Receptor opioide
Os receptores opioides são um grupo de receptores acoplados à proteína G que mediam os efeitos dos opioides endógenos e exógenos. Estes receptores desempenham um papel central na modulação da dor, regulação do humor e comportamentos aditivos. Agonistas e antagonistas dos receptores opioides são amplamente utilizados no manejo da dor e tratamento de dependências, bem como em pesquisas sobre distúrbios neurológicos e psiquiátricos. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores opioides de alta qualidade para apoiar sua pesquisa em neurobiologia, manejo da dor e terapia de dependência.
Foram encontrados 330 produtos para "Receptor opioide".
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Gluten Exorphin B5
CAS:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.Fórmula:C30H38N6O7Pureza:98%Cor e Forma:SolidPeso molecular:594.66Herkinorin
CAS:Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.Fórmula:C28H30O8Cor e Forma:SolidPeso molecular:494.53NP-5497-KA
NP-5497-KA is a κ-opioid receptor agonist with oral bioavailability.Fórmula:C26H39Cl3N4O2Cor e Forma:SolidPeso molecular:544.21386TAN67
CAS:TAN67 is the first effective selective non-peptide delta1 opioid receptor.Fórmula:C23H26Br2N2OCor e Forma:SolidPeso molecular:506.282Dynorphin B (1-13)
CAS:Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.Fórmula:C74H115N21O17Pureza:98%Cor e Forma:SolidPeso molecular:1570.84Neuropeptide AF (human)
CAS:Neuropeptide AF (93-110), Human is an endogenous antiopioid peptide.Fórmula:C90H132N26O25Pureza:98%Cor e Forma:SolidPeso molecular:1978.17CTAP
CAS:Potent μ opioid antagonist, IC50 3.5 nM, 1200x selectivity over δ and somatostatin, brain-penetrant, active in vivo.Fórmula:C51H69N13O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1104.32δ opioid receptor antagonist 1
Compound 6-Cy3, a δ-opioid receptor antagonist, serves as a highly selective fluorescent probe for δ-opioid receptors (DOR), showcasing an affinity (Ki=1.7 nM). This compound is used in the study of pain perception mechanisms.Cor e Forma:Odour Solid(Rac)-SNC80
CAS:(Rac)-SNC80, a racemic δ-opioid agonist (K i 1.78 nM), shows potential for treating various headache disorders.Fórmula:C28H39N3O2Cor e Forma:SolidPeso molecular:449.63β-Naltrexamine dihydrochloride
CAS:β-Naltrexamine dihydrochloride is an orally administered, irreversible opioid receptor antagonist. Its derivatives exhibit optimised subtype selectivity and can be used for pain research.Fórmula:C20H28Cl2N2O3Pureza:95.98%Cor e Forma:SolidPeso molecular:415.35ICI 174,864
CAS:Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.Fórmula:C38H53N5O7Pureza:98%Cor e Forma:White SolidPeso molecular:691.87CTOP
CAS:Potent μ-receptor antagonist, Ki=0.96nM, ineffective at δ (>10,000nM). Alters behavior in vivo, boosts K+ currents in rat neurons in vitro, μ-independent.Fórmula:C50H67N11O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1062.28Cebranopadol hemicitrate
CAS:Cebranopadol hemicitrate is a NOP and opioid receptor agonist that targets human NOP, MOP, KOP, and δ-opioid peptide (DOP) receptors, with Ki/EC50 values of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, and 18 nM/110 nM, respectively. It is used in studies of acute and chronic pain.Cor e Forma:SolidUFP-101
CAS:Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.Fórmula:C82H138N32O21Pureza:98%Cor e Forma:SolidPeso molecular:1908.19Dermorphin
CAS:Dermorphin is agonist of μ-opioid receptor (MOR) agonist.Fórmula:C40H50N8O10Pureza:98.82%Cor e Forma:White SolidPeso molecular:802.87μ/κ/δ opioid receptor agonist 1
μ/κ/δopioid receptor agonist1 is an agonist for the μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR). It produces potent and long-lasting analgesic effects in the tail flick test through peripheral MOR and KOR activation.Fórmula:C35H45FN8O8Cor e Forma:SolidPeso molecular:724.33444N-Formyl-MMYALF TFA
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide known for its ability to deplete calcium ions in the endoplasmic reticulum. Additionally, it inhibits the FPR-1-mediated chemotactic response of PMNs to bacterial peptides.Fórmula:C38H54N6O9S2·xC2HF3O2Peso molecular:803.00 (free base)Naldemedine
CAS:Naldemedine (S 297995), developed by Shionogi, is a drug for opioid side effects like constipation. It's well tolerated with minor GI issues.Fórmula:C32H34N4O6Cor e Forma:SolidPeso molecular:570.64KOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Fórmula:C21H25N3Cor e Forma:SolidPeso molecular:319.44HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Fórmula:C23H24N8O5Cor e Forma:SolidPeso molecular:492.49
