GPCR19
GPCR19, também conhecido como GPR19, é um membro da família dos receptores acoplados à proteína G, com funções que ainda estão sendo elucidadas em vários processos fisiológicos. Embora menos caracterizado do que outros GPCRs, o GPCR19 é de interesse em pesquisas focadas na descoberta de novos alvos terapêuticos para doenças metabólicas, câncer e distúrbios neurológicos. Na CymitQuimica, oferecemos uma seleção de ferramentas de pesquisa e reagentes para apoiar suas investigações sobre as funções e potenciais aplicações terapêuticas do GPCR19.
Foram encontrados 36 produtos de "GPCR19"
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Deoxycholic acid
CAS:Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.Fórmula:C24H40O4Pureza:99.91% - 99.91%Cor e Forma:Crystals From Alc SolidPeso molecular:392.57Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.74% - ≥95%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57Hyodeoxycholic acid
CAS:Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.Fórmula:C24H40O4Pureza:97.29% - 98.82%Cor e Forma:SolidPeso molecular:392.57TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Fórmula:C29H50NNaO6SCor e Forma:SolidPeso molecular:563.77TGR5 agonist 6
CAS:Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.Fórmula:C42H48Cl2N6O6Cor e Forma:SolidPeso molecular:803.77TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].Fórmula:C28H48NNaO6SCor e Forma:SolidPeso molecular:549.74TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].Fórmula:C24H38F2O5Cor e Forma:SolidPeso molecular:444.55PEN (human)
CAS:PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C97H159N27O32Pureza:98%Cor e Forma:SolidPeso molecular:2215.49Cholic Acid 7-sulfate
CAS:Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.Fórmula:C24H40O8SCor e Forma:SolidPeso molecular:488.64TGR5 agonist 7
TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.Fórmula:C37H59N2NaO9SCor e Forma:SolidPeso molecular:730.93PEN (rat)
CAS:PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C102H169N27O33Pureza:98%Cor e Forma:SolidPeso molecular:2301.625-HT7R antagonist 1 free base
CAS:5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.Fórmula:C14H17ClN4Cor e Forma:SolidPeso molecular:276.77Triamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Fórmula:C12H11N7Pureza:99.77%Cor e Forma:Yellow Yellow SolidPeso molecular:253.26Neuromedin S (human)
CAS:Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting onCor e Forma:SolidTriamterene (Standard)
CAS:Triamterene (Standard) is the standard substance of Triamterene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Fórmula:C12H11N7Cor e Forma:Yellow Yellow SolidPeso molecular:253.26TC-G 1005
CAS:TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5).Fórmula:C25H25N3O2Pureza:98.60% - 99.78%Cor e Forma:SolidPeso molecular:399.48Ref: TM-T8818
1mg34,00€2mg43,00€5mg65,00€1mL*10mM (DMSO)72,00€10mg90,00€25mg178,00€50mg269,00€100mg400,00€SB756050
CAS:SB756050 is a specific TGR5 agonist.Fórmula:C21H28N2O8S2Pureza:98.78% - >99.99%Cor e Forma:SolidPeso molecular:500.59Ursodeoxycholic acid sodium
CAS:Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.Fórmula:C24H40NaO4Pureza:99.66% - 99.96%Cor e Forma:SolidPeso molecular:415.56BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Cor e Forma:SolidPeso molecular:392.62TGR5 Receptor Agonist
CAS:TGR5 is a potent TGR5(GPCR19) agonist.Fórmula:C18H14Cl2N2O2Pureza:99.77% - ≥95%Cor e Forma:SolidPeso molecular:361.22BAR501
CAS:BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。Fórmula:C26H46O3Pureza:99.29% - 99.68%Cor e Forma:SolidPeso molecular:406.64SBI-115
CAS:SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5Fórmula:C14H13ClN2O4SPureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:340.78PEN (human) aceate
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.Fórmula:C99H163N27O34Pureza:99.25%Cor e Forma:SolidPeso molecular:2275.51Deoxycholic acid sodium salt
CAS:Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates BAT thermogenic activity.Fórmula:C24H39NaO4Pureza:97.88% - 99.84%Cor e Forma:Cream Crystalline PowderPeso molecular:414.56CAY10789
CAS:CAY10789: potent CysLT1R antagonist (IC50 2.8 µM), GPBAR1 agonist (EC50 3 µM), reduces U937 cell adhesion, TNF-α, stable with promising pharmacokinetics.Fórmula:C17H15NO2Cor e Forma:SolidPeso molecular:265.31WB403
CAS:WB403 activates TGR5, lowers fasting/postprandial glucose and HbA1c, enhances glucose tolerance, and normalizes pancreatic α/β-cells in diabetic mice.Fórmula:C19H19BrN2OSPureza:98%Cor e Forma:SolidPeso molecular:403.34TGR5 Receptor Agonist 4
CAS:TGR5 Receptor Agonist 4, a selective agonist for the Bile Acid Receptor (TGR5), exhibits potent activity with an EC50 of 2 nM for human TGR5 (hTGR5) and 3 nMFórmula:C25H27ClN2O5Cor e Forma:SolidPeso molecular:470.95INT-777 R-enantiomer
CAS:INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.Fórmula:C27H46O5Pureza:98%Cor e Forma:SolidPeso molecular:450.65RO5527239
CAS:RO5527239 is a potent, orally available GPBAR1 agonist agent.Fórmula:C28H31N3O3Pureza:98%Cor e Forma:SolidPeso molecular:457.56TGR5 agonist 3
CAS:Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].Fórmula:C28H48O5Cor e Forma:SolidPeso molecular:464.68INT-777
CAS:INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.Fórmula:C27H46O5Pureza:99.78%Cor e Forma:SolidPeso molecular:450.65Ref: TM-T11662L
1mg130,00€5mg313,00€1mL*10mM (DMSO)343,00€10mg447,00€25mg715,00€50mg999,00€100mg1.395,00€5-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.Fórmula:C14H18Cl2N4Cor e Forma:SolidPeso molecular:313.23GPBAR1-IN-3
CAS:GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].Fórmula:C21H23NO2Cor e Forma:SolidPeso molecular:321.41LT-188A
CAS:LT-188A is a potent TGR5 agonist with an EC50 value of 23 μM. It effectively reduces levels of inflammatory mediators in macrophages.Fórmula:C28H36O7Cor e Forma:SolidPeso molecular:484.585β-Cholestane-3α,7α,12α,25-tetrol
CAS:5β-Cholestane-3α,7α,12α,25-tetrol is a type of bile acid alcohol that activates the G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells that express the human receptor, at concentrations between 0.1 to 10 µM. In individuals with cerebrotendinous xanthomatosis (CTX), a progressive metabolic leukodystrophy, levels of this compound are elevated in the blood, feces, and bile.Fórmula:C27H48O4Cor e Forma:SolidPeso molecular:436.67TGR5 Receptor Agonist 3
CAS:TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.Fórmula:C29H27N3O6Cor e Forma:SolidPeso molecular:513.54
