ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 71 produtos para "ATM/ATR".
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Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:99.13% - 99.92%Cor e Forma:Yellow SolidPeso molecular:414.45Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFórmula:C20H22ClN7OPureza:98.8% - 99.03%Cor e Forma:SolidPeso molecular:411.89Ref: TM-T10468
1mg34,00€5mg84,00€1mL*10mM (DMSO)92,00€10mg114,00€25mg224,00€50mg331,00€100mg470,00€200mg647,00€FEN1-IN-1
CAS:FEN1-IN-1 (LNT-1), a FEN1 active site inhibitor, partly works by coordinating Mg2+ ions.Fórmula:C15H12N2O5SPureza:99.72% - 99.93%Cor e Forma:White SolidPeso molecular:332.33Antitumor agent-28
CAS:Antitumor agent-28 inhibits ATM kinase, blocking ATM disease progression and showing anti-cancer effects.Fórmula:C25H32N6O4SCor e Forma:SolidPeso molecular:512.63GJ071 oxalate
CAS:GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.Fórmula:C20H29N3O7SPureza:99.93%Cor e Forma:White SolidPeso molecular:455.53Ref: TM-T31932
1mg73,00€5mg149,00€1mL*10mM (DMSO)166,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€Hexapeptide-11
CAS:Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.Fórmula:C36H48N6O7Pureza:98%Cor e Forma:SolidPeso molecular:676.8Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C24H25N5O3SPureza:97.34% - >99.99%Cor e Forma:SolidPeso molecular:463.55Ref: TM-T2669
1mg34,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg146,00€50mg213,00€100mg340,00€200mg497,00€500mg790,00€ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFórmula:C26H34N6O2Pureza:98%Cor e Forma:SolidPeso molecular:462.59ICT10336
ICT10336 is a hypoxia-reactive prodrug of the ATR inhibitor AZD6738. It specifically activates under hypoxic conditions in vitro, selectively releasing AZD6738. This action inhibits ATR activation at the T1989 and S428 phosphorylation sites, consequently disrupting HIF1a-mediated adaptation of hypoxic cancer cells and inducing cell death in both 2D and 3D cancer models. ICT10336 is also a metabolic substrate of CYPOR activity.Fórmula:C32H40N10O7SCor e Forma:SolidPeso molecular:708.28021CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Fórmula:C34H46N2O6SCor e Forma:SolidPeso molecular:610.80ATR-IN-9
CAS:ATR-IN-9 from patent WO2020087170A1 is a potent ATR kinase inhibitor with an IC50 of 10 nM.Fórmula:C22H27N7O2Cor e Forma:SolidPeso molecular:421.505Abd110
CAS:Abd110 (compound 42i), a Lenalidomide-based PROTAC ATR kinase degrader, selectively reduces levels of ATR and phospho-ATR while not impacting the related kinases ATM and DNA-PKcs [1].Fórmula:C41H42N8O7SCor e Forma:SolidPeso molecular:790.89ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Fórmula:C25H32N6O2Pureza:98%Cor e Forma:SolidPeso molecular:448.56GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Fórmula:C16H13N4NaO3SPureza:99.70% - 99.91%Cor e Forma:Orange SolidPeso molecular:364.36Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Fórmula:C20H24N6O2SPureza:98% - 99.99%Cor e Forma:White SolidPeso molecular:412.51AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Fórmula:C26H31N5O3Pureza:99.13% - 99.87%Cor e Forma:SolidPeso molecular:461.56CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Fórmula:C17H15N7O2Pureza:99.1% - 99.14%Cor e Forma:SolidPeso molecular:349.35KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Cor e Forma:Yellow SolidPeso molecular:395.49AZ20
CAS:AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Fórmula:C21H24N4O3SPureza:98% - 99.69%Cor e Forma:SolidPeso molecular:412.51NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Fórmula:C11H17N5O2Pureza:98.36%Cor e Forma:SolidPeso molecular:251.29PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.88Ref: TM-T2616
1mg42,00€5mg85,00€1mL*10mM (DMSO)94,00€10mg105,00€25mg200,00€50mg305,00€100mg427,00€200mg613,00€AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T7122
1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Fórmula:C23H18Cl3FN4O3SPureza:98% - 99.67%Cor e Forma:SolidPeso molecular:555.84Adefovir dipivoxil
CAS:Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFórmula:C20H32N5O8PPureza:98% - 99.80%Cor e Forma:SolidPeso molecular:501.47KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Fórmula:C30H33N3O5SPureza:95.9% - 99.7%Cor e Forma:Yellow SolidPeso molecular:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Fórmula:C18H16N4O3SPureza:97.19% - 99.97%Cor e Forma:SolidPeso molecular:368.41AZ32
CAS:AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.Fórmula:C20H16N4OPureza:98.68% - 99.68%Cor e Forma:SolidPeso molecular:328.37Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFórmula:C20H21N7OPureza:98.72% - 99.98%Cor e Forma:Yellow SolidPeso molecular:375.43Ref: TM-T7318
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg205,00€50mg340,00€100mg532,00€500mg1.144,00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Fórmula:C27H32FN5O2Pureza:97.41% - 99.72%Cor e Forma:White SolidPeso molecular:477.57Ref: TM-T5175
1mg84,00€2mg102,00€5mg152,00€1mL*10mM (DMSO)160,00€10mg215,00€25mg439,00€50mg560,00€100mg717,00€ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Fórmula:C30H22N4O2Pureza:97.76%Cor e Forma:SolidPeso molecular:470.52Mirin
CAS:Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.Fórmula:C10H8N2O2SPureza:99.24%Cor e Forma:SolidPeso molecular:220.25Ref: TM-T60273
2mg34,00€5mg46,00€1mL*10mM (DMSO)49,00€10mg67,00€25mg112,00€50mg168,00€100mg239,00€200mg353,00€ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Fórmula:C18H24N6O2SPureza:99.06% - >99.99%Cor e Forma:White SolidPeso molecular:388.49Ref: TM-T85731
1mg66,00€5mg145,00€1mL*10mM (DMSO)158,00€10mg200,00€25mg356,00€50mg505,00€100mg835,00€Ceralasertib formate
CAS:Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.Fórmula:C21H26N6O4SCor e Forma:SolidPeso molecular:458.54ATR-IN-15
CAS:ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.Fórmula:C19H22N8OCor e Forma:SolidPeso molecular:378.43SKLB-197
CAS:SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.Fórmula:C25H24N6OPureza:99.53%Cor e Forma:White SolidPeso molecular:424.5Ref: TM-T62290
1mg77,00€5mg167,00€1mL*10mM (DMSO)178,00€10mg260,00€25mg522,00€50mg835,00€100mg1.341,00€Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Fórmula:C25H29F2N9O3Pureza:99.52%Cor e Forma:SolidPeso molecular:541.55Ref: TM-T10407
1mg120,00€5mg289,00€1mL*10mM (DMSO)344,00€10mg485,00€25mg964,00€50mg1.414,00€100mg2.125,00€ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Fórmula:C27H24N4OCor e Forma:SolidPeso molecular:420.51ATR-IN-16
CAS:ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.Fórmula:C19H25N7OCor e Forma:SolidPeso molecular:367.45ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFórmula:C20H22N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:458.56ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Fórmula:C19H22N8OPureza:98%Cor e Forma:SolidPeso molecular:378.43ATM-IN-1
CAS:ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.Fórmula:C30H36N6O3Cor e Forma:SolidPeso molecular:528.65ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFórmula:C25H31N7OPureza:98%Cor e Forma:SolidPeso molecular:445.56(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Fórmula:C20H24N6O2SCor e Forma:SolidPeso molecular:412.51ATR-IN-6
CAS:ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.Fórmula:C28H28FN7O2Cor e Forma:SolidPeso molecular:513.57ATR-IN-18
CAS:ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.Fórmula:C19H22F3N7O5SCor e Forma:SolidPeso molecular:517.48ATR-IN-5
CAS:ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Fórmula:C27H32F3N9OCor e Forma:SolidPeso molecular:555.6ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Fórmula:C29H31N5O4SCor e Forma:SolidPeso molecular:545.65ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Fórmula:C23H27N7OPureza:98%Cor e Forma:SolidPeso molecular:417.51ATR-IN-13
CAS:ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Fórmula:C24H24FN9OCor e Forma:SolidPeso molecular:473.51
