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1-Methylindole-2-Carboxylic Acid is a chemical that belongs to the group of phenylacetic acid compounds. It has been shown to inhibit lymphocyte activation and t-cell proliferation in vitro, which may be due to its ability to interfere with the production of interleukin. 1-Methylindole-2-Carboxylic Acid also has an antitumor effect on animals and can reduce the tumor burden by inhibiting DNA synthesis, protein synthesis, and mineralization. The molecular modeling studies have shown that 1-Methylindole-2-Carboxylic Acid binds in the active site of protein kinase C as a competitive inhibitor and prevents ATP from binding to the enzyme.

8-Azahypoxanthine is a hydroxyl analog of hypoxanthine. It contains a nitrogen atom in place of the oxygen atom on the 2-position. 8-Azahypoxanthine has been shown to be an effective inhibitor of purine biosynthesis in yeast cells and can be used as a replacement for xanthine during the synthesis of adenosine triphosphate (ATP) from uracil. 8-Azahypoxanthine was found to have good detection sensitivity, with an estimated detection limit of 0.2 µM. The optimum pH for this compound is 7.8, which is similar to that of wild type strain and tissue culture media. Mutants resistant to 8-azahypoxanthine were generated by exposure to high concentrations (>100 mM) for long periods (>2 days). Mutant strains showed no detectable enzyme activity against orotic acid or glycosidic bond formation with erythromycin

2,2,4-Trimethyl-1,2-dihydroquinolin-6-ol (TQ) is a naturally occurring phenolic compound that has been shown to inhibit lipid peroxidation in animal and human cells. TQ is an antioxidant that protects against oxidative damage by scavenging free radicals. This compound can act as a nitroxyl radical trap and inhibits the dimerization of quinones and other reactive oxygen species. TQ also has been found to have anti-inflammatory effects, which may be due to its ability to reduce the production of inflammatory cytokines.
A new study shows that TQ can inhibit the production of reactive oxygen species in quantum yields up to 10%. It is thought that this effect may be due to TQ’s ability to stabilize different forms of reduced glutathione.

3-(2-Diisopropylaminoethyl)indole hydrochloride is an inhibitor of the enzyme monoamine oxidase (MAO). MAO is responsible for the degradation of monoamines such as serotonin, dopamine, and norepinephrine. 3-(2-Diisopropylaminoethyl)indole hydrochloride inhibits these enzymes in order to increase the levels of these neurotransmitters in the brain. These effects are observed with a sectional study on the host plant species. 3-(2-Diisopropylaminoethyl)indole hydrochloride has been shown to have low potency for inhibiting 5-HT1A and 5-HT2A receptors in rat studies, but it is not active against 5-HT2C receptors. This drug was used to measure urinary serotonin and dopamine levels in human urine samples.

3-Aminoquinoline is a chemical compound that inhibits the activity of the epidermal growth factor receptor (EGFR). It is a potent inhibitor of cell proliferation and has been shown to have antitumour activity. 3-Aminoquinoline has been shown to inhibit the proliferation of carcinoma cell lines. This drug binds to the EGFR receptor, preventing it from activating downstream signalling pathways that control cell growth. 3-Aminoquinoline also has biological properties, including matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, analytical chemistry, sample preparation, and Suzuki coupling reaction. The molecule is structurally analyzed using chemical structures and structural analysis techniques such as thermodynamic data or proton NMR spectroscopy. 3-Aminoquinoline also interacts with sugars through hydrogen bonding and oligosaccharides. These interactions are found to be high in value in some cases.

6-Ethylmercaptopurine is a purine analogue that inhibits the synthesis of DNA. It is used as an inhibitor of protein synthesis and in the treatment of inflammatory bowel disease. 6-Ethylmercaptopurine has been shown to inhibit the activity of ATPase, which may be responsible for its ability to suppress the proliferation of cells. This drug can also act as an analog to adenosine, which can be used to determine ATP levels in a cell or tissue sample by measuring the amount of p-nitrophenyl phosphate produced. 6-Ethylmercaptopurine has been shown to block phosphatase activity, which may lead to inflammation in some cases.
6-Ethylmercaptopurine has a molecular weight of 194.2 g/mol and an optimum pH of 4.5

(1,10)Phenanthrolin-5-ylamine is a sample preparation reagent that has been used in the production of polymers with redox potentials below 0.2 V. This compound is also an antimicrobial agent that has shown to be effective against bacteria and fungi. The detection sensitivity of (1,10)phenanthrolin-5-ylamine is high, making it suitable for use in human serum samples. It can be protonated by a base such as sodium hydroxide or ammonia to form its cationic form, which can then react with nucleophiles such as thiols and amines to produce an alkylating agent. It has been used in the synthesis of l1210 murine leukemia cells and has been observed to have photophysical properties that are sensitive to neutral pH levels.
(1,10)Phenanthrolin-5-ylamine can be used for process optimization

5,7-Dimethoxyindole is a potent inhibitor of the enzyme oxidase. 5,7-Dimethoxyindole has been shown to inhibit the growth of a number of fungi, including Phytophthora infestans and Cryptococcus neoformans. The molecular modeling studies have shown that this molecule can form an H-bond with the acceptor in the active site of the enzyme and prevent access by substrate. This inhibition has been shown to be competitive with respect to ferrous ions and noncompetitive with respect to other cofactors. 5,7-Dimethoxyindole also inhibits integrase enzymes, which are involved in DNA integration during viral replication. 5,7-Dimethoxyindole was found to bind to a pharmacophore model for integrase inhibitors and formylation reactions. This compound is also magnetic due to its high electron density at the methoxy group.

3-Aminoquinuclidine dihydrochloride (3-AQDH) is a chiral quinuclidine derivative that is an acetylcholine receptor agonist. It has been shown to bind to the α7 nicotinic acetylcholine receptor with high affinity and selectivity. 3-AQDH has also been shown to crosslink the cholinergic receptor, which may lead to increased sensitivity of the receptor. The binding constants between 3-AQDH and the α7 nicotinic acetylcholine receptors are very high and it has been shown to be enantiopure in its synthesis. 3-AQDH also has a hydrophilic interaction chromatography profile, which separates it from other compounds. This agent may have potential use as a drug for treating Alzheimer's disease and Parkinson's disease due to its ability to inhibit acetylcholinesterase activity.

3-Quinolinecarboxylic acid is a water-soluble drug that is soluble in both organic solvents and water. It is reactive, which limits its therapeutic use. 3-Quinolinecarboxylic acid is used to treat inflammatory disease by inhibiting the production of prostaglandins and leukotrienes in the body. 3-Quinolinecarboxylic acid has been shown to have genotoxic effects on primary cells, as well as an antiinflammatory effect. It also has been shown to be effective for treating rheumatoid arthritis in animal models, but not humans.

4-Chloro-5-ethylisatin is a fine chemical that can be used as a versatile building block in the synthesis of complex compounds. It has been shown to be a useful intermediate and reaction component for the preparation of high quality reagents. 4-Chloro-5-ethylisatin is commercially available from Sigma Aldrich, catalog number 1379340-45-0.

4,7-Dichloroisatin is an organic compound that is synthesized by ring-opening of oxindole. It is a bifunctional molecule that can be used for the synthesis of other organic compounds. 4,7-Dichloroisatin has been found to be an efficient method for the synthesis of thiazolidinedione derivatives and can be used as a control experiment for this type of reaction. The mechanism for the reaction includes nitroaldol addition to the C=O group, followed by nucleophilic attack on the carbonyl group to form a tetrahedral intermediate. The intermediate then collapses to form a new C=N bond and release acetonitrile.

Oxythiamine chloride is a compound that binds to DNA in the nucleus of cells. It has been shown to inhibit cell growth and induce apoptosis by binding to a number of cellular molecules, including hydrogen bonding interactions with enzymes. Oxythiamine chloride also inhibits energy metabolism by inhibiting mitochondrial respiration and mitochondrial ATP production, and is toxic to cells. This drug has potent inducers, such as cell factor, which are necessary for the production of new cells. It also inhibits thiamine-dependent enzymes, such as pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase (PDH). The wild-type strain of Escherichia coli was used for these studies.

2-(2-Aminophenyl)benzimidazole is a synthetic compound with the chemical formula C8H6N2. It has an intramolecular hydrogen bond and reacts with salicylaldehyde to form 2-aminobenzimidazole, which is a reaction product. 2-(2-Aminophenyl)benzimidazole may be used as an antimicrobial agent, but it also has other uses such as a reagent in organic synthesis. It is soluble in water and can be obtained through liquid chromatography.

Please enquire for more information about 3-(4-Bromophenyl)-5-(hydroxyimino)-7,7-dimethyl-6,7,8-trihydrocinnoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Oxoindoline-3-hydrazone (2OIH) is a heterocyclic compound that has been reported to have anticancer activity. 2OIH is an intramolecular hydrogen bond acceptor, which may account for its anticancer activity. It has been shown to be effective against cancer cells in mammalian cell lines and in vitro studies of human carcinoma cell lines. This compound also showed anticancer activity against bacteria such as Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus). The geometric isomers of 2OIH have been studied using nmr spectra, and the carbonyl group has been identified as the source of its anti-cancer properties. Structural analysis has revealed that the hydroxyl group on the indole moiety is important for the anti-cancer properties of this molecule.

Please enquire for more information about 1-(2-Chloropropanoyl)indoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 3,5-Dichloro-4-pyridone-1-acetic acid

Applications 1,8,8-trimethyl-3-azabicyclo[3.2.1]octane hydrochloride is a useful research chemical, a camphidine derivative with multiple synthetic applications.
References Rubinstein, K., et al.: Acta Chem. Scand., 17, 2061 (1963); Manzoor-I-Khuda, M., et al.: Pak. J. Sci. Ind. Res., 10, 97 (1967)

Stability Hygroscopic
Applications 2-(1,3-Dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic Acid (cas# 52208-61-4) is a useful research chemical.

Applications 8-aza-9-boratricyclo[8.4.0.0,2,7]tetradeca-1(14),2,4,6,10,12-hexaen-9-ol (cas# 17012-25-8) is a useful research chemical.

Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.
References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);

Applications 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (cas# 885273-81-4) is a useful research chemical.

Applications 4-(ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 18630-93-8) is a useful research chemical.

Applications 4-Chloro-7-(trifluoromethyl)quinoline is a reagent in the preparation of piperazinylquinolines as breast cancer inhibitors.
References Solomon, V., et al.: Bioorg. Med. Chem., 18, 1563 (2010);

Applications 2-Amino-6,8-dihydroxypurine is an 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase λ.
References Avkin, S., et al.: Mutat. Res., 510, 81 (2002), Niimi, N., et al.: Biochem., 48, 4239 (2009), Muftuoglu, M., et al.: J. Biol. Chem., 284, 9270 (2009),