Receptor OX
Os receptores de orexina (OX1 e OX2) são GPCRs que se ligam às orexinas, neuropeptídeos envolvidos na regulação da vigília, apetite e homeostase energética. A desregulação da sinalização da orexina está ligada a distúrbios do sono, como a narcolepsia, bem como a condições metabólicas, como a obesidade. Moduladores dos receptores de orexina estão sendo investigados por seu potencial terapêutico no tratamento de distúrbios do sono, ansiedade e dependência. Na CymitQuimica, oferecemos uma gama de moduladores de receptores de orexina de alta qualidade para apoiar sua pesquisa em biologia do sono, metabolismo e neurofarmacologia.
Foram encontrados 54 produtos para "Receptor OX".
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ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Fórmula:C20H24N2O4SPureza:99.87%Cor e Forma:SolidPeso molecular:388.48Ref: TM-T26559
1mg42,00€1mL*10mM (DMSO)87,00€5mg88,00€10mg130,00€25mg264,00€50mg423,00€100mg670,00€500mg1.341,00€L-368,899 hydrochloride
CAS:L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.Fórmula:C26H43ClN4O5S2Pureza:99.68%Cor e Forma:SolidPeso molecular:591.23Ref: TM-T11794
2mg105,00€5mg147,00€1mL*10mM (DMSO)178,00€10mg230,00€25mg439,00€50mg685,00€100mg964,00€GSK1059865
CAS:GSK1059865 is a potent antagonist of the orexin 1 receptor.Fórmula:C20H23BrFN3O2Pureza:99.72%Cor e Forma:SolidPeso molecular:436.32Ref: TM-T11477
1mg69,00€5mg147,00€1mL*10mM (DMSO)164,00€10mg230,00€25mg386,00€50mg582,00€100mg873,00€OX2R agonist 1
CAS:OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Fórmula:C21H28F2N2O5SCor e Forma:SolidPeso molecular:458.52OX2R-IN-3
CAS:OX2R-IN-3 (Compound 53) functions as an orally active agonist for the type 2 orexin receptor (OX2R), exhibiting an EC50 value of less than 100 nM [1].Fórmula:C24H30F3N3O3SPeso molecular:497.57RTIOXA-43
CAS:RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Fórmula:C37H37N5O5SPureza:99.17%Cor e Forma:White SolidPeso molecular:663.79Ref: TM-T87345
10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg193,00€5mg485,00€1mL*10mM (DMSO)707,00€Rocavorexant
CAS:Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Fórmula:C18H19F3N8OCor e Forma:SolidPeso molecular:420.392(S)-YNT-3708
CAS:(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749YNT-3708
CAS:YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.Fórmula:C35H36N4O6SCor e Forma:SolidPeso molecular:640.749Alixorexton
CAS:Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.Fórmula:C21H30N2O5SCor e Forma:SolidPeso molecular:422.538Tebideutorexant
CAS:Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.Fórmula:C23H16D2F4N4O2Pureza:98.89%Cor e Forma:White SolidPeso molecular:460.42CVN766
CAS:CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Fórmula:C20H21F3N8OCor e Forma:SolidPeso molecular:446.43Orexin receptor antagonist 6
CAS:Orexin Receptor Antagonist 6 (Compound 72) is a selective antagonist of the orexin 1 receptor (OX1), with a Ke value of 8.5 nM and over 1180-fold selectivity over OX2. This compound does not trigger conditioned place preference (CPP) or aversion effects and is capable of inhibiting the formation of cocaine-induced CPP. It is applicable in the research of neurological disorders.Fórmula:C29H32F3N3O5Peso molecular:559.59Fumiporexant
CAS:Fumiporexant (Compound Example 93) is an orally active, brain-penetrant, and selective antagonist of orexin receptor 2 (OX2R). It regulates the sleep-wake cycle and pathways related to mood in the central nervous system. Fumiporexant holds potential for research into neurological disorders such as insomnia and major depressive disorder.Fórmula:C24H24F2N6O2Peso molecular:466.48
