Sinalização Citoesquelética
Os inibidores de sinalização do citoesqueleto são compostos que interrompem as vias de sinalização que regulam o citoesqueleto, crucial para a forma celular, motilidade, divisão e transporte intracelular. Esses inibidores são usados para estudar a dinâmica das proteínas do citoesqueleto, como actina e tubulina, e seu papel em processos como migração celular, adesão e metástase do câncer. Os inibidores de sinalização do citoesqueleto são valiosos na pesquisa em biologia celular, câncer e neurobiologia. Na CymitQuimica, oferecemos uma ampla gama de inibidores de sinalização do citoesqueleto de alta qualidade para apoiar sua pesquisa nessas áreas.
Foram encontrados 1383 produtos de "Sinalização Citoesquelética"
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Cadherin Peptide, avian Acetate
<p>Cadherin Peptide, avian Acetate: a type-1 transmembrane protein sequence LRAHAVDVNG-NH2.</p>Fórmula:C46H79N17O15Pureza:97.69%Cor e Forma:SolidPeso molecular:1110.22Rebastinib
CAS:<p>DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC,</p>Fórmula:C30H28FN7O3Pureza:99.53% - 99.79%Cor e Forma:SolidPeso molecular:553.59FRAX1036
CAS:<p>FRAX-1036 is a effective and selective PAK1 inhibitor.</p>Fórmula:C28H32ClN7OPureza:97.66% - 98.67%Cor e Forma:SolidPeso molecular:518.05Tau protein (592-597), Human TFA
<p>Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein.</p>Fórmula:C36H63F3N10O11Pureza:>99.99%Cor e Forma:SolidPeso molecular:868.94Benproperine phosphate
CAS:<p>Benproperine phosphate (Pirexyl phosphate) is a cough suppressant.</p>Fórmula:C21H30NO5PPureza:99.84%Cor e Forma:PowderPeso molecular:407.44KW-2449
CAS:<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Fórmula:C20H20N4OPureza:98.43% - 99.69%Cor e Forma:SolidPeso molecular:332.4HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Fórmula:C24H28N6O2SPureza:99.91%Cor e Forma:SolidPeso molecular:464.584-Isopropoxybenzoic acid
CAS:<p>4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.</p>Fórmula:C10H12O3Pureza:99.88%Cor e Forma:White To Off-White PowderPeso molecular:180.2Valrubicin
CAS:<p>Valrubicin (AD-32) (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and has antitumor and anti-inflammatory activity.</p>Fórmula:C34H36F3NO13Pureza:98.63%Cor e Forma:SolidPeso molecular:723.64Orbofiban
CAS:<p>Orbofiban, an orally administered antagonist of the platelet GPIIb/IIIa receptor, effectively inhibits platelet aggregation.</p>Fórmula:C17H23N5O4Cor e Forma:SolidPeso molecular:361.4HSDVHK-NH2 acetate
<p>P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).</p>Fórmula:C32H52N12O11Pureza:99.5%Cor e Forma:SolidPeso molecular:780.39Rotigaptide TFA(355151-12-1 free base)
<p>Rotigaptide TFA is a Cx43 modulator & AAP that maintains gap junctions & cell communication under stress.</p>Fórmula:C30H40F3N7O11Pureza:99.21%Cor e Forma:SolidPeso molecular:731.67Parbendazole
CAS:<p>Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.</p>Fórmula:C13H17N3O2Pureza:99.60%Cor e Forma:Physical Description Crystals Or Fine White Powder (Ntp 1992)Peso molecular:247.29SB-743921 hydrochloride
CAS:<p>SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).</p>Fórmula:C31H34Cl2N2O3Pureza:95.58% - 99.70%Cor e Forma:SolidPeso molecular:553.52AG1024
CAS:<p>AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).</p>Fórmula:C14H13BrN2OPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:305.17KY-02327
CAS:<p>KY-02327: Stabilized KY-02061 analog, inhibits Dvl-CXXC5, activates Wnt/β-catenin, and promotes osteoblast differentiation.</p>Fórmula:C20H27N3O4Pureza:97.04%Cor e Forma:SolidPeso molecular:373.45Wiskostatin
CAS:<p>Wiskostatin selectively inhibits N-WASP, key in actin polymerization, linked to Wiskott-Aldrich Syndrome.</p>Fórmula:C17H18Br2N2OPureza:99.84% - 99.97%Cor e Forma:White SolidPeso molecular:426.15DTHIB
CAS:<p>DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.</p>Fórmula:C13H9ClFN3O3Pureza:98.86% - 99.29%Cor e Forma:SolidPeso molecular:309.68Cucurbitacin B
CAS:<p>Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.</p>Fórmula:C32H46O8Pureza:97.1% - 99.33%Cor e Forma:SolidPeso molecular:558.7Cilengitide
CAS:<p>Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.</p>Fórmula:C27H40N8O7Pureza:98% - 99.8%Cor e Forma:SolidPeso molecular:588.66Afuresertib
CAS:<p>Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic</p>Fórmula:C18H17Cl2FN4OSPureza:97.51% - 99.51%Cor e Forma:SolidPeso molecular:427.32Vevorisertib
CAS:<p>Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor with inhibitory effects on AKT1/AKT2/AKT3.</p>Fórmula:C35H38N8OPureza:98.88%Cor e Forma:SolidPeso molecular:586.73G-5555 hydrochloride
<p>G-5555 hydrochloride is a potent and selective inhibitor of PAK1 (Ki: 3.7 nM).</p>Fórmula:C25H26Cl2N6O3Cor e Forma:SolidPeso molecular:529.42SC79
CAS:<p>SC79 is an AKT agonist with specificity and blood-brain barrier permeability.</p>Fórmula:C17H17ClN2O5Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:364.78Darovasertib
CAS:<p>Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).</p>Fórmula:C22H23F3N8OPureza:98.72% - ≥95%Cor e Forma:SolidPeso molecular:472.47Nocodazole
CAS:<p>Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.</p>Fórmula:C14H11N3O3SPureza:98% - 99.91%Cor e Forma:Physical Description White Powder (Ntp 1992)Peso molecular:301.32Teprenone
CAS:<p>Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).</p>Fórmula:C23H38OPureza:99.1% - 99.96%Cor e Forma:SolidPeso molecular:330.55Go 6983
CAS:<p>Go 6983 is a PKC inhibitor with IC50 values of 7, 7, 6, 10, and 60 nM for PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, respectively. High-Quality, Low-Cost!</p>Fórmula:C26H26N4O3Pureza:98.41% - 99.85%Cor e Forma:SolidPeso molecular:442.51CEP-37440
CAS:<p>CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).</p>Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Cor e Forma:SolidPeso molecular:580.12Asciminib
CAS:<p>Asciminib (ABL001) (ABL001) is a potent and selective Bcr-Abl inhibitor (Kd: 0.5–0.8nM).</p>Fórmula:C20H18ClF2N5O3Pureza:98.82% - 99.70%Cor e Forma:SolidPeso molecular:449.84PF-562271 besylate
CAS:<p>PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.</p>Fórmula:C21H20F3N7O3S·C6H6O3SPureza:97.65% - 99.01%Cor e Forma:SolidPeso molecular:665.66Bisindolylmaleimide IV
CAS:<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Fórmula:C20H13N3O2Pureza:98.83%Cor e Forma:Dark Red SolidPeso molecular:327.34FRAX597
CAS:<p>FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).</p>Fórmula:C29H28ClN7OSPureza:97.34% - 99.85%Cor e Forma:SolidPeso molecular:558.1GPRP acetate (67869-62-9 free base)
CAS:<p>GPRP acetate (Pefabloc FG) is fibrinogen-related peptides, which inhibit the interaction of fibrinogen with the platelet membrane glycoprotein IIbIIIa complex.</p>Fórmula:C20H35N7O7Pureza:>99.99%Cor e Forma:SolidPeso molecular:485.53Olverembatinib dimesylate
CAS:<p>Olverembatinib dimesylate (GZD824 Dimesylate) is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I).</p>Fórmula:C29H27F3N6O·2CH4O3SPureza:97.66% - >99.99%Cor e Forma:SolidPeso molecular:724.77PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Fórmula:C26H34F3N5O7SPureza:99% - 99.46%Cor e Forma:SolidPeso molecular:617.63Danegaptide Hydrochloride
CAS:<p>Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.</p>Fórmula:C14H18ClN3O4Pureza:99.55%Cor e Forma:SolidPeso molecular:327.76BGG463
CAS:<p>BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.</p>Fórmula:C30H29F3N6O3Pureza:95.05% - >99.99%Cor e Forma:SolidPeso molecular:578.58Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Fórmula:C25H24N4O2Pureza:98.19% - 98.75%Cor e Forma:Orange SolidPeso molecular:412.48Bafetinib
CAS:<p>Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.</p>Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Cor e Forma:SolidPeso molecular:576.62Arg-Gly-Asp TFA (99896-85-2(free base))
<p>Arg-Gly-Asp TFA (RGD, 99896-85-2) is a tripeptide that promotes cell adhesion and integrin binding.</p>Fórmula:C14H23F3N6O8Pureza:99.2% - ≥98%Cor e Forma:SolidPeso molecular:460.36Miransertib
CAS:<p>Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.</p>Fórmula:C27H24N6Pureza:99.85% - ≥95%Cor e Forma:SolidPeso molecular:432.52DDO-5936
CAS:<p>DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.</p>Fórmula:C25H29N5O4SPureza:99.81%Cor e Forma:SolidPeso molecular:495.59Taurochenodeoxycholic Acid
CAS:<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Fórmula:C26H45NO6SPureza:99.53% - 99.86%Cor e Forma:SolidPeso molecular:499.7ATM-3507 trihydrochloride
CAS:<p>ATM-3507 trihydrochloride, a potent inhibitor of tropomyosin, demonstrates inhibition concentration (IC50) values ranging from 3.83 to 6.84 μM across various</p>Fórmula:C37H49Cl3FN5O2Cor e Forma:SolidPeso molecular:721.17p5 Ligand for Dnak and DnaJ acetate
<p>p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).</p>Fórmula:C46H85N15O13SPureza:96.33%Cor e Forma:SolidPeso molecular:1088.32GNF-5
CAS:<p>GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.</p>Fórmula:C20H17F3N4O3Pureza:98% - 99.94%Cor e Forma:SolidPeso molecular:418.37Mps1-IN-3 hydrochloride
<p>Mps1-IN-3 HCl: potent Mps1 inhibitor (IC50: 50 nM), hampers glioblastoma growth, enhances vincristine efficacy in vivo.</p>Fórmula:C26H32ClN7O4SCor e Forma:SolidPeso molecular:574.09
