Receptor Endotelina
Os receptores de endotelina são GPCRs que mediam os efeitos das endotelinas, potentes peptídeos vasoconstritores que desempenham um papel significativo na regulação do tônus vascular, controle da pressão arterial e proliferação celular. Antagonistas dos receptores de endotelina são usados no tratamento de condições como hipertensão arterial pulmonar e insuficiência cardíaca. Esses receptores também são alvos importantes na pesquisa sobre doenças cardiovasculares e câncer. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores de endotelina de alta qualidade para apoiar sua pesquisa em biologia cardiovascular, oncologia e fisiologia vascular.
Foram encontrados 86 produtos de "Receptor Endotelina"
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Atrasentan sodium
CAS:Atrasentan (ABT-627) is an oral ETA receptor blocker with potential cancer-fighting properties, inhibiting angiogenesis and tumor growth.Fórmula:C29H37N2NaO6Cor e Forma:SolidPeso molecular:532.61Ro 46-2005
CAS:Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).Fórmula:C23H27N3O6SPureza:98.02% - 98.8%Cor e Forma:SolidPeso molecular:473.54RO 46-8443
CAS:RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.Fórmula:C31H35N3O8SPureza:98.77% - 99.77%Cor e Forma:SolidPeso molecular:609.69Bosentan (hydrate)
CAS:Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.Fórmula:C27H29N5O6S·H2OPureza:99.31% - 99.86%Cor e Forma:White PowderPeso molecular:569.63Ambrisentan
CAS:Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.Fórmula:C22H22N2O4Pureza:99.65% - 99.86%Cor e Forma:SolidPeso molecular:378.42Atrasentan
CAS:Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.Fórmula:C29H38N2O6Pureza:97.65% - 99.08%Cor e Forma:SolidPeso molecular:510.62Ref: TM-TQ0259
1mg46,00€5mg90,00€10mg130,00€25mg250,00€50mg356,00€100mg580,00€200mg798,00€1mL*10mM (DMSO)109,00€Aprocitentan
CAS:Aprocitentan (ACT-132577) is ETA and ETB antagonist .Fórmula:C16H14Br2N6O4SPureza:99.17%Cor e Forma:SolidPeso molecular:546.19Ref: TM-T7817
1mg58,00€5mg116,00€10mg170,00€25mg311,00€50mg439,00€100mg655,00€200mg887,00€1mL*10mM (DMSO)142,00€Sparsentan
CAS:Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,Fórmula:C32H40N4O5SPureza:97.94% - 98.69%Cor e Forma:SolidPeso molecular:592.75Ref: TM-T5355
2mg37,00€5mg55,00€10mg89,00€25mg161,00€50mg245,00€100mg360,00€200mg512,00€1mL*10mM (DMSO)73,00€BMS 182874 hydrochloride
CAS:BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.Fórmula:C17H20ClN3O3SPureza:97.01%Cor e Forma:SolidPeso molecular:381.88Ref: TM-T21790
1mg77,00€2mg92,00€5mg140,00€10mg205,00€25mg343,00€50mg477,00€100mg665,00€200mg897,00€1mL*10mM (DMSO)146,00€ANP(1-28) Acetate (human, porcine)
CAS:Carperitide acetate: 28-amino acid hormone from human heart, counters cardiac injury/stretch, reduces endothelin-1.Fórmula:C129H207N45O41S3Pureza:98.24%Cor e Forma:SolidPeso molecular:3140.5Ref: TM-TP1220L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.388,00€100mg1.872,00€200mg2.527,00€Macitentan
CAS:Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).Fórmula:C19H20Br2N6O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:588.27Endothelin-2 (49-69), human
CAS:Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.Fórmula:C115H160N26O32S4Pureza:98.26%Cor e Forma:SolidPeso molecular:2546.92Nebentan potassium
CAS:Nebentan potassium (YM598) is an ETA receptor antagonist that inhibits pulmonary arterial hypertension and is used in the study of neurologic diseases.Fórmula:C24H20KN5O5SPureza:99.05%Cor e Forma:SolidPeso molecular:529.61Ref: TM-T36008
1mg52,00€2mg77,00€5mg111,00€10mg177,00€25mg313,00€50mg502,00€100mg680,00€200mg888,00€1mL*10mM (DMSO)133,00€Zibotentan
CAS:Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.Fórmula:C19H16N6O4SPureza:97.00% - 97.02%Cor e Forma:SolidPeso molecular:424.43TBC3711
CAS:TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders.Fórmula:C20H21N3O5S2Pureza:98%Cor e Forma:SolidPeso molecular:447.53ZD-1611
CAS:ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke.Fórmula:C22H24N4O5SPureza:98%Cor e Forma:SolidPeso molecular:456.51CH 141
CAS:CH 141 is a new type of peripheral vasodilator.Fórmula:C19H21N3OCor e Forma:SolidPeso molecular:307.39ABT-546
CAS:ABT-546 is a potent, selective endothelin ETA receptor antagonist, Ki 0.46 nM for [125I]ET-1 binding.Fórmula:C30H48N2O6Pureza:98%Cor e Forma:SolidPeso molecular:532.71BMS-193884
CAS:BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.Fórmula:C20H17N3O4SCor e Forma:SolidPeso molecular:395.43CI 1020
CAS:endothelin-A receptor (ETA) antagonistFórmula:C28H26O9Pureza:98%Cor e Forma:SolidPeso molecular:506.5
