Antibacteriano

<p>Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.</p>

<p>EDA-DA is a probe for labeling bacterial cell wall Peptidoglycan, crucial for division and shape.</p>

<p>2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease.</p>

<p>Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins.</p>

<p>Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.</p>

<p>Altromycin G is a new pluramycin-like antibiotic.</p>

<p>Actinoidin A is a glycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Albothricin is a streptothricin antibiotic.</p>

<p>PF 5081090 has a wide range of applications in life science related research.</p>

<p>Julifloricine is an alkaloid isolated from Prosopis juliflora that has antimicrobial activity.</p>

<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>

<p>Napyradiomycin A1, a fungal compound from C. rubra, has antimicrobial effects (MIC 1.56-12.5 μg/ml) and blocks estrogen receptors and mitochondrial enzymes.</p>

<p>Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.</p>

<p>KPC-2-IN-1, a boronic acid KPC-2 inhibitor (Ki 0.032 μM), boosts cefotaxime against KPC-2 E. coli; tolerable in HEK-293 cells.</p>

<p>8-Methylsulfinyloctyl isothiocyanate: antimicrobial, inhibits plant growth, impairs COX-2 inflammation in macrophages.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>Cephalexin: potent oral antibiotic, broad-spectrum against gram-positive/negative bacteria; treats pneumonia, strep throat, endocarditis.</p>

<p>Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting</p>

<p>Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, demonstrates a high efficacy against S.</p>

<p>Antibacterial agent 163 (compound 1), a hydroxyquinoline derivative, potently inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1].</p>

<p>Arylomycin A4 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>c-di-AMP sodium: STING agonist, activates TBK3-IRF3 pathway, boosts type I IFN/TNF, regulates bacterial growth/virulence, and stimulates immune responses.</p>

<p>Myristoyl glutamic acid sodium, a surfactant in amino acid cleansers, has mild antibacterial properties and cleanses the skin surface of excess oil and dirt.</p>

<p>Antibacterial agent 32 fights E. coli (NCTC 13351, M 50, 7 MP) with MICs: 1, 2, 8 mcg/mL.</p>

<p>PBP4-IN-1 (Compound 1) is an inhibitor targeting penicillin-binding protein 4 (PBP4) in Staphylococcus aureus. By inhibiting the function of PBP4, PBP4-IN-1 enhances the antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) mediated by PBP2a. This compound is used in studies involving osteomyelitis caused by Staphylococcus aureus and in research aimed at reversing PBP4-mediated resistance to β-lactam antibiotics.</p>

<p>Reveromycin D, from Streptomyces, blocks EGF in Balb/MK, halts KB/K562 growth, and shows pH-sensitive antifungal traits.</p>

<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>

<p>Maximin 5, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Betonicine, an l-alpha-amino acid, is in herbs, spices, pulses, and mainly urine.</p>

<p>Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.</p>

<p>Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A.</p>

<p>Aurein 3.2 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>T3SS-IN-3 (compound F-24) serves as an inhibitor specific to the type III secretion system (T3SS), significantly reducing the transcription of the hrpY gene</p>

<p>A-54556B: Natural ADEP antibiotic from S. hawaiiensis, combats Gram-positive and anaerobic bacteria, including penicillin-resistant S. aureus.</p>

<p>T3SS-IN-1 (compound B9) is a potent type III secretion system (T3SS) inhibitor that also suppresses hpa1 promoter activity and harpin protein expression,</p>

<p>Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.</p>

<p>DS86760016 inhibits LeuRS; potent against MDR Gram-negative bacteria; IC50: E. coli 0.38μM, P. aeruginosa 0.62μM, A. baumannii 0.16μM.</p>

<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>

<p>MRV03-070, acting as a biosynthetic precursor akin to precolibactin [1], is a colibactin-activating peptidase ClbP inhibitor with an inhibitory concentration (</p>

<p>Cethromycin (ABT-773) is an antibiotic of ketolide.</p>

<p>Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.</p>

<p>XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.</p>

<p>Aurein 5.2 is an antibiotic antimicrobial peptide [1].</p>

<p>Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).</p>

<p>Vitamin K5, a photosensitizer &amp; antimicrobial, inhibits PKM2, PKM1 &amp; PKL, induces apoptosis in colon cells, and preserves food &amp; medicine.</p>

<p>Linearmycin A, a polyene antibiotic from Streptomyces, fights S. aureus, E. coli, S. cerevisiae, C. albicans, and A. niger with low MICs.</p>

<p>Amustaline (S-303) dihydrochloride is a nucleic acid alkylator useful for inactivating pathogens in blood with red cells.</p>

<p>Cefotetan Sodium: a 2nd-gen cephamycin antibiotic effective against various aerobic/anaerobic, gram+/- bacteria, inhibits cell wall synthesis.</p>

<p>A 201A is a nucleoside antibiotic, it is isolated from Streptomyces capreolus.</p>

<p>Cefozopran is a fourth-generation cephalosporin.</p>

<p>Ga(III)protoporphyrin-IX: soluble in MeOH, mimics malaria pigment, has strong antibacterial properties.</p>

<p>Amythiamicin C is an antimicrobial antibiotic effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and also exhibits activity against Plasmodium falciparum (the causative agent of malaria).</p>

<p>Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.</p>

<p>Tylosin lactate: a vet macrolide antibiotic; broad vs. Gram-positive, limited on Gram-negative; from Streptomyces fradiae.</p>

<p>Alamethicin F50, a 20-amino acid peptaibol from Trichoderma, forms ion channels and has lytic and antibacterial properties.</p>

<p>A unique collection of xnum anti-infective compounds including anti-bacterial, anti-fungi, anti-Human Cytomegalovirus (HCMV), anti-HIV, anti-SARS, anti-</p>

<p>(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].</p>

<p>Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].</p>

<p>Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.</p>

<p>Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.</p>

<p>Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>17-hydroxy Venturicidin A: Streptomyces-derived macrolide with antibiotic and antifungal properties.</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.</p>

<p>Pazufloxacin (T-3761) is a broad-spectrum fluoroquinolone antibiotic effective against various infections, including strains resistant to other quinolones.</p>

<p>Arylomycin B6 is a lipoglycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>6-C-Methylquercetin-3,4'-dimethyl ether is a flavonol derivative extracted from Bauhinia thonningii Schum leaves, displaying antibacterial effects on Gram-</p>

<p>Pacidamycin I is an antimicrobial nucleoside antibiotics. Pacidamycin I inhibits translocase I, a key enzyme in peptidoglycan assembly.</p>

<p>Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Tuberculosis inhibitor 9 (compound 3d), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against Mycobacterium tuberculosis and</p>

<p>Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.</p>

<p>Cis-β-Terpineol, a monoterpene derived from the aerial parts of Anthemis turcomanica, exhibits antibacterial activity as evidenced by studies on the stems,</p>

<p>D13-9001, an antibiotic, inhibits AcrB and MexB with KDs of 1.15μM in E. coli and 3.57μM in P. aeruginosa.</p>

<p>Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.</p>

<p>Dicloxacillin, a β-Lactam antibiotic, targets beta-lactamase bacteria like Staphylococcus aureus, defeating penicillin resistance.</p>

<p>Sirpefenicol (ZTS-00007928), a phenicol antibacterial for treating animal bacterial infections.</p>

<p>Desotamide: an antibiotic cyclic hexapeptide targeting S. aureus, S. pneumoniae, and MRSE with MICs 16, 12.5, 32 μg/ml.</p>

<p>Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].</p>

<p>XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.</p>

<p>Pentalysine is a peptide.</p>

<p>Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>PD 116152: phenazine from Streptomyces with antitumor effects on P388 leukemia (T/C 149) and potent against Streptococcus pneumoniae (MIC &lt; 0.46 µg/ml).</p>

<p>SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.</p>

<p>Compd 3j (Antibacterial agent 149) is a laccase inhibitor that exhibits potent fungicidal activity, particularly useful in researching rice sheath blight [1].</p>

<p>Bryostatin 1, a marine macrolide, permeates CNS and modulates PKC, with strong affinity for Munc13-1 (Ki: 8.07 nM and 0.45 nM).</p>

<p>Quinaldopeptin: a quinomycin antibiotic, combats various bacteria, cytotoxic to cells, aids in P388 leukemia mouse survival, intercalates DNA.</p>

<p>Obtusalin, a triterpenoid initially identified in R. dauricum, exhibits UV absorption at 210 nm and possesses antibacterial properties.</p>

<p>Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory</p>

<p>Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes.</p>

<p>Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.</p>

<p>GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.</p>

<p>Arylomycin A1 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Deacetylnomilin is a useful organic compound for research related to life sciences. The catalog number is T125039 and the CAS number is 3264-90-2.</p>

<p>Chartreusin is an antibiotic. It also has anticancer activity.</p>

<p>Desacetylcefotaxime, a Cefotaxime metabolite, has strong antimicrobial effects against various bacteria.</p>

<p>Altromycin A is an anticancer agent.</p>