Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1382 produtos de "Sinalização Citoesquelética"
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KY-02327 acetate
<p>KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.</p>Fórmula:C22H31N3O6Cor e Forma:SolidPeso molecular:433.5RMS-07
CAS:<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Fórmula:C35H40N8O2Cor e Forma:SolidPeso molecular:604.74SR121566A
CAS:<p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>Fórmula:C20H25N5O4SPureza:98%Cor e Forma:SolidPeso molecular:431.51C086
CAS:<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Fórmula:C29H28O8Cor e Forma:SolidPeso molecular:504.536-B345TTQ
CAS:<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Fórmula:C22H20BrNO4Cor e Forma:SolidPeso molecular:442.303MT-134
<p>MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.</p>Fórmula:C19H16N4O3Cor e Forma:SolidPeso molecular:348.36Tau ligand-1
CAS:<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>Fórmula:C17H16FN3OCor e Forma:SolidPeso molecular:297.327Nrf2/HO-1 activator 2
<p>Compound 13m, a difluoro derivative, activates Nrf2/HO-1, showing neuroprotective and antioxidant effects, useful in PD research.</p>Fórmula:C20H16F2O5Cor e Forma:SolidPeso molecular:374.33GR 83895
CAS:<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Fórmula:C29H39N9O8SPureza:98%Cor e Forma:SolidPeso molecular:673.74Des-ethyl-carafiban
CAS:<p>Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.</p>Fórmula:C22H23N5O5Cor e Forma:SolidPeso molecular:437.448POSH-IN-2
CAS:<p>POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.</p>Fórmula:C22H16N2O2Cor e Forma:SolidPeso molecular:340.37GSK3335103
CAS:<p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>Fórmula:C27H36FN3O4Cor e Forma:SolidPeso molecular:485.59FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Fórmula:C18H20N4O4SCor e Forma:SolidPeso molecular:388.44NRX-2663
CAS:<p>NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).</p>Fórmula:C20H13F3N2O5Cor e Forma:SolidPeso molecular:418.32Fradafiban
CAS:<p>Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.</p>Fórmula:C20H21N3O4Pureza:98%Cor e Forma:SolidPeso molecular:367.40Hsp110-STAT3 interaction-IN-1
CAS:<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Fórmula:C23H31N3O4SCor e Forma:SolidPeso molecular:445.58Tubulin polymerization-IN-8
CAS:<p>Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.</p>Fórmula:C21H24N4O4SCor e Forma:SolidPeso molecular:428.5Ack1 inhibitor 1
CAS:<p>Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].</p>Fórmula:C39H40F3N7O4Cor e Forma:SolidPeso molecular:727.77TTBK1/2-IN-3
CAS:<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.426ETB
CAS:<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Fórmula:C24H33NO6Peso molecular:431.52
