PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos de "PI3K"
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Sophocarpine monohydrate
CAS:Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Fórmula:C15H22N2OPureza:99.55%Cor e Forma:SolidPeso molecular:246.35NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Cor e Forma:SolidPeso molecular:627.68Ref: TM-T16355
2mg39,00€5mg60,00€1mL*10mM (DMSO)84,00€10mg87,00€25mg159,00€50mg231,00€100mg355,00€200mg505,00€Copanlisib dihydrochloride
CAS:Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.Fórmula:C23H30Cl2N8O4Pureza:99.05% - 99.16%Cor e Forma:SolidPeso molecular:553.44Inavolisib
CAS:Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.Fórmula:C18H19F2N5O4Pureza:97.36% - 99.90%Cor e Forma:SolidPeso molecular:407.37Ref: TM-T15375
1mg88,00€5mg212,00€10mg373,00€1mL*10mM (DMSO)404,00€25mg635,00€50mg1.035,00€100mg1.691,00€200mg2.262,00€Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Fórmula:C21H27ClN2S2Pureza:99.55% - 99.957%Cor e Forma:White To Off-White SolidPeso molecular:407.04CGS 15943
CAS:CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Fórmula:C13H8ClN5OPureza:97.4%Cor e Forma:SolidPeso molecular:285.69Ref: TM-T14944
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg82,00€25mg147,00€50mg222,00€100mg334,00€200mg494,00€Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Fórmula:C20H22ClFN6O2Pureza:98.59%Cor e Forma:SolidPeso molecular:432.88Recilisib
CAS:Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.Fórmula:C16H13ClO4SPureza:98.85% - 98.96%Cor e Forma:SolidPeso molecular:336.79Ref: TM-T13862
1mg43,00€2mg56,00€5mg93,00€1mL*10mM (DMSO)100,00€10mg113,00€25mg177,00€50mg295,00€100mg477,00€200mg677,00€Pictilisib dimethanesulfonate
CAS:Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) andFórmula:C25H35N7O9S4Pureza:99.63%Cor e Forma:SolidPeso molecular:705.85Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Fórmula:C23H18FN5O2Pureza:99.71%Cor e Forma:SolidPeso molecular:415.42Ref: TM-T13119
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg178,00€50mg289,00€100mg434,00€P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Fórmula:C31H40N8O3SPureza:99.75%Cor e Forma:SolidPeso molecular:604.77IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Fórmula:C25H25N7O2Pureza:98.00%Cor e Forma:SolidPeso molecular:455.51Ref: TM-T15592
1mg44,00€2mg60,00€5mg99,00€1mL*10mM (DMSO)107,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€PI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Fórmula:C23H25N3O5S2Pureza:97.18%Cor e Forma:SolidPeso molecular:487.59Ref: TM-T12469
1mg75,00€5mg178,00€1mL*10mM (DMSO)197,00€10mg268,00€25mg485,00€50mg677,00€100mg888,00€Safingol hydrochloride
CAS:Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Fórmula:C18H40ClNO2Pureza:99.39% - 99.71%Cor e Forma:SoildPeso molecular:337.969PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Fórmula:C22H25N3O5S2Pureza:99.76%Cor e Forma:SolidPeso molecular:475.58Ref: TM-T12468
1mg75,00€5mg156,00€1mL*10mM (DMSO)164,00€10mg241,00€25mg399,00€50mg532,00€100mg750,00€200mg1.009,00€D-106669
CAS:D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Fórmula:C17H18N6OCor e Forma:SolidPeso molecular:322.36PI3K-IN-41
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV lightFórmula:C45H39F2N5O12SPureza:98%Cor e Forma:SolidPeso molecular:911.88GSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.
Fórmula:C25H30N6O7SPureza:99.52%Cor e Forma:SoildPeso molecular:558.61PITCOIN4
PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivityPureza:98%Cor e Forma:Odour SolidPI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Fórmula:C50H46F4N8O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1027.07IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFórmula:C26H21F2N7O3Pureza:98%Cor e Forma:SolidPeso molecular:517.49GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Fórmula:C29H37FN6O4SPureza:99.8%Cor e Forma:SolidPeso molecular:584.71PI5P4Ks-IN-2
CAS:PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.Fórmula:C22H23N5Pureza:98.97% - 99.35%Cor e Forma:SoildPeso molecular:357.45Ref: TM-T72032
1mg152,00€5mg319,00€1mL*10mM (DMSO)350,00€10mg477,00€25mg803,00€50mg1.054,00€100mg1.378,00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Fórmula:C20H15Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:444.27PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain ofFórmula:C26H20ClFN8OPureza:98%Cor e Forma:SolidPeso molecular:514.94PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Pureza:98%Cor e Forma:Odour SolidDuvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Fórmula:C22H18Cl2N6OPureza:99.86% - 99.88%Cor e Forma:SoildPeso molecular:453.32Ref: TM-T11129L
1mg296,00€5mg718,00€1mL*10mM (DMSO)895,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€PI3K-IN-46
CAS:PI3K-IN-46 is a specific inhibitor of PI3Kγ.Fórmula:C13H9N3OSPureza:97.26%Cor e Forma:SoildPeso molecular:255.3Ref: TM-T64392
1mg62,00€1mL*10mM (DMSO)133,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€PI3Kα-IN-12
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values
Fórmula:C28H36F2N10O5S3Cor e Forma:SolidPeso molecular:726.84STX-478
CAS:STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFórmula:C16H12F5N5O2Pureza:98.31% - 99.78%Cor e Forma:SolidPeso molecular:401.29Ref: TM-T78211
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg286,00€25mg512,00€50mg772,00€100mg1.153,00€740 Y-P(TFA)
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.Fórmula:C143H223F3N43O41PS3Pureza:99.78%Cor e Forma:SolidPeso molecular:3384.73740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Fórmula:C143H226N43O41PS3Pureza:99.92%Cor e Forma:SoildPeso molecular:3330.79Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Fórmula:C31H24F3N5O3Pureza:97.34%Cor e Forma:SolidPeso molecular:571.55Ref: TM-T13140
1mg177,00€5mg432,00€1mL*10mM (DMSO)532,00€10mg620,00€25mg1.108,00€50mg1.431,00€100mg1.783,00€PROTAC PI3K/110β degrader-1
CAS:PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Fórmula:C51H65N9O9SCor e Forma:SolidPeso molecular:980.18PROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Cor e Forma:Odour SolidWYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Fórmula:C28H32N8O3Pureza:99.93%Cor e Forma:SolidPeso molecular:528.61IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Fórmula:C26H23F2N7O2Pureza:99.97%Cor e Forma:SoildPeso molecular:503.5Ref: TM-T60196
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)294,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€BAY1082439
CAS:BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Fórmula:C25H30N6O5Pureza:98%Cor e Forma:SolidPeso molecular:494.54(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Fórmula:C27H18F5N5O4SPureza:99.04%Cor e Forma:SoildPeso molecular:603.52Ref: TM-T67837
1mg70,00€5mg133,00€1mL*10mM (DMSO)182,00€10mg210,00€25mg371,00€50mg532,00€100mg837,00€PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Fórmula:C21H19ClN4O4Cor e Forma:SolidPeso molecular:426.853PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCor e Forma:Odour SolidRef: TM-L1300
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Fórmula:C14H13N3O2S2Pureza:99.75%Cor e Forma:SoildPeso molecular:319.40Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarFDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Cor e Forma:LiquidPI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Cor e Forma:Odour SolidIHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Fórmula:C22H20F2N6O4Cor e Forma:SolidPeso molecular:470.43PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Fórmula:C20H25F3N8O4Pureza:98.01%Cor e Forma:SolidPeso molecular:498.46Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Fórmula:C36H56O13Pureza:99.66% - 99.74%Cor e Forma:SolidPeso molecular:696.82Ref: TM-T5S1982
1mg35,00€5mg77,00€10mg106,00€1mL*10mM (DMSO)107,00€25mg170,00€50mg253,00€100mg375,00€500mg892,00€PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Cor e Forma:SolidPeso molecular:364.44Ref: TM-T28416
1mg40,00€2mg57,00€5mg97,00€1mL*10mM (DMSO)105,00€10mg156,00€25mg255,00€50mg368,00€100mg510,00€200mg700,00€Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Fórmula:C16H17N3O2Pureza:97.30% - 98.82%Cor e Forma:SolidPeso molecular:283.33
