PKA
A proteína quinase A (PKA) é uma enzima chave na cascata de sinalização GPCR, ativada pelo AMP cíclico (cAMP) em resposta a vários sinais extracelulares. A PKA regula uma ampla gama de processos celulares, incluindo metabolismo, expressão gênica e crescimento celular. A desregulação da atividade da PKA está associada a várias doenças, incluindo câncer, distúrbios metabólicos e condições cardiovasculares. Moduladores de PKA são ferramentas valiosas na pesquisa destinada a compreender as vias de sinalização GPCR e desenvolver novas estratégias terapêuticas. Na CymitQuimica, oferecemos uma seleção de moduladores de PKA de alta qualidade para apoiar sua pesquisa em transdução de sinal, regulação celular e mecanismos de doenças.
Foram encontrados 63 produtos para "PKA".
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Kemptide Phospho-Ser5
Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).Fórmula:C32H62N13O12PPureza:98%Cor e Forma:SolidPeso molecular:851.89PKG Substrate
CAS:PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).Fórmula:C35H67N17O11Pureza:98%Cor e Forma:SolidPeso molecular:902.01AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Fórmula:C18H16N4SPureza:99.99%Cor e Forma:SoildPeso molecular:320.41Malantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Fórmula:C74H125F3N22O23Cor e Forma:SolidPeso molecular:1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS:H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].Fórmula:C31H58N14O9Cor e Forma:SolidPeso molecular:770.88PKA-IN-1
CAS:PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFórmula:C13H11N3OPureza:99.12%Cor e Forma:SolidPeso molecular:225.25PKI (5-24),amide
CAS:PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.Fórmula:C94H149N33O30Cor e Forma:SolidPeso molecular:2221.4PKItide
CAS:PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].Fórmula:C85H149N31O24Pureza:98%Cor e Forma:SolidPeso molecular:1989.29STAD 2
CAS:STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFórmula:C102H182N24O22Cor e Forma:SolidPeso molecular:2096.724Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.97%Cor e Forma:SolidPeso molecular:291.37DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Fórmula:C152H258N52O28S·xC2H4O2Cor e Forma:SolidPeso molecular:3294.07 (free acid)AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Cor e Forma:SolidPeso molecular:313.78HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Cor e Forma:Pale Yellow Crystalline SolidPeso molecular:277.34Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.82%Cor e Forma:Off-White PowderPeso molecular:466.53Ref: TM-T6680
1mg58,00€2mg82,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg234,00€50mg380,00€100mg565,00€500mg1.215,00€8-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Fórmula:C10H10BrN5NaO6PPureza:98% - 99.94%Cor e Forma:Off-White PowderPeso molecular:430.08Iso-H7 dihydrochloride
CAS:Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Fórmula:C14H19Cl2N3O2SPureza:99.53%Cor e Forma:White Crystalline SolidPeso molecular:364.29CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Cor e Forma:SolidPeso molecular:499.5Ref: TM-T3498
1mg56,00€5mg114,00€1mL*10mM (DMSO)127,00€10mg178,00€25mg394,00€50mg655,00€100mg1.035,00€AT7867
CAS:AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Fórmula:C20H20ClN3Pureza:99.63%Cor e Forma:SolidPeso molecular:337.85Ref: TM-T6304
2mg42,00€5mg62,00€1mL*10mM (DMSO)62,00€10mg81,00€25mg128,00€50mg198,00€100mg296,00€200mg427,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Fórmula:C9H6O4Pureza:97.47% - 99.95%Cor e Forma:SolidPeso molecular:178.14Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Fórmula:C31H20O10Pureza:97% - 99.69%Cor e Forma:SolidPeso molecular:552.48Ref: TM-T4S2128
1mg44,00€2mg66,00€5mg137,00€1mL*10mM (DMSO)177,00€10mg236,00€25mg403,00€50mg582,00€100mg800,00€
