ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 71 produtos para "ATM/ATR".
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ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Fórmula:C19H22N8OPureza:98%Cor e Forma:SolidPeso molecular:378.43ATM-IN-1
CAS:ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.Fórmula:C30H36N6O3Cor e Forma:SolidPeso molecular:528.65ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFórmula:C25H31N7OPureza:98%Cor e Forma:SolidPeso molecular:445.56(S)-Ceralasertib
CAS:(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.Fórmula:C20H24N6O2SCor e Forma:SolidPeso molecular:412.51ATR-IN-6
CAS:ATR-IN-6: potent ATR kinase inhibitor for cancer treatment, referenced in patent WO2021233376A1 as compound A22.Fórmula:C28H28FN7O2Cor e Forma:SolidPeso molecular:513.57ATR-IN-18
CAS:ATR-IN-18: oral ATR inhibitor, IC50 0.69 nM; halts LoVo cell growth, IC50 37.34 nM; anti-tumor.Fórmula:C19H22F3N7O5SCor e Forma:SolidPeso molecular:517.48ATR-IN-5
CAS:ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.Fórmula:C27H32F3N9OCor e Forma:SolidPeso molecular:555.6ATR-IN-20
ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.Fórmula:C29H31N5O4SCor e Forma:SolidPeso molecular:545.65ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Fórmula:C23H27N7OPureza:98%Cor e Forma:SolidPeso molecular:417.51ATR-IN-13
CAS:ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).Fórmula:C24H24FN9OCor e Forma:SolidPeso molecular:473.51AZ 5704
CAS:AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan.Fórmula:C23H23FN6O2Pureza:99.69%Cor e Forma:White SolidPeso molecular:434.47ATR-IN-8
CAS:ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.Fórmula:C20H22N6O2SCor e Forma:SolidPeso molecular:410.49AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Fórmula:C24H28N4O3Pureza:98.1%Cor e Forma:SolidPeso molecular:420.5Camonsertib
CAS:Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Fórmula:C21H26N6O3Pureza:98.44% - 99.93%Cor e Forma:Yellow SolidPeso molecular:410.47Ref: TM-T62083
1mg160,00€1mL*10mM (DMSO)356,00€5mg394,00€10mg573,00€25mg893,00€50mg1.189,00€100mg1.639,00€200mg2.205,00€Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFórmula:C23H21FN6O3Pureza:99.9%Cor e Forma:White SolidPeso molecular:448.45Ref: TM-T62684
10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg123,00€2mg177,00€5mg295,00€1mL*10mM (DMSO)326,00€ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Fórmula:C26H29FN6O3Cor e Forma:SolidPeso molecular:492.55ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Fórmula:C25H29FN6O3Cor e Forma:SolidPeso molecular:480.53ATR-IN-11
ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.Fórmula:C25H30N6O2Cor e Forma:SolidPeso molecular:446.54WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Fórmula:C23H23F2N5O2Cor e Forma:SolidPeso molecular:439.46Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Fórmula:C14H17N3O4Cor e Forma:SolidPeso molecular:291.302
