SGLT
Os co-transportadores sódio-glicose (SGLT) são proteínas de membrana que facilitam a reabsorção de glicose nos rins ao acoplar o transporte de glicose aos íons de sódio. Inibidores de SGLT são uma classe importante de medicamentos usados no tratamento do diabetes tipo 2, pois ajudam a reduzir os níveis de glicose no sangue ao prevenir a reabsorção de glicose nos túbulos renais. Esses inibidores também estão sendo investigados por seus potenciais benefícios na proteção cardiovascular e renal. Na CymitQuimica, oferecemos uma gama de moduladores de SGLT de alta qualidade para apoiar sua pesquisa em diabetes, fisiologia renal e distúrbios metabólicos.
Foram encontrados 34 produtos para "SGLT".
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Sergliflozin A
CAS:Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia.Fórmula:C20H24O7Pureza:99.71%Cor e Forma:SolidPeso molecular:376.4004KGA-2727
CAS:KGA-2727: potent, selective SGLT1 inhibitor (human Ki 97.4 nM, rat 43.5 nM), with high selectivity over SGLT2 for diabetes treatment.Fórmula:C26H40N4O8Pureza:98.46%Cor e Forma:SolidPeso molecular:536.6178O-Desethyl Dapagliflozin
CAS:O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.Fórmula:C19H21ClO6Pureza:98.33%Cor e Forma:Yellow OilPeso molecular:380.819SGLT2-IN-4
SGLT2-IN-4 (Compound 1) is a selective and orally active inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2). It increases the proportion of α-helices in proteins and enhances the stability of the SGLT2-D201A mutant. SGLT2-IN-4 is applicable in research for type 2 diabetes.Empagliflozin-d8
CAS:Empagliflozin-d8 is the deuterium-labeled form of Empagliflozin. Empagliflozin (BI 10773) acts as a selective inhibitor of the sodium-glucose co-transporter-2 (SGLT-2), exhibiting an IC50 value of 3.1 nM for human SGLT-2.Fórmula:C23H27ClO7Peso molecular:458.96Dapagliflozin (Standard)
CAS:Dapagliflozin (Standard) is the standard for Dapagliflozin (T2389). Dapagliflozin is a competitive sodium-glucose cotransporter 2 (SGLT2) inhibitor that can reduce renal glucose reabsorption and promote urinary glucose excretion. Dapagliflozin can also inhibit renal mesangial cell fibrosis by regulating the HO-1/TGF-β1/Smad2/3 axis, and is related to research on glucose transport, renal cell responses, and fibrosis signaling. Dapagliflozin can also be used in research on SGLT2 pharmacology and mechanisms of renal fibrosis-related pathways.Fórmula:C21H25ClO6Peso molecular:408.87Canagliflozin (Standard)
CAS:Canagliflozin (Standard) is the standard substance of Canagliflozin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).Fórmula:C24H25FO5SCor e Forma:SolidPeso molecular:444.52T-1095
CAS:T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).Fórmula:C26H28O11Pureza:99.78%Cor e Forma:SolidPeso molecular:516.4939Tofogliflozin (hydrate)
CAS:Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(Ki of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).Fórmula:C22H28O7Pureza:97.03% - 98.78%Cor e Forma:White SolidPeso molecular:404.4535Phlorizin
CAS:Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .Fórmula:C21H24O10Pureza:99.73% - 99.77%Cor e Forma:Solid CrystallinePeso molecular:436.41Sotagliflozin
CAS:Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potentialFórmula:C21H25ClO5SPureza:99% - 99.86%Cor e Forma:SolidPeso molecular:424.938Dapagliflozin ((2S)-1,2-propanediol, hydrate)
CAS:Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-Fórmula:C24H35ClO9Pureza:99.88% - 99.94%Cor e Forma:SolidPeso molecular:502.98Mizagliflozin
CAS:Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1.Cost-effective and quality-assured.Fórmula:C28H44N4O8Pureza:98.66% - 99.67%Cor e Forma:SolidPeso molecular:564.671Canagliflozin
CAS:Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.Fórmula:C24H25FO5SPureza:98.01% - >99.99%Cor e Forma:White SolidPeso molecular:444.52Ipragliflozin
CAS:Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.Fórmula:C21H21FO5SPureza:99.38% - 99.70%Cor e Forma:White SolidPeso molecular:404.45Phloretin
CAS:Phloretin (NSC-407292) inhibits eukaryotic urea transporters, has antioxidative properties, and can induce cancer cell apoptosis. Found in apples and apricots.Fórmula:C15H14O5Pureza:98.53% - >99.99%Cor e Forma:White SolidPeso molecular:274.2687Ertugliflozin
CAS:PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).Fórmula:C22H25ClO7Pureza:99.89% - 99.96%Cor e Forma:SolidPeso molecular:436.883Bexagliflozin
CAS:Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 2 nM for human SGLT2.Fórmula:C24H29ClO7Pureza:98.99% - 99.89%Cor e Forma:SolidPeso molecular:464.936Empagliflozin
CAS:Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6.Fórmula:C23H27ClO7Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:450.91Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFórmula:C21H24O10Pureza:97.16%Cor e Forma:SolidPeso molecular:436.4093
