ATM/ATR
Os inibidores de ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) têm como alvo quinases chave envolvidas na resposta ao dano ao DNA (DDR) que são ativadas em resposta a quebras de fita dupla de DNA e estresse de replicação. Esses inibidores perturbam a capacidade dessas quinases de detectar e reparar danos no DNA, o que pode levar a um aumento da instabilidade genômica e morte celular, particularmente em células cancerígenas que dependem de mecanismos robustos de reparo do DNA para sobreviver. Os inibidores de ATM/ATR são ferramentas cruciais na pesquisa e terapia do câncer, especialmente em combinação com agentes que causam danos ao DNA. Na CymitQuimica, oferecemos uma ampla gama de inibidores de ATM/ATR de alta qualidade para apoiar sua pesquisa em resposta ao dano ao DNA, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 71 produtos de "ATM/ATR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
ATR-IN-29
CAS:<p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>Fórmula:C19H22N8OPureza:98%Cor e Forma:SolidPeso molecular:378.43ATR-IN-13
CAS:<p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>Fórmula:C24H24FN9OCor e Forma:SolidPeso molecular:473.51AZ 5704
CAS:<p>ATM kinase inhibitor with 0.6 nM IC50, >600-fold selective, enhances irinotecan effects, oral use.</p>Fórmula:C23H23FN6O2Cor e Forma:SolidPeso molecular:434.47ATR-IN-8
CAS:<p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>Fórmula:C20H22N6O2SCor e Forma:SolidPeso molecular:410.49ATR-IN-22
CAS:<p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>Fórmula:C25H31N7OPureza:98%Cor e Forma:SolidPeso molecular:445.56ATR-IN-20
<p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>Fórmula:C29H31N5O4SCor e Forma:SolidPeso molecular:545.65ATR-IN-5
CAS:<p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>Fórmula:C27H32F3N9OCor e Forma:SolidPeso molecular:555.6(S)-Ceralasertib
CAS:<p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>Fórmula:C20H24N6O2SCor e Forma:SolidPeso molecular:412.51ATR-IN-21
CAS:<p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>Fórmula:C23H27N7OPureza:98%Cor e Forma:SolidPeso molecular:417.51ATM-IN-1
CAS:<p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>Fórmula:C30H36N6O3Cor e Forma:SolidPeso molecular:528.65Camonsertib
CAS:<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Fórmula:C21H26N6O3Pureza:99.6% - 99.93%Cor e Forma:SolidPeso molecular:410.47AZ31
CAS:<p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,</p>Fórmula:C24H28N4O3Pureza:98.01%Cor e Forma:SolidPeso molecular:420.5Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Fórmula:C23H21FN6O3Pureza:99.9%Cor e Forma:SolidPeso molecular:448.45ATR-IN-17
CAS:<p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>Fórmula:C22H28N6O2SCor e Forma:SolidPeso molecular:440.56ATM Inhibitor-4
<p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>Fórmula:C26H29FN6O3Cor e Forma:SolidPeso molecular:492.55ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Cor e Forma:SolidPeso molecular:489.57ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Cor e Forma:SolidPeso molecular:480.53Decarbamoylmitomycin C
CAS:<p>Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.</p>Fórmula:C14H17N3O4Cor e Forma:SolidPeso molecular:291.302WSD0628
CAS:<p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>Fórmula:C23H23F2N5O2Cor e Forma:SolidPeso molecular:439.46ATM Inhibitor-1
CAS:<p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>Fórmula:C27H36N6O3Pureza:98%Cor e Forma:SolidPeso molecular:492.61
