DHFR

P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.

DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.

DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.

4-O-Methyldopamine hydrochloride ,with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-O-Methyldopamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

CB 3705 is a bio-active chemical.

EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.

DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.

EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.

TH9028 TFA is an effective MTHFD2 inhibitor (IC50=11 nM) that suppresses proliferation in HL-60 cells, AML cells, and T-ALL Jurkat cells.

DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.

DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.

Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.

DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.

WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.

WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.

Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.

Key enzyme in folate metabolism.

Key enzyme in folate metabolism.

Key enzyme in folate metabolism.