PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 235 produtos para "PI3K".
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CAL-130 Racemate
CAS:CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Fórmula:C23H22N8OPureza:98%Cor e Forma:SolidPeso molecular:426.47PI3Kδ-IN-17
CAS:PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing theFórmula:C23H24F3N7O2Pureza:98%Cor e Forma:SolidPeso molecular:487.48SAR-260301
CAS:SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).Fórmula:C19H22N4O3Pureza:99.74%Cor e Forma:SolidPeso molecular:354.4Ref: TM-T16841
2mg43,00€5mg65,00€1mL*10mM (DMSO)71,00€10mg87,00€25mg173,00€50mg264,00€100mg371,00€200mg523,00€NVP-QAV-572
CAS:NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).Fórmula:C17H19F2N7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:471.5GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Fórmula:C18H22N6O2SPureza:99.77%Cor e Forma:White SolidPeso molecular:386.47Ref: TM-T22339
1mg52,00€5mg111,00€1mL*10mM (DMSO)120,00€10mg182,00€25mg289,00€50mg399,00€100mg530,00€MIPS-21335
CAS:MIPS-21335 is a potent PI3KC2α inhibitor with an IC50 value of 7 nM and additionally exhibits inhibitory activity against PI3KC2β, p110α, p110β, and p110δ withFórmula:C24H21N7O5Pureza:98%Cor e Forma:SolidPeso molecular:487.47PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).Fórmula:C24H26N6O3Pureza:99.98% - ≥98%Cor e Forma:SolidPeso molecular:446.5GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Fórmula:C27H18F5N5O4SPureza:97.03%Cor e Forma:SolidPeso molecular:603.52Ref: TM-T19840
1mg104,00€5mg215,00€1mL*10mM (DMSO)304,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€200mg1.251,00€PI3Kδ-IN-23
CAS:PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.Fórmula:C30H30N6O5Cor e Forma:SolidPeso molecular:554.596PI3Kα-IN-19
CAS:PI3Kα-IN-19 (Compound 1) serves as an inhibitor of PI3Kα, specifically targeting the p110α catalytic subunit. PI3Kα, a frequently dysregulated kinase, is extensively utilized in cancer research [1].Fórmula:C28H28N6O3Peso molecular:496.56UNI418
CAS:UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).Fórmula:C22H16N6Cor e Forma:SolidPeso molecular:364.40PI3Kδ-IN-27
CAS:PI3Kδ-IN-27 is a PI3Kδ inhibitor with an IC50 of 355.3 nM. It exhibits activity against SARS-CoV-2 and can be utilized in infection-related studies, such as those concerning COVID-19.Fórmula:C21H24N4O3Peso molecular:380.45PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Fórmula:C32H26N8O2SPureza:98%Cor e Forma:SolidPeso molecular:586.67PI3kδ inhibitor 1
CAS:PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).Fórmula:C28H33FN6O2Pureza:98%Cor e Forma:SolidPeso molecular:504.60VVD-699
CAS:VVD-699 is a covalent inhibitor of RAS-PI3K. It forms a covalent bond with cysteine at position 242 within the RAS-binding domain of PI3Kp110α, thereby obstructing the ability of RAS to activate PI3K. VVD-699 is capable of inhibiting the growth of tumors with RAS mutations and HER2 overexpression. It is applicable in research related to RAS mutation-associated cancers, such as those involving H358 lung cancer cells, A549 cells, and FaDu cells.Fórmula:C25H30ClFN2O6S2Cor e Forma:SolidPeso molecular:573.097
