HIV Protease
Os inibidores da protease do HIV são uma classe de medicamentos antirretrovirais que têm como alvo específico a enzima protease do vírus da imunodeficiência humana (HIV). Ao inibir esta enzima, esses compostos impedem o vírus de processar suas poliproteínas em proteínas maduras e funcionais, bloqueando assim a produção de novos virions infecciosos. Os inibidores da protease do HIV são um pilar da terapia antirretroviral altamente ativa (HAART) utilizada para o tratamento do HIV/AIDS. Na CymitQuimica, oferecemos uma variedade de inibidores da protease do HIV para apoiar sua pesquisa em tratamento do HIV, resistência a medicamentos e virologia.
Foram encontrados 502 produtos de "HIV Protease"
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HIV-1 inhibitor-8
HIV-1 inhibitor-8: potent oral NNRTI, low toxicity, IC50: 0.081 μM, effective on multiple strains, EC50: 4.44-54.5 nM.Fórmula:C25H21N5OSCor e Forma:SolidPeso molecular:439.53HIV-1 inhibitor-44
HIV-1 inhibitor-44 (compound 11l) is an HIV-1 reverse transcriptase inhibitor that exhibits activity against wild-type HIV-1 strains (EC50: 0.209 μM).Fórmula:C23H26N2O4SCor e Forma:SolidPeso molecular:426.53HIV-1 inhibitor-17
HIV-1 inhibitor-18 blocks HIV-1 capsid, acts on NL4-3 strain (EC50: 2.57 μM), has low cytotoxicity (MT-4 CC50: >8.55).Fórmula:C32H32N4O5SCor e Forma:SolidPeso molecular:584.69Emtricitabine triphosphate
CAS:Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.Fórmula:C8H13FN3O12P3SCor e Forma:SolidPeso molecular:487.19BRN3OMe
CAS:<p>BRN3OMe is an effective inhibitor of HIV-1 reverse transcriptase (HIV-1 reverse transcriptase), showing potential for antiviral drug research.</p>Fórmula:C7H13N3O4Cor e Forma:SolidPeso molecular:203.196Methyl piperazine-2-carboxylate
CAS:Methyl piperazine-2-carboxylate (compound 4) is a potent activator of METTL3/METTL14/WTAP. It enhances the production of HIV-1p24 viral particles and increases the level of N6-methyladenosine in the viral RNA genome.Fórmula:C6H12N2O2Cor e Forma:SolidPeso molecular:144.172NBD-14189
CAS:NBD-14189: Potent HIV-1 entry blocker, binds gp120, IC50: 89 nM, strong antiviral (EC50 <200 nM).Fórmula:C18H16F4N4O2SCor e Forma:SolidPeso molecular:428.40BI 224436
CAS:BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.Fórmula:C27H26N2O4Cor e Forma:SolidPeso molecular:442.51BRD-K98645985
CAS:BRD-K98645985: BAF inhibitor, binds ARID1A, reverses HIV-1 latency, EC50 ~2.37μM, alters nucleosome placement.Fórmula:C33H43N5O4Pureza:98%Cor e Forma:SolidPeso molecular:573.73Integrase-LEDGF/p75 allosteric inhibitor 1
CAS:Oral HIV-1 allosteric integrase inhibitor, blocks DNA integration, antiviral, potent against NL432 (EC50: 3.9 nM).Fórmula:C33H41NO6SCor e Forma:SolidPeso molecular:579.75L-697639
CAS:L-697639 inhibits of HIV-1 reverse transcriptase and HIV-1 replication.Fórmula:C18H21N3O2Cor e Forma:SolidPeso molecular:311.38HIV-1 inhibitor-82
CAS:HIV-1inhibitor-82 (Compound L14) is a small molecule inhibitor of HIV-1 entry with oral bioavailability, exhibiting an IC50 value of 0.39 μM. It holds potential for research in combating HIV-1 infection.Fórmula:C37H37ClN2O6S2Peso molecular:705.28GSK3739936
CAS:<p>GSK3739936 inhibits HIV-1 integrase (IC50: 11.1 nM, EC50: 1.7 nM), weak on CYP (IC50 >24.3 μM), rapid absorption, moderate clearance, high oral availability.</p>Fórmula:C34H43FN2O4Cor e Forma:SolidPeso molecular:562.71MIV-150
CAS:MIV-150 is a nonnucleoside inhibitor of reverse transcriptase (NNRT). MIV-150 also blocking HIV-1 and HIV-2 infections (EC50<1 nM against HIV-1/HIV-2MN).Fórmula:C19H17FN4O3Pureza:98%Cor e Forma:SolidPeso molecular:368.36PD 134922
CAS:PD 134922 is a HIV-1 protease inhibitors. Inactivation of the protease prevents infectious virion formation.Fórmula:C37H61N5O7SPureza:98%Cor e Forma:SolidPeso molecular:719.97DPC 684
CAS:DPC 684 is a potent and selective HIV-1 protease inhibitor with an IC90 of 5.7-40 nM and a Ki of 0.021 nM. It competitively inhibits HIV-1 protease, preventing viral polyprotein cleavage. Compared to cellular proteases, DPC 684 shows high selectivity for retroviral proteases. The compound exhibits low protein binding and offers broad-spectrum inhibition against various wild-type and mutant HIV-1 proteases, with an IC90 of 1.9-6.3 nM. DPC 684 is significant for HIV research.Fórmula:C35H48FN5O5SCor e Forma:SolidPeso molecular:669.85HIV-1-IN-86
CAS:HIV-1-IN-86 (compound 6m) is an HIV-1 inhibitor with an EC50 of 0.77 μM, exhibiting antiviral activity.Fórmula:C20H17N3O7SCor e Forma:SolidPeso molecular:443.43BMS-378806
<p>BMS-378806 is an HIV inhibitor with EC50: 0.85-26.5nM for various strains.</p>Fórmula:C22H22N4O4Pureza:98%Cor e Forma:SolidPeso molecular:406.433-Deazaadenosine
CAS:3-Deazaadenosine, an inhibitor of S-adenosylhomocysteine hydrolase with a Ki of 3.9 μM, exhibits anti-inflammatory, anti-proliferative, and anti-HIV activity.Fórmula:C11H14N4O4Pureza:98%Cor e Forma:SolidPeso molecular:266.25Aurothioglucose
CAS:Aurothioglucose is a active-site TrxR1 inhibitor.Fórmula:C6H11AuO5SPureza:98%Cor e Forma:Yellow Crystals SolidPeso molecular:392.18
