PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 238 produtos para "PI3K".
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MSC2360844
CAS:MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).Fórmula:C26H27FN4O5SPureza:99.54% - 99.9%Cor e Forma:SolidPeso molecular:526.58Duvelisib (R enantiomer)
CAS:Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.Fórmula:C22H17ClN6OPureza:98%Cor e Forma:SolidPeso molecular:416.863PI3Kδ-IN-17
CAS:PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing theFórmula:C23H24F3N7O2Pureza:98%Cor e Forma:SolidPeso molecular:487.48PIK-inhibitors
CAS:PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.Fórmula:C19H17N5O2Pureza:96.98%Cor e Forma:SolidPeso molecular:347.37Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:White SolidPeso molecular:766.998PI3Kδ-IN-1
CAS:PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).Fórmula:C22H20F3N7O2Pureza:99.85%Cor e Forma:SolidPeso molecular:471.4351CAL-130 Racemate
CAS:CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Fórmula:C23H22N8OPureza:98%Cor e Forma:SolidPeso molecular:426.47PI3K-IN-51
CAS:PI3K-IN-51, characterized as a PI3K inhibitor, exhibits IC50 values below 500 nM for p120γ and p110δ/p85α (WO2016204429A1; Example 10) [1].Fórmula:C24H17Cl2N5O2Peso molecular:478.33NVP-QAV-572
CAS:NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).Fórmula:C17H19F2N7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:471.505740 Y-P
CAS:740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!Fórmula:C141H222N43O39PS3Pureza:98.3% - 99.87%Cor e Forma:White SolidPeso molecular:3270.7PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).Fórmula:C24H26N6O3Pureza:99.98% - ≥98%Cor e Forma:SolidPeso molecular:446.5016GSK-F1
CAS:GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.Fórmula:C27H18F5N5O4SPureza:97.03%Cor e Forma:SolidPeso molecular:603.52PI3Kδ-IN-23
CAS:PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.Fórmula:C30H30N6O5Cor e Forma:SolidPeso molecular:554.596PI3Kα-IN-19
CAS:PI3Kα-IN-19 (Compound 1) serves as an inhibitor of PI3Kα, specifically targeting the p110α catalytic subunit. PI3Kα, a frequently dysregulated kinase, is extensively utilized in cancer research [1].Fórmula:C28H28N6O3Peso molecular:496.56PI3Kδ-IN-27
CAS:PI3Kδ-IN-27 is a PI3Kδ inhibitor with an IC50 of 355.3 nM. It exhibits activity against SARS-CoV-2 and can be utilized in infection-related studies, such as those concerning COVID-19.Fórmula:C21H24N4O3Peso molecular:380.45PI3kδ inhibitor 1
CAS:PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).Fórmula:C28H33FN6O2Pureza:98%Cor e Forma:SolidPeso molecular:504.60UNI418
CAS:UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).Fórmula:C22H16N6Cor e Forma:SolidPeso molecular:364.40PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Fórmula:C32H26N8O2SPureza:98%Cor e Forma:SolidPeso molecular:586.67
