Hedgehog/Smoothened
A via de sinalização Hedgehog/Smoothened é uma via crucial relacionada aos GPCRs, envolvida no desenvolvimento embrionário, regeneração de tecidos e manutenção de células-tronco. Smoothened (SMO) é uma proteína transmembrana chave que transduz sinais dos ligantes Hedgehog (Hh) para ativar cascatas de sinalização a jusante. A desregulação da via Hedgehog/Smoothened está implicada em vários tipos de câncer e distúrbios do desenvolvimento, tornando-a um alvo significativo para intervenção terapêutica. Na CymitQuimica, oferecemos uma gama de moduladores de alta qualidade para a via Hedgehog/Smoothened para apoiar sua pesquisa em biologia do desenvolvimento, oncologia e medicina regenerativa.
Foram encontrados 49 produtos de "Hedgehog/Smoothened"
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GANT 58
CAS:GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Fórmula:C24H16N4SPureza:99.53%Cor e Forma:SolidPeso molecular:392.48ALLO-2
CAS:ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Fórmula:C18H12F3N5OPureza:99.19%Cor e Forma:SolidPeso molecular:371.32Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Fórmula:C22H23F2N3O2SPureza:99.64%Cor e Forma:SolidPeso molecular:431.5HPP-9
HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BETFórmula:C49H52N6O11Cor e Forma:SolidPeso molecular:900.97SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Fórmula:C28H30Cl3N3OSPureza:>99.99%Cor e Forma:SoildPeso molecular:562.98HSP70-IN-3
HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.Fórmula:C48H78N6O7SCor e Forma:SolidPeso molecular:883.23GI-560192
CAS:GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Fórmula:C20H16N2O2Pureza:99.53%Cor e Forma:SoildPeso molecular:316.35CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Fórmula:C31H43ClN4O5Pureza:94.05%Cor e Forma:SolidPeso molecular:587.15WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Fórmula:C19H17ClN2O2S2Pureza:97.92%Cor e Forma:SolidPeso molecular:404.93HL2-m5
CAS:HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.Fórmula:C70H101N15O24S3Cor e Forma:SolidPeso molecular:1632.83GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Cor e Forma:Odour SolidSANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Fórmula:C26H26ClN3O4Pureza:99.23%Cor e Forma:SolidPeso molecular:479.96JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Fórmula:C19H18N4OSPureza:98.93% - 99.89%Cor e Forma:SolidPeso molecular:350.44MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Fórmula:C31H29N3O5SPureza:99.72%Cor e Forma:SolidPeso molecular:555.64SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Fórmula:C28H28ClN3OSPureza:97.37% - 98.88%Cor e Forma:SolidPeso molecular:490.06SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Fórmula:C28H29Cl2N3OSPureza:99.19% - 99.97%Cor e Forma:SolidPeso molecular:526.52Glasdegib
CAS:Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Fórmula:C21H22N6OPureza:98.72%Cor e Forma:SolidPeso molecular:374.44MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Fórmula:C24H23N3O5SPureza:99.73%Cor e Forma:SolidPeso molecular:465.52HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Fórmula:C27H29NO6Pureza:97.6%Cor e Forma:SolidPeso molecular:463.52HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFórmula:C24H23ClN4O3Pureza:95.73%Cor e Forma:SolidPeso molecular:450.92
