Receptor opioide
Os receptores opioides são um grupo de receptores acoplados à proteína G que mediam os efeitos dos opioides endógenos e exógenos. Estes receptores desempenham um papel central na modulação da dor, regulação do humor e comportamentos aditivos. Agonistas e antagonistas dos receptores opioides são amplamente utilizados no manejo da dor e tratamento de dependências, bem como em pesquisas sobre distúrbios neurológicos e psiquiátricos. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores opioides de alta qualidade para apoiar sua pesquisa em neurobiologia, manejo da dor e terapia de dependência.
Foram encontrados 321 produtos de "Receptor opioide"
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KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Fórmula:C38H38N2O5Cor e Forma:SolidPeso molecular:602.72[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS:'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'Fórmula:C76H128N24O15Cor e Forma:SolidPeso molecular:1617.98Naldemedine
CAS:Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.Fórmula:C32H34N4O6Cor e Forma:SolidPeso molecular:570.64Dafphedyn
CAS:Dafphedyn (DAFPHEDYN), a potent endorphin 1-13 analog, induces diuresis and analgesia in rats via IV.Fórmula:C76H124F5N25O14Cor e Forma:SolidPeso molecular:1706.95Ro 64-6198
CAS:<p>Ro 64-6198: Nonpeptide, selective NOP agonist, high brain uptake, EC50=25.6 nM, 100x NOP>opioid affinity.</p>Fórmula:C26H31N3OPureza:98%Cor e Forma:SolidPeso molecular:401.54UFP-101
CAS:<p>Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.</p>Fórmula:C82H138N32O21Pureza:98%Cor e Forma:SolidPeso molecular:1908.19Neuropeptide AF (human) acetate
<p>Neuropeptide AF (human) acetate (Neuropeptide AF (human) acetate (192387-38-5 Free base)) is an anti-opioid neuropeptide, a Neuropeptide AF (human) derivative,</p>Pureza:99.89%Cor e Forma:SoildHINT1-IN-1
<p>HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).</p>Fórmula:C23H24N8O5Cor e Forma:SolidPeso molecular:492.49[Arg14,Lys15]Nociceptin
CAS:Potent NOP agonist (EC50 = 1 nM), >875x selective vs opioid receptors; outperforms nociceptin in vivo, increases pain perception, reduces movement.Fórmula:C82H137N31O22Pureza:98%Cor e Forma:SolidPeso molecular:1909.18KOR agonist 4
<p>KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.</p>Fórmula:C21H25N3Cor e Forma:SolidPeso molecular:319.44β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Fórmula:C156H249F3N42O46SCor e Forma:SolidPeso molecular:3537.96N-Desmethyl Loperamide
CAS:N-Desmethyl Loperamide is the major metabolite of loperamide. It is also used as the precusor for radiolabelled loperamide.Fórmula:C28H31ClN2O2Cor e Forma:SolidPeso molecular:463.01β-Endorphin, equine
CAS:Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain.Fórmula:C154H248N42O44SPureza:98%Cor e Forma:SolidPeso molecular:3423.94Akuammicine
CAS:<p>Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.</p>Fórmula:C20H22N2O2Cor e Forma:SolidPeso molecular:322.408difelikefalin acetate(1024828-77-0 Free base)
CAS:<p>is a ketone and a building block.</p>Fórmula:C38H57N7O8Pureza:96.94%Cor e Forma:SolidPeso molecular:739.9(S,S)-J-113397
CAS:(S,S)-J-113397 is an isomer of J-113397 . J-113397 is an Opioid Receptor antagonist [1] .Fórmula:C24H37N3O2Cor e Forma:SolidPeso molecular:399.57[(pF)Phe4]Nociceptin(1-13)NH2
CAS:<p>Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.</p>Fórmula:C61H99FN22O15Pureza:98%Cor e Forma:SolidPeso molecular:1399.6Frakefamide TFA
<p>Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.</p>Fórmula:C32H35F4N5O7Cor e Forma:SolidPeso molecular:677.64R-6890
CAS:<p>R-6890 is an opioid compound with analgesic properties.</p>Fórmula:C21H24ClN3OCor e Forma:SolidPeso molecular:369.89(-)-9-Hydroxycorynantheidine
CAS:<p>(-)-9-Hydroxycorynantheidine (9-O-Desmethyl mitragynine) is a demethylated analog of Mitragynine, functioning as a selective and partial agonist for the μ-opioid receptor (μ-opioid receptor). This compound inhibits electrically stimulated twitch contractions in the guinea pig ileum.</p>Fórmula:C22H28N2O4Cor e Forma:SolidPeso molecular:384.47
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