DHFR

P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.

Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide.

Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.

Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).

<p>Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.</p>

Compound PDK0318, with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0318 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.

<p>DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.</p>

<p>DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.</p>

<p>EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.</p>

DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.

<p>EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.</p>

CB 3705 is a bio-active chemical.

DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.

Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.

WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.

WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.

DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.

Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.

<p>Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.</p>