Receptor OX
Os receptores de orexina (OX1 e OX2) são GPCRs que se ligam às orexinas, neuropeptídeos envolvidos na regulação da vigília, apetite e homeostase energética. A desregulação da sinalização da orexina está ligada a distúrbios do sono, como a narcolepsia, bem como a condições metabólicas, como a obesidade. Moduladores dos receptores de orexina estão sendo investigados por seu potencial terapêutico no tratamento de distúrbios do sono, ansiedade e dependência. Na CymitQuimica, oferecemos uma gama de moduladores de receptores de orexina de alta qualidade para apoiar sua pesquisa em biologia do sono, metabolismo e neurofarmacologia.
Foram encontrados 40 produtos de "Receptor OX"
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SB-649868
CAS:<p>SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).</p>Fórmula:C26H24FN3O3SPureza:99.53%Cor e Forma:SolidPeso molecular:477.55Orexin 2 Receptor Agonist
CAS:Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.Fórmula:C32H34N4O5SPureza:98.26% - 99.43%Cor e Forma:SolidPeso molecular:586.7MK-1064
CAS:<p>MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).</p>Fórmula:C24H20ClN5O3Pureza:99.19% - 99.82%Cor e Forma:SolidPeso molecular:461.9DORA-22
CAS:<p>DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory</p>Fórmula:C23H22F2N4O2Pureza:97.67%Cor e Forma:SolidPeso molecular:424.44IPSU
CAS:<p>IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.</p>Fórmula:C23H27N5O2Pureza:97.05%Cor e Forma:SolidPeso molecular:405.49PF3274167
CAS:PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.Fórmula:C19H19ClFN5O3Pureza:99.67% - 99.88%Cor e Forma:SolidPeso molecular:419.84SB-334867 free base
CAS:<p>SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.</p>Fórmula:C17H13N5O2Pureza:99.67% - >99.99%Cor e Forma:SolidPeso molecular:319.32MK-3697
CAS:<p>MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).</p>Fórmula:C23H21N5O3SPureza:97.69% - 98.15%Cor e Forma:SolidPeso molecular:447.51TCS-OX2-29
CAS:<p>TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.</p>Fórmula:C23H31N3O3Pureza:99.81%Cor e Forma:SolidPeso molecular:397.51Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Fórmula:C128H219N45O36SPureza:94.61%Cor e Forma:SolidPeso molecular:2996.45TCS 1102
CAS:<p>TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).</p>Fórmula:C27H26N4O2SPureza:99.35% - 99.52%Cor e Forma:SolidPeso molecular:470.59L-368,899 hydrochloride
CAS:<p>L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.</p>Fórmula:C26H43ClN4O5S2Pureza:99.59%Cor e Forma:SolidPeso molecular:591.23ACT-462206
CAS:<p>ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.</p>Fórmula:C20H24N2O4SPureza:99.45%Cor e Forma:SolidPeso molecular:388.48Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Fórmula:C23H16D2F4N4O2Pureza:98.89%Cor e Forma:SolidPeso molecular:460.42Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749(S)-YNT-3708
CAS:<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392RTIOXA-43
CAS:<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Fórmula:C37H37N5O5SPureza:99.17%Cor e Forma:SolidPeso molecular:663.79CVN766
CAS:<p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>Fórmula:C20H21F3N8OCor e Forma:SolidPeso molecular:446.43
