Síntese de DNA/RNA
Os inibidores da síntese de DNA e RNA são compostos que interferem nos processos de replicação e transcrição nas células, impedindo a produção de material genético essencial. Esses inibidores podem atingir várias enzimas e proteínas envolvidas na síntese de ácidos nucleicos, tornando-os ferramentas valiosas para estudar os mecanismos de replicação, transcrição e tradução. Eles também são usados no desenvolvimento de tratamentos para infecções e câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores da síntese de DNA/RNA para apoiar sua pesquisa em biologia molecular, virologia e desenvolvimento terapêutico.
Foram encontrados 793 produtos de "Síntese de DNA/RNA"
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DMT-dG(ib) Phosphoramidite
CAS:<p>DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.</p>Fórmula:C44H54N7O8PPureza:99.21%Cor e Forma:SolidPeso molecular:839.92EFdA-TP
CAS:EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.Fórmula:C12H15FN5O12P3Cor e Forma:SolidPeso molecular:533.195Ribonuclease T1
CAS:<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Cor e Forma:Solid2'-Deoxy-2'-fluoro-l-uridine
CAS:2'-Deoxy-2'-fluoro-1-uridine: an L-nucleoside, inhibits RNA viruses by blocking viral RNA polymerase.Fórmula:C9H11FN2O5Cor e Forma:SolidPeso molecular:246.19Polynucleotide kinase
CAS:Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end<sup></sup>.Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Fórmula:C27H23ClF2N4O2Cor e Forma:SolidPeso molecular:508.947ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Cor e Forma:SolidPeso molecular:713.582'-OMe-Ac-C Phosphoramidite
CAS:2'-OMe-Ac-C Phosphoramidite, a modified phosphoramidite, is utilized in the synthesis of oligonucleotides.Fórmula:C42H52N5O9PCor e Forma:SolidPeso molecular:801.86Xanthosine-5'-Triphosphate
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Fórmula:C10H15N4O15P3Cor e Forma:SolidPeso molecular:524.164N7-Methyl-guanosine-5'-triphosphate-5'-adenosine diammonium
CAS:<p>N7-Methylguanosine-5'-triphosphate-5'-adenosine (m7GpppA) diammonium, a dinucleotide cap analog, facilitates in vitro RNA transcription [1].</p>Fórmula:C21H35N12O17P3Cor e Forma:SolidPeso molecular:820.49WRN inhibitor 16
WRN inhibitor 16 (Example 83) is an orally active WRN inhibitor. In a SW48 xenograft mouse tumor model, WRN inhibitor 16 did not cause tumor regression.Fórmula:C31H30F4N4O5SCor e Forma:SolidPeso molecular:646.652'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.Fórmula:C10H14N5Na2O8PCor e Forma:SolidPeso molecular:409.202WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.Fórmula:C35H40F4N10O5Cor e Forma:SolidPeso molecular:756.75wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Cor e Forma:Odour SolidIBU-DC Phosphoramidite
CAS:IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.Fórmula:C43H54N5O8PCor e Forma:SolidPeso molecular:799.906RNA splicing modulator 3
CAS:RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSCor e Forma:SolidPeso molecular:380.47Demycarosyl-3D-β-D-digitoxosylmithramycin SK
CAS:Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.Fórmula:C50H72O23Cor e Forma:SolidPeso molecular:1041.09TAC
CAS:TAC is a TERT (telomerase reverse transcriptase) activator, promotes telomere synthesis, reduces cellular senescence and inflammatory cytokinesFórmula:C14H12ClF2NO2SPureza:99.20%Cor e Forma:SolidPeso molecular:331.77NUDT5/14 antagonist 1
NUDT5/14 antagonist 1 (Compound 9) is a dual selective antagonist for nucleotide diphosphate kinases NUDT5 and NUDT14, exhibiting IC50 values of 0.27 and 0.16 μM, respectively. Additionally, NUDT5/14 antagonist 1 binds to Bruton's tyrosine kinase (BTK) with an IC50 of 0.377 μM.Fórmula:C23H24N6OPeso molecular:400.20116T7 RNA polymerase
CAS:T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcriptionPureza:98%Cor e Forma:Solid
