PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos para "PI3K".
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DS-7423
CAS:DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.Fórmula:C22H27F3N10O2Pureza:99.98%Cor e Forma:White SolidPeso molecular:520.51Ref: TM-T36083
1mg110,00€5mg268,00€1mL*10mM (DMSO)304,00€10mg409,00€25mg670,00€50mg888,00€100mg1.305,00€Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFórmula:C32H41N9O4Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:615.73KU-0060648
CAS:KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Fórmula:C33H34N4O4SPureza:98.75%Cor e Forma:SolidPeso molecular:582.71Desmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Fórmula:C16H20N8OPureza:>99.99%Cor e Forma:Yellow SolidPeso molecular:340.38Duvelisib
CAS:Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.Fórmula:C22H17ClN6OPureza:98.87% - 99.74%Cor e Forma:SolidPeso molecular:416.86PIK-75
CAS:PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).Fórmula:C16H14BrN5O4SPureza:98.52% - >99.99%Cor e Forma:Yellow SolidPeso molecular:452.28CZC24832
CAS:CZC24832 is a selective inhibitor of PI 3-kinase γ.Fórmula:C15H17FN6O2SPureza:99.08% - 99.12%Cor e Forma:SolidPeso molecular:364.4Ref: TM-T1949
1mg48,00€2mg63,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg138,00€25mg226,00€50mg338,00€100mg497,00€Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Fórmula:C19H20O6Pureza:99.6% - 99.71%Cor e Forma:White SolidPeso molecular:344.36Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Fórmula:C21H16FN7OPureza:98.99% - ≥95%Cor e Forma:SolidPeso molecular:401.4Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Fórmula:C20H23Cl2FN6O2Pureza:98%Cor e Forma:SolidPeso molecular:469.34GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Cor e Forma:SolidPeso molecular:504.63Ref: TM-T3692
1mg44,00€2mg57,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg138,00€25mg286,00€50mg447,00€100mg677,00€TG 100713
CAS:TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.Fórmula:C12H10N6OPureza:98.17%Cor e Forma:SolidPeso molecular:254.25BEBT-908
CAS:BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Fórmula:C23H25N9O3SPureza:99.67%Cor e Forma:SolidPeso molecular:507.57Ref: TM-T16529
1mg94,00€5mg222,00€1mL*10mM (DMSO)249,00€10mg334,00€25mg562,00€50mg802,00€100mg1.063,00€200mg1.459,00€PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Fórmula:C31H29N5O6SPureza:97.03% - 98%Cor e Forma:SolidPeso molecular:599.661,3-Dicaffeoylquinic acid
CAS:1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.Fórmula:C25H24O12Pureza:98% - 98.81%Cor e Forma:SolidPeso molecular:516.45Ref: TM-T5736
1mg37,00€5mg71,00€10mg90,00€1mL*10mM (DMSO)103,00€25mg147,00€50mg208,00€100mg309,00€200mg447,00€Euscaphic acid
CAS:Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Fórmula:C30H48O5Pureza:98.93%Cor e Forma:White SolidPeso molecular:488.7AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Fórmula:C12H7N3O2SPureza:97% - 99.91%Cor e Forma:Red SolidPeso molecular:257.27HS-173
CAS:HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).Fórmula:C21H18N4O4SPureza:99.33% - 99.64%Cor e Forma:SolidPeso molecular:422.46Ref: TM-T2308
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg128,00€50mg200,00€100mg296,00€200mg425,00€Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Fórmula:C19H17N5O3Pureza:98.41% - 99.5%Cor e Forma:SolidPeso molecular:363.37TG100-115
CAS:TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.Fórmula:C18H14N6O2Pureza:99.22% - 99.26%Cor e Forma:SolidPeso molecular:346.34Ref: TM-T2672
1mg40,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg200,00€50mg358,00€100mg557,00€500mg1.153,00€Sophocarpine
CAS:Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Fórmula:C15H22N2OPureza:99.89%Cor e Forma:SolidPeso molecular:246.35Quercetin Dihydrate
CAS:Quercetin Dihydrate (Sophoretin) is a flavonoid natural product that activates or inhibits the activity of many proteins. It activates SIRT1 and inhibits PI3K.Fórmula:C15H10O7·2H2OPureza:97.77% - 99.79%Cor e Forma:Yellow SolidPeso molecular:338.2725(R,S)-Ruscogenin
CAS:25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.Fórmula:C27H42O4Pureza:99.32% - 99.89%Cor e Forma:White SolidPeso molecular:430.62Buparlisib
CAS:Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).Fórmula:C18H21F3N6O2Pureza:95.32% - 98.45%Cor e Forma:SolidPeso molecular:410.39Ref: TM-T1827
5mg59,00€1mL*10mM (DMSO)65,00€10mg80,00€25mg88,00€50mg109,00€100mg137,00€200mg222,00€500mg403,00€Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Fórmula:C15H10O7Pureza:96.29% - 99.98%Cor e Forma:Yellow SolidPeso molecular:302.24MOMIPP
CAS:MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.Fórmula:C18H16N2O2Pureza:99.66%Cor e Forma:SolidPeso molecular:292.33Ref: TM-T33467
1mg108,00€5mg152,00€1mL*10mM (DMSO)167,00€10mg236,00€25mg432,00€50mg595,00€100mg893,00€(+)-Nortrachelogenin
CAS:(+)-Nortrachelogenin is a lignan isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). (+)-Nortrachelogenin possesses antileukemic activity.Fórmula:C20H22O7Pureza:99.88%Cor e Forma:SolidPeso molecular:374.38Alpelisib hydrochloride
CAS:Alpelisib hydrochloride (BYL-719 HCl) is a potent PI3Kα inhibitor (IC₅₀ = 5 nM) with selectivity and oral bioavailability. Cancer research.Fórmula:C19H23ClF3N5O2SPureza:97.64%Cor e Forma:Yellow SolidPeso molecular:477.93Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Cor e Forma:SolidPeso molecular:406.48740 Y-P
CAS:740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!Fórmula:C141H222N43O39PS3Pureza:98.3% - 99.87%Cor e Forma:White SolidPeso molecular:3270.7RLY-2608
CAS:RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.Fórmula:C29H14ClF5N6O2Pureza:98.62% - 98.7%Cor e Forma:SolidPeso molecular:608.91BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.77%Cor e Forma:SolidPeso molecular:650.6Ref: TM-T6072
1mg35,00€5mg73,00€1mL*10mM (DMSO)94,00€10mg108,00€25mg230,00€50mg339,00€100mg485,00€200mg665,00€Sonolisib
CAS:Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).Fórmula:C29H35NO8Pureza:98%Cor e Forma:SolidPeso molecular:525.59GSK2292767
CAS:GSK2292767 is a potent and selective PI3Kδ inhibitor.Fórmula:C24H28N6O5SPureza:98%Cor e Forma:SolidPeso molecular:512.58CNX-1351
CAS:CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.Fórmula:C30H35N7O3SPureza:99.66% - 99.83%Cor e Forma:White SolidPeso molecular:573.71Nemiralisib
CAS:Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.Fórmula:C26H28N6OPureza:99.91%Cor e Forma:SolidPeso molecular:440.54PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Fórmula:C27H38N6O5SPureza:98%Cor e Forma:SolidPeso molecular:558.69PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Fórmula:C20H24N6O2Pureza:99.89%Cor e Forma:SolidPeso molecular:380.44PI3K-IN-10
CAS:PI3K-IN-10 is a potent inhibitor of pan-PI3K .Fórmula:C23H19ClN6OPureza:98%Cor e Forma:SolidPeso molecular:430.89CAL-130
CAS:CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Fórmula:C23H22N8OPureza:98%Cor e Forma:SolidPeso molecular:426.47AZD3458
CAS:AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).Fórmula:C20H23N3O4S2Cor e Forma:SolidPeso molecular:433.54PI3K-IN-9
CAS:PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).Fórmula:C19H23N7OPureza:98%Cor e Forma:SolidPeso molecular:365.43CAL-130 Hydrochloride
CAS:CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Fórmula:C23H23ClN8OCor e Forma:SolidPeso molecular:462.94Vps34-IN-2
CAS:Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).Fórmula:C18H25F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:402.41PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Fórmula:C28H24N6O3Pureza:99.8%Cor e Forma:SolidPeso molecular:492.53PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Fórmula:C20H13ClF2N4O4SPureza:96.16%Cor e Forma:SolidPeso molecular:478.86Ref: TM-T12459
1mg55,00€5mg138,00€1mL*10mM (DMSO)144,00€10mg215,00€25mg358,00€50mg512,00€100mg692,00€200mg888,00€PI4KIII β inhibitor 3
CAS:PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).Fórmula:C22H22N8OSPureza:98%Cor e Forma:SolidPeso molecular:446.53PI3K-IN-6
CAS:PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).Fórmula:C17H14Cl2FN9OPureza:98%Cor e Forma:SolidPeso molecular:450.26CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Fórmula:C21H24ClN5O3S2Pureza:99.16%Cor e Forma:SolidPeso molecular:494.03Ref: TM-T10804
1mg96,00€5mg205,00€1mL*10mM (DMSO)224,00€10mg313,00€25mg562,00€50mg845,00€100mg1.153,00€PI3Kγ inhibitor 7
CAS:PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].Fórmula:C31H25N9O2Pureza:98%Cor e Forma:SolidPeso molecular:555.59
