ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 78 produtos para "ATM/ATR".
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AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Fórmula:C26H31N5O3Pureza:99.13% - 99.87%Cor e Forma:SolidPeso molecular:461.56CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Fórmula:C17H15N7O2Pureza:99.1% - 99.14%Cor e Forma:SolidPeso molecular:349.3467KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Cor e Forma:Yellow SolidPeso molecular:395.49NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Fórmula:C11H17N5O2Pureza:98.36%Cor e Forma:SolidPeso molecular:251.285PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Fórmula:C14H16ClN3O4S2Pureza:97.72%Cor e Forma:SolidPeso molecular:389.878AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.40CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Fórmula:C23H18Cl3FN4O3SPureza:98% - 99.67%Cor e Forma:SolidPeso molecular:555.84Adefovir dipivoxil
CAS:Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity againstFórmula:C20H32N5O8PPureza:98% - 99.80%Cor e Forma:SolidPeso molecular:501.47KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Fórmula:C30H33N3O5SPureza:95.9% - 99.7%Cor e Forma:Yellow SolidPeso molecular:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Fórmula:C18H16N4O3SPureza:97.19% - 99.97%Cor e Forma:SolidPeso molecular:368.41AZ32
CAS:AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.Fórmula:C20H16N4OPureza:98.68% - 99.68%Cor e Forma:SolidPeso molecular:328.3672Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFórmula:C20H21N7OPureza:98.72% - 99.98%Cor e Forma:Yellow SolidPeso molecular:375.43Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Fórmula:C27H32FN5O2Pureza:97.41% - 99.72%Cor e Forma:White SolidPeso molecular:477.5737ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Fórmula:C30H22N4O2Pureza:97.76%Cor e Forma:SolidPeso molecular:470.5213Mirin
CAS:Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.Fórmula:C10H8N2O2SPureza:99.24%Cor e Forma:SolidPeso molecular:220.248ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Fórmula:C18H24N6O2SPureza:99.06% - >99.99%Cor e Forma:White SolidPeso molecular:388.49ATR-IN-10
CAS:ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).Fórmula:C27H24N4OCor e Forma:SolidPeso molecular:420.51ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFórmula:C20H22N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:458.56Ceralasertib formate
CAS:Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.Fórmula:C21H26N6O4SCor e Forma:SolidPeso molecular:458.54
