mTOR
Os inibidores de mTOR são compostos que inibem a atividade do Alvo da Rapamicina em Mamíferos (mTOR), um regulador central do crescimento celular, proliferação, metabolismo e sobrevivência. A via de sinalização mTOR é frequentemente alterada em casos de câncer e outras doenças, tornando o mTOR um alvo crítico para intervenções terapêuticas. Inibidores de mTOR são amplamente utilizados em pesquisas relacionadas ao câncer, envelhecimento e distúrbios metabólicos. Na CymitQuimica, oferecemos uma variedade de inibidores de mTOR para apoiar sua pesquisa em transdução de sinais, oncologia e desenvolvimento terapêutico.
Foram encontrados 144 produtos de "mTOR"
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Zotarolimus
CAS:<p>Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).</p>Fórmula:C52H79N5O12Pureza:95% - 98.01%Cor e Forma:SolidPeso molecular:966.21(+)-Usnic acid
CAS:<p>(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.</p>Fórmula:C18H16O7Pureza:98.22%Cor e Forma:SolidPeso molecular:344.32CZ415
CAS:<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Cor e Forma:SolidPeso molecular:459.56VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Fórmula:C17H22N8OPureza:97.82% - 99.54%Cor e Forma:SolidPeso molecular:354.41Dihydromyricetin
CAS:<p>Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.</p>Fórmula:C15H12O8Pureza:96.68% - 98.229%Cor e Forma:SolidPeso molecular:320.25MHY1485
CAS:<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Fórmula:C17H21N7O4Pureza:97.74% - >99.99%Cor e Forma:SolidPeso molecular:387.39ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Fórmula:C16H17N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54PQR620
CAS:<p>PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.</p>Fórmula:C21H25F2N7O2Pureza:97.61%Cor e Forma:SolidPeso molecular:445.47DMH-25
CAS:<p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>Fórmula:C15H8Br3NO3Pureza:99.26%Cor e Forma:SolidPeso molecular:489.94Ridaforolimus
CAS:<p>Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。</p>Fórmula:C53H84NO14PPureza:90.00% - 98.55%Cor e Forma:Off-White SolidPeso molecular:990.21DIM-C-pPhOH
CAS:<p>CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.</p>Fórmula:C23H18N2OPureza:98.61%Cor e Forma:SolidPeso molecular:338.4CC-115
CAS:<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Fórmula:C16H16N8OPureza:86.79% - 99.01%Cor e Forma:SolidPeso molecular:336.35PQR530
CAS:<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Fórmula:C18H23F2N7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:407.42PKCβ inhibitor 1
CAS:<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Fórmula:C24H21N5O2Pureza:99.33%Cor e Forma:SolidPeso molecular:411.46KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Fórmula:C33H34N4O4SPureza:98.75%Cor e Forma:SolidPeso molecular:582.71Desmethyl-VS-5584
CAS:<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Fórmula:C16H20N8OPureza:>99.99%Cor e Forma:SolidPeso molecular:340.38MHY-1685
CAS:<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Fórmula:C11H8N2O4Pureza:99.76%Cor e Forma:SolidPeso molecular:232.19DS-7423
CAS:<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Fórmula:C22H27F3N10O2Pureza:99.98%Cor e Forma:SolidPeso molecular:520.51Gedatolisib
CAS:<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Fórmula:C32H41N9O4Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:615.73
