ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 71 produtos de "ATM/ATR"
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CGK733
CAS:<p>CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.</p>Fórmula:C23H18Cl3FN4O3SPureza:98% - 99.67%Cor e Forma:SolidPeso molecular:555.84Adefovir dipivoxil
CAS:<p>Adefovir dipivoxil (GS 0840) is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against</p>Fórmula:C20H32N5O8PPureza:98% - 99.80%Cor e Forma:It Has Broad-Spectrum Antiviral ActivityPeso molecular:501.47KU60019
CAS:<p>Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.</p>Fórmula:C30H33N3O5SPureza:95.9% - 99.36%Cor e Forma:SolidPeso molecular:547.67VE-821
CAS:<p>VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).</p>Fórmula:C18H16N4O3SPureza:97.19% - 99.97%Cor e Forma:SolidPeso molecular:368.41AZ32
CAS:<p>AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.</p>Fórmula:C20H16N4OPureza:98.68% - 99.68%Cor e Forma:SolidPeso molecular:328.37Elimusertib
CAS:<p>Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in</p>Fórmula:C20H21N7OPureza:98.72% - 99.84%Cor e Forma:SolidPeso molecular:375.43Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54azd1390
CAS:<p>AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.</p>Fórmula:C27H32FN5O2Pureza:97.41% - 99.72%Cor e Forma:SolidPeso molecular:477.57ETP-46464
CAS:<p>ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).</p>Fórmula:C30H22N4O2Pureza:97.76%Cor e Forma:SolidPeso molecular:470.52Mirin
CAS:<p>Mirin is a Mre11-Rad50-Nbs1 (MRN) complex inhibitor and also inhibits Mre11-associated exonuclease activity.Mirin induces cell cycle arrest in G1 phase.</p>Fórmula:C10H8N2O2SPureza:99.24%Cor e Forma:SolidPeso molecular:220.25ART0380
CAS:<p>ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.</p>Fórmula:C18H24N6O2SPureza:99.06% - >99.99%Cor e Forma:SolidPeso molecular:388.49SKLB-197
CAS:<p>SKLB-197 targets ATR, inhibiting it at 0.013 μM, and is inactive on 402 other kinases, showing potent antitumor effects on ATM-deficient tumors.</p>Fórmula:C25H24N6OCor e Forma:SolidPeso molecular:424.5ATR-IN-10
CAS:<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Fórmula:C27H24N4OCor e Forma:SolidPeso molecular:420.51Ceralasertib formate
CAS:<p>Ceralasertib: an oral ATR kinase inhibitor that blocks CHK1 phosphorylation, disrupts DNA repair, and triggers tumor cell apoptosis.</p>Fórmula:C21H26N6O4SCor e Forma:SolidPeso molecular:458.54ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Fórmula:C19H22N8OCor e Forma:SolidPeso molecular:378.43Gartisertib
CAS:<p>Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.</p>Fórmula:C25H29F2N9O3Pureza:99.52%Cor e Forma:SolidPeso molecular:541.55ATR-IN-16
CAS:<p>ATR-IN-16 (compound 46) is an ATR kinase inhibitor with potent anticancer effects in LoVo cells, IC50 of 410 nM.</p>Fórmula:C19H25N7OCor e Forma:SolidPeso molecular:367.45ATR-IN-23
CAS:<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Fórmula:C20H22N6O3S2Pureza:98%Cor e Forma:SolidPeso molecular:458.56ATR-IN-6
CAS:<p>ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.</p>Fórmula:C28H28FN7O2Cor e Forma:SolidPeso molecular:513.57ATR-IN-18
CAS:<p>ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.</p>Fórmula:C19H22F3N7O5SCor e Forma:SolidPeso molecular:517.48
