Outros inibidores

5-Phenyl-1H-pyrrole-3-carbaldehyde is a useful organic compound for research related to life sciences. The catalog number is T66775 and the CAS number is 56448-22-7.

<p>Benzyl-PEG4-THP is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid is a useful organic compound for research related to life sciences. The catalog number is T67178 and the CAS number is 1012341-48-8.

3,4-Dibutoxycyclobut-3-ene-1,2-dione is a useful organic compound for research related to life sciences. The catalog number is T66750 and the CAS number is 2892-62-8.

Type III-Intermediate 8 is a useful organic compound for research related to life sciences and the catalog number is T9562.

<p>SHP2 degrader-1: highly efficient, induces SHP2 degradation &amp; cell apoptosis, shows promise in SHP2-related disease research.</p>

5-Methyl-3,4-diphenylisoxazole is a useful organic compound for research related to life sciences. The catalog number is T66198 and the CAS number is 37928-17-9.

<p>Apoptosis Inducer 4 (Compound 12b) is a compound that induces apoptosis and exhibits anticancer properties [1].</p>

3,4-Difluorobenzaldehyde is a useful organic compound for research related to life sciences. The catalog number is T65937 and the CAS number is 34036-07-2.

Sodium pyrophosphate (Disodium pyrophosphate), an inorganic food additive, exhibits potential hematotoxic and immunotoxic effects [1].

2-(3-(4-Methylbenzoyl)phenyl)propanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64773.

<p>PRO-6E is an orally active, Cereblon ligand-based PROTAC that promotes MET degradation, achieving up to 81.9% effectiveness at a concentration of 1 μM in MKN-45 cells. It demonstrates tumor growth inhibition both in vivo and in vitro, alongside inducing cell apoptosis and cell cycle arrest.</p>

3-Chloro-N,N-dimethylpropan-1-amine is a useful organic compound for research related to life sciences and the catalog number is T65676.

(S)-2-((S)-2-Amino-3-methylbutanamido)-4-(methylthio)butanoic acid (catalog number: T66954) is a valuable organic compound used in life sciences research.

exo-2-Aminonorbornane is a useful organic compound for research related to life sciences. The catalog number is T65169 and the CAS number is 7242-92-4.

6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T64405 and the CAS number is 1006-21-9.

λ-Carrageenan, a seaweed-derived polysaccharide, is commonly utilized as a proinflammatory agent in basic research and has also been identified as a potent antitumor agent [1].

<p>Tetraphenylporphine sulfonate (TPPS) serves as a non-cytotoxic probe suitable for tumor localization detection [1].</p>

<p>5-Chloro-2-(methylamino)benzophenone is a useful organic compound for research related to life sciences. The catalog number is T65450 and the CAS number is 1022-13-5.</p>

(R)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65537 and the CAS number is 218608-98-1.

(-)-Corey lactone benzoate, catalog number T66946 and CAS number 39746-00-4, is a valuable organic compound for life sciences research.

Methyl 4,5-dichlorothiophene-2-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66373 and the CAS number is 89281-29-8.

Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65566 and the CAS number is 161798-03-4.

<p>3-Bromo-2-methylaniline, catalog number T65643 [CAS number 55289-36-6], is a valuable organic compound for life sciences research.</p>

<p>MCA17-1 exhibits superior bioactivity compared to the positive control, obeticholic acid (OCA), in the treatment of liver fibrosis.</p>

<p>Podoblastin A (D-mannitol) is a useful organic compound for research related to life sciences and the catalog number is TSP-41077145.</p>

<p>Polystyrene microplastics (PS-MPs) are a toxic substance that poses risks to aquatic life, specifically causing cardiac harm to zebrafish and inducing male reproductive toxicity in mice [1] [2].</p>

Chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T64659.

1-(2-Chlorophenyl)piperazine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65963 and the CAS number is 41202-32-8.

1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone is a useful organic compound for research related to life sciences. The catalog number is T67589 and the CAS number is 67914-60-7.

4-Perhydroazepinone hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66790 and the CAS number is 50492-22-3.

<p>TLR7/8 agonist-7d is a useful organic compound for research related to life sciences and the catalog number is T64606.</p>

<p>22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]</p>

3-Amino-1H-pyrazole-4-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66363 and the CAS number is 16617-46-2.

Morpholino C subunit is a useful organic compound for research related to life sciences and the catalog number is T64772.

Benzyl 2-(2-benzyl-3-mercaptopropanamido)acetate is a useful organic compound for research related to life sciences and the catalog number is T66864.

(S)-7,7'-Bis(bis(3,5-dimethylphenyl)phosphaneyl)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene] is a useful organic compound for research related to life sciences and the catalog number is T65595.

Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS) utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

Cpd.7 of 1326852-06-5 is a useful organic compound for research related to life sciences. The catalog number is T9559 and the CAS number is 2411843-75-7.

2,6-Bis[[(R)-2-[hydroxy(diphenyl)methyl]-1-pyrrolidinyl]methyl]-4-methylphenol is a useful organic compound for research related to life sciences and the catalog number is T66791.

Cyclofos-4 is a useful organic compound for research related to life sciences. The catalog number is TF0104 and the CAS number is 675126-15-5.

2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethanol dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T64940 and the CAS number is 164726-80-1.

<p>5-Methyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T65362 and the CAS number is 138564-59-7.</p>

(4-Methoxy-3,5-dimethylpyridin-2-yl)methyl acetate is a useful organic compound for research related to life sciences. The catalog number is T67186 and the CAS number is 91219-90-8.

SulfoxFluor has a wide range of applications in life science related research.

Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)silane is a useful organic compound for research related to life sciences. The catalog number is T67125 and the CAS number is 101947-16-4.

PF-06445974 has good selectivity for PDE4D, excellent brain permeability, and has a high level of specific binding in the "cold tracer" study.

<p>2', 3'-cGAMP-C2-SH is a ADC cytotoxin.</p>

(R)-Boc-3-(trifluoromethyl)-β-Phe-OH, catalog number T66698 and CAS number 501015-18-5, is a valuable organic compound for life sciences research.

<p>Bikunin/AMBP Protein, Human, Recombinant (aa 1-203, His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Hantaan virus HTNV (strain 84FLi) Nucleocapsid/NP Protein (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Lipocalin-2/LCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>CF502 (STING agonist-23) is a non-nucleotide that activates STING pathway, boosts immune responses, and shows activity against SARS-CoV.</p>

<p>Valiloxibic acid is a prodrug for GHB, a natural psychoactive neurotransmitter and weak GABAB agonist.</p>

<p>S100A8 &amp; S100A9 Heterodimer Protein, Human, Recombinant (Flag &amp; His) is expressed in Baculovirus insect cells with Flag and His tag.</p>

<p>HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.</p>

<p>HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes.</p>

Intermediates and building blocks - phosphorous compounds; nucleophile

<p>Heterocyclic compounds-pyridine,</p>

<p>Alpha-Synuclein Protein, Human, Recombinant is expressed in E.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta).</p>

<p>Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and</p>

<p>LPL Protein, Chinese hamster, Recombinant (His) is expressed in E.</p>

<p>BCL-W Protein, Human, Recombinant (His) is expressed in E.</p>

<p>NBQX (FG9202), an AMPA/kainate receptor blocker, counters glutamate toxicity; water-soluble as disodium salt, has anticonvulsant properties.</p>

<p>10Z-Nonadecenoic acid is a long-chain fatty acid with anti-tumor activity.</p>

<p>Tropinone used as an intermediate in the synthesis of atropine sulfate, and is a decane alkaloid.</p>

<p>Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C</p>

<p>Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.</p>

<p>7-Methoxy-1-tetralone may have insecticidal activity.</p>

<p>Elamipretide 2TFA (RX-31 2TFA) is a novel mitochondrion-targeted antioxidant.</p>

<p>MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.</p>

<p>Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.</p>

Decyl-TPP bromide ((1-Decyl)triphenylphosphonium bromide) may be used as an intermediate for chemical synthesis and an inactive control or as a reference to

<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>

<p>4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation.</p>

<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>

<p>Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-focused peptide that curbs toxic ROS and stabilizes cardiolipin.</p>

<p>Dimethylamine hydrochloride, found in urine, comes from food compound TMAO and NO synthesis inhibitor ADMA, processed by DDAH enzyme.</p>

<p>FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. IGFBP-1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.9 kDa and the accession number is P21743.</p>

<p>May act as a negative regulator of collagen matrix deposition.</p>

<p>SLC1A2 Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is P43006.</p>

<p>Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].</p>

(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride, a potent antagonist of proNGF (nerve growth factor).

<p>Albuterol stearate, a salt form of Albuterol, is a selective beta2 agonist for treating asthma and COPD, with 29x preference for beta2 over beta1.</p>

TRPP3 channel inhibitor

D(-)-Octopamine CSA salt is an agonist of octopamine receptors.

<p>KP372-1, an Akt inhibitor, blocks PI3K signaling, arrests cell growth, and triggers apoptosis in head/neck squamous cell carcinoma.</p>

FM-24 HCl is a long acting beta-adrenergic receptor antagonist.

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.

Guancydine is an antihypertensive agent.

MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).

<p>HPK1-IN-18: Potent, specific inhibitor of HPK1, a MAP4K enzyme, for cancer research and treatment.</p>

IDX-375, a HCV NS5B polymerase inhibitor, is used potentially for the treatment of HCV infection.

<p>Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties.</p>

H 35-25 is a beta 2-antagonist.

<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>

<p>(E)-Crotylbarbital, a Crotylbarbital isomer, is a sedative with hypnotic, anticonvulsant properties, aiding sleep and mental stability.</p>

CK176 is an HIV-1 inhibitor, 11x more effective than I-XW-053 in human PBMCs.

<p>AKOS-22: potent VDAC1 inhibitor, Kd=15.4 μM; prevents mitochondrial dysfunction and apoptosis.</p>

Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity.

<p>Questiomycin A derivative 18 TFA exhibits antibacterial, anticancer properties and inhibits GRP78.</p>

Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties.

CH-100 is a Chinese herbal medicine previously used in the treatment of human hepatitis C.

<p>Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.</p>

Fosfonet sodium is a sodium salt of phosphonoacetic acid, effective against herpesviruses by inhibiting viral DNA polymerase.

<p>PL265 is a long-acting dual ENKephalinase inhibitor (DENKi) with analgesic potential.</p>

<p>Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.</p>

<p>Culmerciclib is a cell cycle protein-dependent kinase (CDK) inhibitor that exhibits antitumour effects.</p>

PSB-6426 is the first potent and selective human nucleoside triphosphate diphosphohydrolase-2 inhibitor.

Aminobutane bisphosphonate curbs bone loss; may manage hypercalcemia in cancer.

<p>BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (</p>

<p>Erythrityl Tetranitrate, a vasodilator similar to nitroglycerin, was first in "sustained release" tablets; may cause "nitro headache."</p>

DPX-3778, a triethanolamine salt, boosts tobacco callus growth 4-5x at 0.124-2.48 μM and slows aging with IAA and kinetin.

<p>Radafaxine hydrochloride is an inhibitor of DAT and NET transporters, and nAChR family modulator.</p>

<p>PS372424 activates CXCR3, triggers ERK phosphorylation, and inhibits CXCL11's effect on CD45+ cell migration in humanized mice.</p>

<p>Phenazolam is an analytical reference standard categorized as a benzodiazepine. [1] This product is intended for research and forensic applications.</p>

<p>Benzovindiflupyr: a fungicide that inhibits SDH (IC50=5.2nM), halts S. sclerotiorum growth (EC50=0.011μg/ml), and protects crops like eggplants.</p>

<p>PAD4-IN-2 (compound 5i) is a PAD4 inhibitor with an IC50 value of 1.94 μM, shown to suppress tumor growth in mice through specific inhibition of the PAD4-H3cit-</p>