AMPK
Os inibidores de AMPK são compostos que inibem a Quinase Ativada por AMP (AMPK), uma enzima que desempenha um papel crucial na homeostase energética celular. A AMPK é ativada em resposta a baixos níveis de energia nas células e ajuda a regular processos como a captação de glicose, a oxidação de ácidos graxos e a biogênese mitocondrial. Inibir a AMPK é importante para estudar seu papel em doenças metabólicas, câncer e envelhecimento. Na CymitQuimica, oferecemos uma gama de inibidores de AMPK para apoiar sua pesquisa em metabolismo, oncologia e doenças relacionadas ao envelhecimento.
Foram encontrados 171 produtos de "AMPK"
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Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Fórmula:C23H30O7Cor e Forma:SolidPeso molecular:418.486TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Fórmula:C21H32O6Pureza:99.21%Cor e Forma:SolidPeso molecular:380.48AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Fórmula:C23H24BrNO2Pureza:99.55%Cor e Forma:SolidPeso molecular:426.35ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Fórmula:C20H25N3O3Pureza:98%Cor e Forma:SolidPeso molecular:355.43ULK1-IN-2
CAS:ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.Fórmula:C19H16BrFN4O6Pureza:99.07% - 99.97%Cor e Forma:SolidPeso molecular:495.26JJO-1
CAS:JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Fórmula:C19H13N3Cor e Forma:SolidPeso molecular:283.33AMPK activator 8
CAS:AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Fórmula:C25H21ClN2O6Cor e Forma:SolidPeso molecular:480.9PF-07899895
CAS:PF-07899895 is an inhibitor of SIK. The IC50 values for SIK1, SIK2 and SIK3 are 1.2 nM, 0.9 nM and 1.8 nM respectively.Fórmula:C23H23N5OSPeso molecular:417.53SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Cor e Forma:SolidPeso molecular:718.02IND 1316
CAS:IND 1316 is an activator of AMP-activated protein kinase (AMPK).Fórmula:C22H17NO3Cor e Forma:SolidPeso molecular:343.38AMDE-1
CAS:<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Fórmula:C18H8ClF6N3Pureza:90%Cor e Forma:SolidPeso molecular:415.72OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Fórmula:C25H24F3N3O6S2Cor e Forma:SolidPeso molecular:583.6AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Fórmula:C24H21ClN2O3Pureza:99.97% - 99.99%Cor e Forma:SolidPeso molecular:420.89AMPK activator 1
CAS:AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Fórmula:C32H33F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:578.62GL-V9
CAS:GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Fórmula:C24H27NO5Cor e Forma:SolidPeso molecular:409.47Galegine hydrochloride
CAS:Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Fórmula:C6H14ClN3Cor e Forma:SolidPeso molecular:163.65HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Fórmula:C13H17ClF3N5OPureza:98%Cor e Forma:SolidPeso molecular:351.76LRRK2/NUAK1/TYK2-IN-1
CAS:LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Fórmula:C20H11F3N6Cor e Forma:SolidPeso molecular:392.34MARK-IN-4
CAS:MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.Fórmula:C21H23N7OSCor e Forma:SolidPeso molecular:421.52
