Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Foram encontrados 46 produtos de "Receptor Sigma"
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Roluperidone
CAS:<p>Roluperidone (CYR-101) is a novel cyclic amide derivative.</p>Fórmula:C22H23FN2O2Pureza:96.46% - 97.77%Cor e Forma:SolidPeso molecular:366.43Glycerol phenylbutyrate
CAS:<p>Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).</p>Fórmula:C33H38O6Pureza:98.54% - 99.74%Cor e Forma:SolidPeso molecular:530.65Blonanserin
CAS:<p>Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.</p>Fórmula:C23H30FN3Pureza:99.85%Cor e Forma:SolidPeso molecular:367.5AD353
<p>AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.</p>Fórmula:C23H30N2O2Cor e Forma:SolidPeso molecular:366.5σ1 Receptor ligand 1
<p>σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.</p>Fórmula:C22H28N2O2Cor e Forma:SolidPeso molecular:352.47PD 144418 oxalate
CAS:<p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>Fórmula:C20H24N2O5Pureza:98.76%Cor e Forma:SolidPeso molecular:372.42KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Fórmula:C24H32N2O8Pureza:98.12%Cor e Forma:SolidPeso molecular:476.52UKH-1114
CAS:<p>UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.</p>Fórmula:C22H24F3NOCor e Forma:SolidPeso molecular:375.43AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Fórmula:C25H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:438.52Sigma-1 receptor antagonist 4
<p>Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced</p>Fórmula:C22H26N2OCor e Forma:SolidPeso molecular:334.45σ1R-IN-1
<p>σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.</p>Fórmula:C15H22N2Cor e Forma:SolidPeso molecular:230.35AD186
<p>AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.</p>Fórmula:C22H28N2Pureza:98%Cor e Forma:SolidPeso molecular:320.47AB21 HCl
<p>AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.</p>Fórmula:C23H29ClN2OPureza:99.91%Cor e Forma:SolidPeso molecular:384.2S1R agonist 2 hydrochloride
<p>Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.</p>Fórmula:C21H28ClNOPureza:98%Cor e Forma:SolidPeso molecular:345.914-IBP
CAS:<p>4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .</p>Fórmula:C19H21IN2OPureza:98.99%Cor e Forma:SolidPeso molecular:420.29Blarcamesine hydrochloride
CAS:<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Fórmula:C19H24ClNOPureza:99.57% - 99.9%Cor e Forma:SolidPeso molecular:317.85Cutamesine dihydrochloride
CAS:<p>Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.</p>Fórmula:C23H32N2O2·2HClPureza:99.96%Cor e Forma:SolidPeso molecular:441.43σ1 Receptor antagonist-1
CAS:<p>σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.</p>Fórmula:C21H23NOSPureza:99.8%Cor e Forma:SolidPeso molecular:337.48BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Fórmula:C15H24Br2Cl2N2Pureza:97.81%Cor e Forma:SolidPeso molecular:463.08PRE-084 hydrochloride
CAS:<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Fórmula:C19H28ClNO3Pureza:99.54%Cor e Forma:SolidPeso molecular:353.88
