Sinalização PI3K/Akt/mTOR
Os inibidores da sinalização PI3K/Akt/mTOR são compostos que têm como alvo as vias da fosfoinositídeo 3-quinase (PI3K), da quinase Akt e do alvo da rapamicina em mamíferos (mTOR). Essas vias são reguladores críticos do crescimento celular, sobrevivência, metabolismo e autofagia, tornando-os alvos-chave na pesquisa de câncer e distúrbios metabólicos. A inibição dessas vias pode ajudar a controlar o crescimento e a proliferação tumoral, oferecendo estratégias terapêuticas potenciais para vários tipos de câncer e outras doenças caracterizadas por sinalização celular desregulada. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de alta qualidade de PI3K/Akt/mTOR para apoiar sua pesquisa em oncologia, sinalização celular e doenças metabólicas.
Subcategorias de "Sinalização PI3K/Akt/mTOR"
- AMPK(161 produtos)
- ATM/ATR(72 produtos)
- DNA-PK(50 produtos)
- EGFR(590 produtos)
- MELK(7 produtos)
- PDK(9 produtos)
- PI3K(231 produtos)
- S6 Quinase(5 produtos)
- gsk-3(107 produtos)
- mTOR(163 produtos)
Exibir 2 mais subcategorias
Foram encontrados 997 produtos para "Sinalização PI3K/Akt/mTOR".
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Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)Fórmula:C20H22ClFN6O2Pureza:98.59%Cor e Forma:SolidPeso molecular:432.88Ref: TM-T12367
1mg138,00€5mg289,00€1mL*10mM (DMSO)318,00€10mg434,00€25mg763,00€50mg1.054,00€100mg1.423,00€Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Cor e Forma:White SolidPeso molecular:512.339-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Fórmula:C22H13FN2O5Pureza:99.32%Cor e Forma:SolidPeso molecular:404.35Ref: TM-T14066
1mg50,00€2mg66,00€5mg94,00€1mL*10mM (DMSO)110,00€10mg155,00€25mg309,00€50mg447,00€100mg667,00€Indazole
CAS:Indazole, a heterocyclic compound, offers diverse biological activities.Fórmula:C7H6N2Pureza:99.59% - 99.85%Cor e Forma:White SolidPeso molecular:118.14MELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Fórmula:C31H33N5O4Pureza:99.84%Cor e Forma:SolidPeso molecular:539.62Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity，and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Fórmula:C24H18ClFN4O2Pureza:99.89% - 99.91%Cor e Forma:Yellow SolidPeso molecular:448.88Ref: TM-T14336
1mg50,00€5mg105,00€1mL*10mM (DMSO)128,00€10mg172,00€25mg313,00€50mg467,00€100mg663,00€NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Cor e Forma:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€1mL*10mM (DMSO)84,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€Erlotinib hydrochloride
CAS:Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4·HClPureza:99.78% - 99.97%Cor e Forma:SolidPeso molecular:429.90Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Fórmula:C23H18FN5O2Pureza:99.71%Cor e Forma:SolidPeso molecular:415.42Ref: TM-T13119
1mg35,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg96,00€25mg152,00€50mg236,00€100mg434,00€AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Fórmula:C41H44ClFN6O7S2Pureza:99.85% - 99.92%Cor e Forma:SolidPeso molecular:851.41Ref: TM-T10419
1mg42,00€2mg55,00€5mg90,00€1mL*10mM (DMSO)129,00€10mg137,00€25mg240,00€50mg403,00€100mg582,00€Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Fórmula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPureza:98% - 99.41%Cor e Forma:White SolidPeso molecular:943.47LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Cor e Forma:White SolidPeso molecular:414.48Ref: TM-T15789
5mg43,00€1mL*10mM (DMSO)47,00€10mg71,00€25mg138,00€50mg231,00€100mg344,00€200mg505,00€BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Fórmula:C20H23N3OPureza:99.01%Cor e Forma:SolidPeso molecular:321.42Gefitinib
CAS:Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.Fórmula:C22H24ClFN4O3Pureza:99.92% - >99.99%Cor e Forma:White SolidPeso molecular:446.90Erlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4Pureza:98.19% - 99.98%Cor e Forma:White SolidPeso molecular:393.44O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Fórmula:C21H22ClFN4O3Pureza:97.17%Cor e Forma:White SolidPeso molecular:432.88Petosemtamab
CAS:Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.Pureza:> 95% - > 95%Cor e Forma:Transparent LiquidPeso molecular:145.97 kDaLosatuxizumab
CAS:Losatuxizumab (ABT-806) is an anti-EGFR monoclonal antibody with potential anti-tumor activity for the study of advanced malignant solid tumors.Pureza:97.3% (SDS-PAGE); 95.1% (SEC-HPLC) - 97.3% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:144.85 kDaLapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Fórmula:C29H26ClFN4O4S·2C7H8O3SPureza:99.41%Cor e Forma:White SolidPeso molecular:925.46LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Fórmula:C20H22N4O2Pureza:99.48%Cor e Forma:SolidPeso molecular:350.41
