia.FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Fórmula:C25H29N5OSCor e Forma:SolidPeso molecular:447.596USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Fórmula:C18H21N5O3SPureza:99.07%Cor e Forma:SoildPeso molecular:387.456LN5P45
CAS:LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis.Fórmula:C13H15ClN2O2Cor e Forma:SolidPeso molecular:266.72STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Fórmula:C19H19N3O4S2Pureza:98.77% - 99.64%Cor e Forma:SolidPeso molecular:417.502USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Cor e Forma:SolidPeso molecular:484.399
