PKA
A proteína quinase A (PKA) é uma enzima chave na cascata de sinalização GPCR, ativada pelo AMP cíclico (cAMP) em resposta a vários sinais extracelulares. A PKA regula uma ampla gama de processos celulares, incluindo metabolismo, expressão gênica e crescimento celular. A desregulação da atividade da PKA está associada a várias doenças, incluindo câncer, distúrbios metabólicos e condições cardiovasculares. Moduladores de PKA são ferramentas valiosas na pesquisa destinada a compreender as vias de sinalização GPCR e desenvolver novas estratégias terapêuticas. Na CymitQuimica, oferecemos uma seleção de moduladores de PKA de alta qualidade para apoiar sua pesquisa em transdução de sinal, regulação celular e mecanismos de doenças.
Foram encontrados 60 produtos de "PKA"
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Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Cor e Forma:White SolidPeso molecular:327.83PKG drug G1
CAS:PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Fórmula:C13H11N3OSPureza:97.57% - 97.67%Cor e Forma:SolidPeso molecular:257.31CREBtide acetate(149155-45-3 free base)
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Fórmula:C75H133N29O21Pureza:96.13%Cor e Forma:SolidPeso molecular:1777.07HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Cor e Forma:Pale Yellow Crystalline SolidPeso molecular:277.34PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).Fórmula:C40H75F3N18O12Pureza:98%Cor e Forma:SolidPeso molecular:1057.13PKI (5-24) Acetate(99534-03-9 free base)
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).Fórmula:C96H152N32O33Pureza:99.47%Cor e Forma:SolidPeso molecular:2282.43PKG Substrate acetate(81187-14-6 free base)
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with aFórmula:C37H71N17O13Pureza:99.30%Cor e Forma:SolidPeso molecular:962.08Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Fórmula:C14H17N3O3SPureza:98.13%Cor e Forma:SolidPeso molecular:307.37H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Cor e Forma:SolidPeso molecular:519.28Ref: TM-T6250
5mg39,00€10mg58,00€25mg106,00€50mg202,00€100mg344,00€200mg512,00€500mg815,00€1mL*10mM (DMSO)52,00€Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Cor e Forma:Off-White PowderPeso molecular:298.29H-8 hydrochloride
CAS:H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Fórmula:C12H17Cl2N3O2SPureza:99.93%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:338.256-Bn-cAMP
CAS:6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.Fórmula:C17H18N5O6PCor e Forma:SolidPeso molecular:419.338-Chloro-cAMP sodium
CAS:8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.Fórmula:C10H10ClN5NaO6PCor e Forma:SolidPeso molecular:385.638-MA-cAMP
CAS:8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.Fórmula:C11H15N6O6PCor e Forma:SolidPeso molecular:358.25BGC201531
CAS:BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.
Fórmula:C26H28N2O6SPureza:98.51% - 99.33%Cor e Forma:SolidPeso molecular:496.58Rp-cAMPS triethylammonium salt
CAS:Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Fórmula:C16H27N6O5PSPureza:98%Cor e Forma:SolidPeso molecular:446.46FMP-API-1
CAS:FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).Fórmula:C13H14N2O2Cor e Forma:SolidPeso molecular:230.262Protein kinase inhibitor 7
CAS:Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Fórmula:C12H15N3O2SPeso molecular:265.338-Br-cGMP-AM
CAS:8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.Fórmula:C13H15BrN5O9PCor e Forma:SolidPeso molecular:496.16PET-cGMP
CAS:PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.
Fórmula:C18H16N5O7PCor e Forma:SolidPeso molecular:445.323
