PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 241 produtos de "PI3K"
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(3S)-GSK-F1
CAS:<p>(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.</p>Fórmula:C27H18F5N5O4SPureza:99.04%Cor e Forma:SoildPeso molecular:603.52ARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Fórmula:C14H13N3O2S2Pureza:99.75%Cor e Forma:SoildPeso molecular:319.40PI3Kα-IN-25
<p>PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.</p>Fórmula:C21H19ClN4O4Cor e Forma:SolidPeso molecular:426.853FD274
CAS:<p>FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,</p>Fórmula:C22H14ClFN6O2SPureza:98%Cor e Forma:SoildPeso molecular:480.9IHMT-PI3Kδ-372 S-isomer
CAS:<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Fórmula:C26H23F2N7O2Pureza:99.97%Cor e Forma:SoildPeso molecular:503.5mTOR inhibitor 9c
CAS:<p>mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.</p>Fórmula:C21H22FN5O2SPureza:99.23%Cor e Forma:SoildPeso molecular:427.5PI5P4Ks-IN-2
CAS:<p>PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.</p>Fórmula:C22H23N5Pureza:98.36% - 99.02%Cor e Forma:SoildPeso molecular:357.45IHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Fórmula:C22H20F2N6O4Cor e Forma:SolidPeso molecular:470.43GSK251
CAS:<p>GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.</p>Fórmula:C29H37FN6O4SPureza:99.8%Cor e Forma:SolidPeso molecular:584.71PI3Kδ-IN-12
<p>PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4</p>Fórmula:C20H15Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:444.27PF-06843195
CAS:<p>PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .</p>Fórmula:C20H25F3N8O4Pureza:98.01%Cor e Forma:SolidPeso molecular:498.46Apitolisib
CAS:<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Cor e Forma:SolidPeso molecular:498.6PIK-108
CAS:<p>PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).</p>Fórmula:C22H24N2O3Pureza:98.92%Cor e Forma:SolidPeso molecular:364.44PIK-75 hydrochloride
CAS:<p>PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.</p>Fórmula:C16H14BrN5O4S·HClPureza:97.82%Cor e Forma:SolidPeso molecular:488.74YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Fórmula:C20H20BrNO2Pureza:99.65%Cor e Forma:SolidPeso molecular:386.28Brevianamide F
CAS:<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Fórmula:C16H17N3O2Pureza:97.30% - 98.82%Cor e Forma:SolidPeso molecular:283.33Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Fórmula:C19H22F3N5O2SPureza:98% - 99.73%Cor e Forma:SolidPeso molecular:441.47Glaucocalyxin A
CAS:<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Fórmula:C20H28O4Pureza:99.55% - 99.80%Cor e Forma:SolidPeso molecular:332.43Rigosertib
CAS:<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Fórmula:C21H25NO8SPureza:99.53%Cor e Forma:SolidPeso molecular:451.49NIBR-17
CAS:<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Fórmula:C18H20N8O2Pureza:97.79%Cor e Forma:SolidPeso molecular:380.4
